Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years.
Since establishment in 2020 of the global consensus-2 diagnostic criteria for mast cell activation syndrome (MCAS), recognition of this prevalent disease, existing alongside rare cutaneous or systemic mastocytosis, has grown significantly. Despite this progress, some have continued using more restri…
Human aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges. We present the mCAS (multicentric Chinese aging standardized cohort) developed from 2,019 Chinese individuals aged 18-91 years. Integrating hig…
Folic acid supplementation and prevention of adverse offspring outcomes among women with epilepsy: An observational study.
Folic acid (FA) is essential for fetal development, while the benefits and optimal dose in pregnant women with epilepsy (PWWE) remain unclear. This study explores effects of FA supplementation, dose, and initiation time on offspring outcomes in PWWE. This multi-center cohort recruited PWWE from 58 h…
Characteristics and outcomes of patients with pediatric-onset non-mastocytosis mast cell activation disorders: A CEREMAST study.
Mast cell (MC) activation (MCA) disorders (MCAD) include diseases in which MCs excessively release mediators leading to recurrent manifestations of MCA. MCAD encompasses MCA syndrome (MCAS) which is defined by (i) documented systemic symptoms of MCA, (ii) a 20% increase in serum tryptase level from…
[Mast Cells Activation Syndrome: Clinical Spectrum, Diagnosis and Treatment].
Mast cells are key components of the innate immune system and play a central role in the "classical" allergic response. These cells are predominantly located in the skin, mucosal tissues, respiratory tract, and gastrointestinal system. Their cytoplasmic granules contain a variety of potent mediators…
Objective Evaluation of the Effects of Ramadan Fasting on Nasal Respiratory Function.
Previous studies are insufficient concerning the impact of fasting on nasal functions. This study aimed to investigate the effects of Ramadan fasting (RF) on nasal respiratory function (NRF) utilizing objective assessments, based on the hypothesis that RF leads to functional improvement in healthy s…
Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) are two types of clonal hematopoiesis (CH) associated with hematological parameters and malignancy risk. Here we show, in genomic data from 546,090 biobank participants, that co-occurring CH (≥2 C…
Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder that is often diagnosed after diagnostic delays due to reliance on heightened clinical suspicion. Hypermobility spectrum disorders (HSD) bridge the gap between asymptomatic joint hypermobility and hEDS. Due to overlapping feat…