Exercise attenuates neuropathic pain and neuroinflammation in an obese rat model exhibiting diabetes-related metabolic dysfunction and features of type 2 diabetes.
This study aimed to investigate the effects and mechanisms of exercise intervention on neuropathic pain in an obese rat model exhibiting diabetes-related metabolic dysfunction. Chronic constriction injury (CCI) was induced in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and the animals were rando…
Patient-Reported Continuity of GLP-1 Receptor Agonist Therapy.
Use of GLP-1 receptor agonists is associated with significant weight loss in many individuals. Discontinuation is associated with weight regain. Patients' experience with this is not well characterized. This study describes the patient experience of continuity of care. A cross-sectional electronic s…
Radiograph-based intervertebral sagittal translation-to-canal diameter ratio as a quantitative imaging marker for suspected lower cervical instability.
To compare radiographic differences between clinically suspected symptomatic lower cervical instability segments and asymptomatic normal segments and to evaluate the value of the radiograph-based intervertebral sagittal translation-to-canal diameter ratio (TCDR) as a quantitative imaging marker for…
[Preliminary construction and validation of an auxiliary diagnosis model for cervical instability based on multimodal deep learning].
To preliminarily construct and validate a diagnostic model for Cervical Spine Instability (CSI) based on multimodal deep learning, and to develop an open-access, web-based prototype platform tailored for clinical scenarios. Clinical data from 122 subjects were included, integrating three-position X-…
Unilateral biportal endoscopic cervical laminectomy with bilateral foraminotomy for cervical myeloradiculopathy: clinical and radiological outcomes at 1 year.
To evaluate the 1-year clinical and radiological outcomes of unilateral biportal endoscopic (UBE) cervical laminectomy with bilateral posterior cervical foraminotomy (PCF) in patients with cervical myeloradiculopathy. Thirty-three patients who underwent UBE cervical laminectomy with bilateral PCF be…
Manual and automated capture of analgesic-responsive facial pain behaviors of unrestrained mice in a trigeminal neuralgia model.
Trigeminal neuralgia (TN), a devastating neuropathic pain condition, profoundly affects human well-being. Despite an initial response to carbamazepine (CBZ), many patients become refractory to pharmacotherapy and subsequent invasive procedures. Although preclinical trigeminal neuropathic pain models…
Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling.
Trigeminal neuralgia (TN) is a disabling facial pain disorder, and current treatments remain insufficient for a substantial proportion of patients. Botulinum toxin type A (BoNT/A) has shown therapeutic benefit in TN, but its peripheral analgesic mechanisms remain incompletely understood. We aimed to…
Melatonin Ameliorates Neuropathic Pain in Mice by Regulating Pyroptosis Through Gut Microbiota-Mediated Linoleic Acid.
Neuropathic pain (NP) presents a significant challenge for patients with chronic diseases, characterized by spontaneous pain and hyperalgesia, with recent studies highlighting the involvement of the gut microbiota in its pathogenesis. Increasing evidence suggests that melatonin mitigates systemic in…