Comprehensive evaluation of tick infestation dynamics and host response in Kankrej and Holstein Friesian crossbred cattle.
Ticks and tick-borne diseases present significant challenges to cattle production. In this context, natural host resistance to ticks emerges as a promising and sustainable alternative. The present study aimed to clarify the phenotypic, immunological, and genetic factors contributing to the superior…
Revisiting pharmacological actions of disodium cromoglycate in light of GPR35: New therapeutic contexts for classical drugs.
Mast cell stabilizers such as disodium cromoglycate have been used for decades as prophylactic anti-allergic agents, yet their molecular targets remained unknown, and their intracellular mechanisms were long debated. Identification of GPR35 as a receptor engaged by multiple mast cell stabilizers pro…
Activation of GABABR alleviates colitis by reprogramming macrophage polarization via the IRAK-M/NLRP3/NF-κB pathway.
Although the metabotropic GABA type B receptor (GABABR) has emerged as an immune modulator, its specific role in regulating the dysregulated macrophage polarization that drives inflammatory bowel disease (IBD) pathogenesis remains undefined. Utilizing a dextran sulfate sodium-induced colitis model a…
Mast cell activation disorders: mechanisms, comorbidities and look alike.
Mast Cells (MCs) are unique tissue immune cells found perivascularly close to nerves at interfaces with the external environment. Upon detection of danger signals, MCs act as master responders aiming to restore homeostasis. If MCs are not optimally regulated, they can contribute to the pathogenesis…
Barrier restoration as a therapeutic strategy for disorders of gut-brain interaction.
Disorders of gut-brain interaction, such as irritable bowel syndrome and functional dyspepsia, are increasingly linked to defects in gut barrier function. Mucosal disruption, encompassing alterations in the epithelial and mucus layers, leads to enhanced intestinal permeability, microbial translocati…
Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.
Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-IBD affecting the colon (PSC-ulcerative colitis or PSC-UC) resembles clinical UC, but is characterised by less severe disease flares, right-colo…
Mast cell-derived IL-13 as a driver of Crohn disease-associated intestinal fibrosis.
Crohn disease is a chronic, immune-mediated disease that can lead to intestinal fibrosis, strictures, and bowel obstruction. The Src homology 2 domain-containing inositol polyphosphate 5'-phosphatase-deficient (SHIP-/-) mouse develops spontaneous Crohn disease-like ileal inflammation and fibrosis. F…