Mixed Connective Tissue Disease

Performance of Large Language Models in Differentiating Systemic Lupus Erythematosus From Mimicking Conditions Using the 2019 EULAR/ACR Criteria: A Comparative Analysis.

Systemic Lupus Erythematosus (SLE) presents a significant diagnostic challenge for clinicians due to its diverse clinical manifestations and overlap with other autoimmune conditions. Large Language Models (LLMs) are currently regarded as having the potential to assist clinicians in expediting decisi…

Dermatomyositis predominates among checkpoint inhibitor-associated inflammatory myositis phenotypes: a pharmacovigilance disproportionality analysis identifies a class-wide signal.

ICI-induced inflammatory myositis (IIM) is a recognized irAE with significant morbidity and potential for life-threatening overlap syndromes. Whether polymyositis (PM) and dermatomyositis (DM) carry differential pharmacovigilance signals across ICI drug classes has not been systematically examined.…

Real-World Distributions and Concordance of C-Reactive Protein and Erythrocyte Sedimentation Rate Across Rheumatic Diseases.

Objective: The objective of this study was to characterize real-world distributions of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) across major rheumatic diagnoses and to quantify concordance/discordance patterns and combined CRP-ESR inflammatory phenotypes. Methods: We retrosp…

Clinicopathologic Characterization of Muscle Biopsy Findings in Overlap Myositis: A Single Tertiary Care Center Experience.

This study aims to describe the muscle biopsy features of overlap myositis (OM) and compare them with other inflammatory myopathies. We analyzed clinical, serological findings, and histopathological patterns in muscle biopsies to understand the features of OM. Muscle biopsies submitted from patients…

Environmental and occupational factors in the aetiopathogenesis of systemic sclerosis: insights from a large multinational patient survey.

Systemic sclerosis (SSc) is a rare and heterogeneous disease. SSc pathobiology is complex and it occurs in a genetically susceptible host. Our aim was to describe potential environmental and occupational exposures relevant to SSc. An online survey was developed in English to collect detailed informa…

Severe Peripheral Arterial Ischemia Leading to Digital Gangrene in Mixed Connective Tissue Disease: A Case Report.

Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disorder characterized by overlapping clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, in association with anti-U1 ribonucleoprotein (anti-U1-RNP) antibodies. Although vascular manifestations…

Late Mitral Valve Stenosis After Transcatheter Edge-to-Edge Repair Due to Mixed Connective Tissue Disease.

Overlap Syndrome of Ankylosing Spondylitis and Mixed Connective Tissue Disease in a Male Patient.

Spondyloarthritis (SPA) is a chronic systemic inflammatory disease predominantly affecting young men, with axial and peripheral involvement and extra-articular manifestations, including uveitis, inflammatory bowel disease, and psoriasis. Mixed connective tissue disease (MCTD) is a rare, heterogeneou…