Comprehensive evaluation of tick infestation dynamics and host response in Kankrej and Holstein Friesian crossbred cattle.
Ticks and tick-borne diseases present significant challenges to cattle production. In this context, natural host resistance to ticks emerges as a promising and sustainable alternative. The present study aimed to clarify the phenotypic, immunological, and genetic factors contributing to the superior…
Hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome: patient experiences, disability and implications for rehabilitation.
The diagnosis and management of hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome (HSD/hEDS) are a healthcare challenge because of the wide array of symptoms, lack of diagnostic biomarkers, and evolving management guidelines. This study aimed to describe patient experiences, di…
Pathophysiological Drivers of Mast Cell Activation Syndrome and Implications for Treatment.
Mast Cell Activation Syndrome (MCAS) is an underrecognized multisystem disorder causing nonspecific and diverse symptoms, making it difficult for clinicians to diagnose and treat. This comprehensive review provides an overview of the signs and symptoms of MCAS while investigating the known pathophys…
Comparison of processing approaches for single-cell analysis of esophageal biopsy samples.
Eosinophilic esophagitis is an eosinophil-rich type 2 inflammatory disease with increasing global prevalence. Multicenter randomized trials are critical, but use of certain cutting-edge techniques, such as single-cell sequencing, can be challenging owing to a requisite need for immediate tissue proc…
Beyond Histamine: Mast Cell-Neuron Communication in Chronic Pruritic and Pain Disorders.
Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell-mediated itch, accumulating evidence indicates that non-histaminergic…
Development of cold urticaria after cryotherapy during laser epilation for pilonidal disease: a case report.
Laser epilation is utilized to reduce pilonidal disease (PD) recurrence and commonly employs cryotherapy for analgesia. Cryotherapy can lead to cold urticaria, particularly in patients with unrecognized cold sensitivity. We report two cases of cold urticaria that developed during laser epilation for…
2'-FL's Depiction of the Human Physiological Function Landscape.
2'-fucosyllactose (2'-FL) is a major fucosylated human milk oligosaccharide characterized by a terminal α1,2-linked fucose residue, which supports its interactions with gut microbes, host glycan-recognition systems, and pathogen-binding sites. This review proposes that 2'-FL acts mainly throug…
The genesis of cutaneous neurogenic inflammation is a multi-step process requiring dendritic cell aggregation.
Cutaneous inflammation involving neuroimmune interactions can be initiated by both neurons and immune cells, making it complicated to parse the mechanisms of neurogenic inflammation. Optogenetic activation of Trpv1-expressing nociceptors drives type-17 inflammation in the absence of other inflammato…