Inducible Laryngeal Obstruction in Hypermobile Patients.
To determine whether patients with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD) and inducible laryngeal obstruction (ILO) have more voice, cough, swallowing, GI issues, and MC activation than patients without ILO. This retrospective study of 2162 patients meeti…
Fracture Prevalence Among Those With Hypermobility Spectrum Disorder/Hypermobile Ehlers-Danlos Syndrome.
Previous series have questioned bone fragility in those with hypermobility spectrum disorders (HSD) or hypermobile Ehlers-Danlos syndrome (hEDS). These conclusions have been extrapolated to infants and children often in the setting of suspected child abuse. Few studies address this in non-ambulatory…
Pediatric Abdominal Vascular Compression Syndromes: Clinical Presentation, Comorbidities, and Outcomes Following Surgical Correction.
The goal of this case series was to characterize the clinical presentation, comorbidities, and postoperative outcomes of pediatric patients who underwent surgical repair for Median Arcuate Ligament Syndrome (MALS) and/or Nutcracker Syndrome (NCS). We conducted a retrospective chart review of 17 pedi…
The Intersection of Hypermobile Ehlers-Danlos Syndrome and Thoracic Outlet Syndrome.
Hypermobile Ehlers-Danlos syndrome (hEDS) is a rare disorder resulting in joint hypermobility. Thoracic outlet syndrome (TOS) is an uncommon compressive disorder affecting neurovascular structures of the upper limb. The coincidence of these syndromes may affect the prognosis of interventions for TOS…
The WNT/β-catenin Pathway and Matrix Metalloproteinase-9 in hypermobile Ehlers-Danlos Syndrome and Autism Spectrum Disorder: A Possible Connection.
Hypermobile Ehlers-Danlos Syndrome (hEDS), a connective tissue disorder also known as Ehlers-Danlos Syndrome Type III or Ehlers-Danlos Syndrome Hypermobility Type, and Autism Spectrum Disorder (ASD), a neurodevelopmental disorder, present notable symptom overlap and higher than expected level of com…
Transcutaneous auricular vagus nerve stimulation improves dysautonomia in patients with hypermobile Ehlers-Danlos syndrome.
Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes substantially to multisystem symptoms and reduced quality of life. Neuroimmune dysregulation and chronic low-grade inflammation are increasingly recognized as key mechanisms underlyi…
Hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome: patient experiences, disability and implications for rehabilitation.
The diagnosis and management of hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome (HSD/hEDS) are a healthcare challenge because of the wide array of symptoms, lack of diagnostic biomarkers, and evolving management guidelines. This study aimed to describe patient experiences, di…
DNA methylation: unifying framework for complex chronic conditions.
Complex chronic conditions represent a growing health burden that is poorly understood and inadequately managed within current health systems. This review focuses on the potential of epigenetic DNA methylation to provide a pathway for better understanding of four closely related conditions: myalgic…