Sleep restriction induces histoarchitectural and cellular remodeling in the rat distal colon: a peripheral consequence of circadian disruption.
Sleep restriction disrupts circadian organization and represents a behavioral condition with systemic consequences that extend beyond the central nervous system. In this study, we evaluated structural and cellular changes in the distal colon of rats exposed to sustained sleep restriction. Sixteen ma…
Statement of Retraction: Aedes albopictus salivary proteins adenosine deaminase and 34k2 interact with human mast cell specific proteases tryptase and chymase.
Systemic inflammation increases mast cell numbers in coronary arteries in patients who died from myocardial infarction.
Systemic inflammation caused by infection peaks the risk of acute myocardial infarction (AMI), presumably by affecting atherosclerotic plaque (AP) stability. In this study, APs were examined in AMI patients with acute infection (AI). Four groups of AMI patients with or without AI were compared to de…
Association of a Han Chinese urticaria-derived polygenic risk score with chronic spontaneous urticaria susceptibility and advanced systemic treatment use.
Chronic spontaneous urticaria (CSU) is a heterogeneous mast cell-driven disease with variable treatment needs, but the clinical relevance of Han Chinese urticaria-derived polygenic risk scores (PRSs) remains unclear. To evaluate the associations between Han Chinese urticaria-derived PRSs, CSU suscep…
Single-cell RNA sequencing uncovers an immunosuppressive program in PDAC mast cells: tumour-driven activation, proliferation, and association with Treg recruitment.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly immunosuppressive tumour microenvironment (TME), which contributes to its resistance to immunotherapy. Although mast cells (MCs) have been implicated in PDAC progression, their functional heterogeneity and candidate signaling model…
Serum baseline tryptase levels across chronic kidney disease stages: A retrospective report.
Chronic kidney disease (CKD) has been associated with elevated serum baseline tryptase (sBT) levels, which may exceed the standard reference value of less than 11.5 ng/mL as kidney function declines. This study aimed to characterize sBT levels across different CKD stages in a United States-based coh…
Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition.
Paulownia tomentosa (PT) exhibits diverse biological activities, including anti‑inflammatory and antioxidant effects; however, its potential effects on atopic dermatitis (AD) are unclear. The present study examined the effects of PT flower absolute (PTFAb) on AD‑related responses, part…
Comparative Immunohistochemical Study of Canine Mammary Tumours: Introducing of Triple-Negative Profile (ER-/PR-/HER2-) in Benign Mammary Tumours of Animal Model.
Mammary tumours are the most common neoplasm in female dogs. Canine mammary tumours (CMTs) are appropriate models for human studies. The present study aimed to diagnose CMTs pathologically and compare different tumour types by immunohistochemistry (IHC). Histological features of various tumours were…