Mast cell activation disorders: mechanisms, comorbidities and look alike.
Mast Cells (MCs) are unique tissue immune cells found perivascularly close to nerves at interfaces with the external environment. Upon detection of danger signals, MCs act as master responders aiming to restore homeostasis. If MCs are not optimally regulated, they can contribute to the pathogenesis…
A Real-World Cross-Sectional Study on Suspected Mast Cell Activation Syndrome: Multiple Heterogeneous Symptoms Identified.
A variety of clinical signs and symptoms have been described in patients suspected of having mast cell activation syndrome (MCAS), however, symptom patterns and linked organ systems were not yet described. This cross-sectional online survey included adults with physician-diagnosed self-assessed or s…
A Follow-Up Study of the Supraaortic and Intracranial Vessels, Cerebrovascular Reactivity, Brain Vascular Lesions and Atrophy in Patients with Rheumatoid Arthritis.
Background/Objectives: Rheumatoid arthritis (RA) has been associated with accelerated atherosclerosis and cerebrovascular alterations. Our 2017 study compared 60 RA patients to healthy controls, assessing vascular, neurological, and cognitive parameters. The present study is a follow-up of these RA…
Fetal Arterial and Venous Doppler Parameters Based on Amniotic Fluid Volume and Glycemic Status.
In this study, it was aimed to evaluate fetal arterial and venous Doppler parameters and to assess their association with adverse obstetric outcomes by focusing on the amniotic fluid volume and glycemic status of pregnant women. A prospective study was conducted at a tertiary care center from August…
Assessment of cerebrovascular reactivity in middle cerebral artery stenosis using non-hypercapnic resting-state fMRI: a potential biomarker for hemodynamic alterations.
Cerebrovascular reactivity(CVR), a key indicator of cerebrovascular reserve, is crucial for evaluating cerebrovascular pathophysiology. This study employed resting-state MRI (rs-MRI) to assess CVR alteration in patients with unilateral middle cerebral artery stenosis or occlusion (MCA-S) under non-h…
Abluminal plasma induces vasoconstriction meditated by serotonin and counterbalanced by endothelial nitric oxide synthase in healthy and malarial mouse arteries.
Background & Purpose: Experimental cerebral malaria (ECM) is associated with abnormalities in cerebral perfusion, yet the mechanisms underlying vascular dysfunction remain incompletely defined. Experimental Approach: Ex vivo pressure myography of middle cerebral arteries (MCAs) was used to assess in…
Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.
Since establishment in 2020 of the global consensus-2 diagnostic criteria for mast cell activation syndrome (MCAS), recognition of this prevalent disease, existing alongside rare cutaneous or systemic mastocytosis, has grown significantly. Despite this progress, some have continued using more restri…
Mast cell score associates with wide-spread mast cell symptoms and comorbidities in patients with hEDS and HSD.
Wide-spread mast cell (MC)-associated symptoms and MC activation syndrome (MCAS) are often reported in patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD). The goal of this study was to develop a novel MC score based on 11 self-reported MC-related condi…