Exercise attenuates neuropathic pain and neuroinflammation in an obese rat model exhibiting diabetes-related metabolic dysfunction and features of type 2 diabetes.
This study aimed to investigate the effects and mechanisms of exercise intervention on neuropathic pain in an obese rat model exhibiting diabetes-related metabolic dysfunction. Chronic constriction injury (CCI) was induced in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and the animals were rando…
Unilateral biportal endoscopic cervical laminectomy with bilateral foraminotomy for cervical myeloradiculopathy: clinical and radiological outcomes at 1 year.
To evaluate the 1-year clinical and radiological outcomes of unilateral biportal endoscopic (UBE) cervical laminectomy with bilateral posterior cervical foraminotomy (PCF) in patients with cervical myeloradiculopathy. Thirty-three patients who underwent UBE cervical laminectomy with bilateral PCF be…
Manual and automated capture of analgesic-responsive facial pain behaviors of unrestrained mice in a trigeminal neuralgia model.
Trigeminal neuralgia (TN), a devastating neuropathic pain condition, profoundly affects human well-being. Despite an initial response to carbamazepine (CBZ), many patients become refractory to pharmacotherapy and subsequent invasive procedures. Although preclinical trigeminal neuropathic pain models…
Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling.
Trigeminal neuralgia (TN) is a disabling facial pain disorder, and current treatments remain insufficient for a substantial proportion of patients. Botulinum toxin type A (BoNT/A) has shown therapeutic benefit in TN, but its peripheral analgesic mechanisms remain incompletely understood. We aimed to…
Melatonin Ameliorates Neuropathic Pain in Mice by Regulating Pyroptosis Through Gut Microbiota-Mediated Linoleic Acid.
Neuropathic pain (NP) presents a significant challenge for patients with chronic diseases, characterized by spontaneous pain and hyperalgesia, with recent studies highlighting the involvement of the gut microbiota in its pathogenesis. Increasing evidence suggests that melatonin mitigates systemic in…
Ultrasound viscoelasticity and attenuation imaging for rheumatoid arthritis-associated muscle quality changes: a clinical transcriptomic study.
Rheumatoid arthritis (RA) is associated with loss of muscle quality and strength, but accessible quantitative tools for detecting these changes remain limited. We evaluated whether shear wave viscoelastic imaging (SWVI), acoustic attenuation imaging (AAI), and isokinetic strength testing could chara…
Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]-SMBT-1 Positron-Emission Tomography.
Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an altered astrocyte-neuron interplay. Evidence of astrocyte contributions to neuropathic pain are derived from both post-mortem immunohistochemical analyses and in vivo pharmacologica…
Radiograph-based intervertebral sagittal translation-to-canal diameter ratio as a quantitative imaging marker for suspected lower cervical instability.
To compare radiographic differences between clinically suspected symptomatic lower cervical instability segments and asymptomatic normal segments and to evaluate the value of the radiograph-based intervertebral sagittal translation-to-canal diameter ratio (TCDR) as a quantitative imaging marker for…