Mast cell activation syndrome: Global perspectives from a World Allergy Organization survey on knowledge, diagnosis, and access to care.
Mast Cell Activation Syndrome (MCAS) has emerged as a highly debated and increasingly recognized condition in allergy and clinical immunology. Despite established AIM/ECNM consensus criteria, major uncertainties persist regarding its diagnosis, implementation in real-world practice, and equitable ac…
Exploring the photophysics of dibenzo[g,p]chrysene and tetraphenylethene in solution by static and dynamical quantum mechanical calculations.
Multichromophore assemblies (MCAs) of π-conjugated molecules exhibit complex photophysical behavior arising from the interplay between intra- and intermolecular interactions and environmental effects. In this work, we present a comprehensive computational study of two representative systems, d…
Non-immunoglobulin E-mediated mechanisms of anaphylaxis.
Anaphylaxis attributable to non-immunoglobulin E (IgE)-mediated mechanisms represents an increasingly recognized and clinically challenging subset of severe hypersensitivity reactions. This review synthesizes recent advances in the understanding of IgE-independent pathways, with emphasis on literatu…
Renal Denervation for Uncontrolled Hypertension in a Patient With Mast Cell Activation Syndrome.
Renal denervation (RDN) is a treatment option for resistant hypertension. We present a 64-year-old woman with medication intolerance secondary to mast cell activation syndrome who presented with uncontrolled hypertension and underwent bilateral RDN. Her systolic and diastolic recordings measured usi…
Parallelized bright-field and fluorescence imaging platform for organoids.
Organoid viability, maturation, and growth are commonly assayed through bright-field and fluorescence microscopy using a single-objective lens. However, standard imaging systems pose significant limitations for high-throughput applications, particularly in large-scale experiments requiring simultane…
Collagen digestion mimics strain-induced softening in cerebral arteries.
Cerebral blood vessels are commonly injured in both trauma and surgical procedures. Constitutive damage models that predict vessel response to injury are critical to improved prevention and treatment. Prior research shows that stretch alters vessel mechanical properties but that denaturation of the…
Chitosan nanocomposite scaffolds enable controlled 4-methoxycinnamic acid release to enhance bone regeneration.
Chitosan (CS)-based scaffolds are promising platforms for bone tissue engineering due to their biocompatibility and tunable drug delivery properties. Here, we report the development of 3D-printed polylactic acid scaffolds coated with polydopamine and loaded with CS nanoparticles encapsulating 4-meth…
EXPRESS: Hemodynamic Analysis of Lenticulostriate Artery Dilation in MCA Atherosclerotic Stenosis.
To investigate the perfusion changes associated with lenticulostriate artery (LSA) dilation in patients with middle cerebral artery (MCA) atherosclerosis utilizing 7.0T MRI and CT perfusion imaging (CTP). Forty-eight symptomatic atherosclerotic MCA plaques were analyzed. All patients underwent 7.0T…