Objective Evaluation of the Effects of Ramadan Fasting on Nasal Respiratory Function.
Previous studies are insufficient concerning the impact of fasting on nasal functions. This study aimed to investigate the effects of Ramadan fasting (RF) on nasal respiratory function (NRF) utilizing objective assessments, based on the hypothesis that RF leads to functional improvement in healthy s…
Characteristics and outcomes of patients with pediatric-onset non-mastocytosis mast cell activation disorders: A CEREMAST study.
Mast cell (MC) activation (MCA) disorders (MCAD) include diseases in which MCs excessively release mediators leading to recurrent manifestations of MCA. MCAD encompasses MCA syndrome (MCAS) which is defined by (i) documented systemic symptoms of MCA, (ii) a 20% increase in serum tryptase level from…
Color Doppler Ultrasound Parameters of Fetal Umbilical Artery and Middle Cerebral Artery Assist in Diagnosing Hypertensive Disorder of Pregnancy and Evaluating the Severity in Women of Advanced Maternal Age.
This study investigated the clinical significance of fetal umbilical artery (UA) and middle cerebral artery (MCA) Color Doppler parameters in the prenatal diagnosis of hypertensive disorder complicating pregnancy (HDCP) in pregnant women of advanced maternal age (AMA). AMA women with HDCP (245 gesta…
Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder that is often diagnosed after diagnostic delays due to reliance on heightened clinical suspicion. Hypermobility spectrum disorders (HSD) bridge the gap between asymptomatic joint hypermobility and hEDS. Due to overlapping feat…
Human aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges. We present the mCAS (multicentric Chinese aging standardized cohort) developed from 2,019 Chinese individuals aged 18-91 years. Integrating hig…
Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study.
Folic acid (FA) is essential for fetal development, while the benefits and optimal dose in pregnant women with epilepsy (PWWE) remain unclear. This study explores effects of FA supplementation, dose, and initiation time on offspring outcomes in PWWE. This multi-center cohort recruited PWWE from 58 h…
Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) are two types of clonal hematopoiesis (CH) associated with hematological parameters and malignancy risk. Here we show, in genomic data from 546,090 biobank participants, that co-occurring CH (≥2 C…
Patterns and drivers of 43,617 mosaic chromosomal alterations in blood.
Clonal expansions of hematopoietic cells carrying mosaic chromosomal alterations (mCAs) are commonly detectable in elderly individuals. Here we studied 43,617 autosomal mCAs ascertained in 484,081 UK Biobank participants using new, high-resolution computational methods to analyze blood-derived, whol…