Non-suicidal self-injury and suicide attempts among individuals seeking assessment for Ehlers-Danlos Syndromes.
Individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) experience psychological distress and are at an increased risk for suicidal behaviors. The current study examined associations between factors uniquely relevant to this population and prior suicide…
Autonomic Assessment and Management in Sports-Related Concussion.
Autonomic dysfunction, or dysautonomia, is increasingly being recognized as a complication of concussion. While the symptoms can overlap with other postconcussion sequelae, it is important to distinguish the patient suffering from postconcussion dysautonomia in order to provide proper symptomatic ma…
Assessment of internal consistency reliability and concurrent validity of PROMIS® dyspnea characteristics v1.0, PROMIS® dyspnea functional limitations 10a, and PROMIS® global health v1.2 in a dysautonomia cohort.
Dyspnea, or shortness of breath, is frequently reported among individuals with autonomic nervous system dysfunction, or dysautonomia. Currently, there are no validated dyspnea-specific patient-reported outcome measures for this population. We conducted a patient-reported outcomes study to evaluate t…
Urinary Dysfunction in Myasthenic Syndromes: A Scoping Review of Clinical Features and Treatment-Related Associations.
Urinary dysfunction has been reported in association with myasthenic syndromes, including myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital myasthenic syndromes (CMS), but evidence regarding its prevalence, clinical impact, pathophysiology, and management remains limit…
Physiotherapy-integrated yoga and mindfulness plus home exercise versus home exercise alone for individuals with fibromyalgia syndrome (PhYoMind): study protocol of a randomised controlled clinical trial.
Fibromyalgia syndrome (FMS) is a chronic condition characterised by the presence of complex multiple symptoms, often accompanied by psychiatric comorbidities and sleep problems. The wide spectrum of symptoms and comorbid problems complicates treatment and management of the ensuing disability and sym…
Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.
Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated. Ivabradine, a sele…
Post-COVID paediatric dysautonomia: never the heart, always the brain-myth or maxim?
Paediatric dysautonomia has become increasingly recognised in children and adolescents, particularly in the post-COVID era. Affected patients commonly present with dizziness, palpitations, exercise intolerance, fatigue, and syncope, although reported prevalence varies widely because of evolving defi…
High-grade left atrial intimal sarcoma mimicking myxoma: The diagnostic and therapeutic relevance of tumor topography.
Primary cardiac tumors are rare; among them, sarcomas represent an aggressive minority with complex diagnosis and poor prognosis. We report the case of a 45-year-old woman with a history of dysautonomia who presented with progressive dyspnea (New York Heart Association class II-III) and exertional a…