Mixed Connective Tissue Disease

A case of suspected hydroxychloroquine-induced cardiomyopathy: From therapy to toxicity.

Hydroxychloroquine (HCQ) is a cornerstone treatment for rheumatologic diseases. While it is generally well tolerated, chronic use has rarely been associated with cardiotoxicity. It is believed to occur due to the accumulation of HCQ in lysosomes, which impairs enzyme activity and eventually leads to…

Immune checkpoint inhibitor-induced myocarditis with myositis and/or myasthenia gravis overlap syndrome: A case series.

Immune checkpoint inhibitors (ICIs) can lead to immune-related adverse events, including myocarditis with myositis and/or myasthenia gravis overlap syndrome (IM3OS). This syndrome poses notable management challenges and has high mortality rates. Due to limited data, its clinical features and optimal…

Anti-c-Mpl antibody-positive acquired amegakaryocytic thrombocytopenia with immune thrombocytopenia-like features in mixed connective tissue disease.

Acquired amegakaryocytic thrombocytopenia is a rare cause of severe thrombocytopenia characterized by a marked reduction in bone marrow megakaryocytes and may be difficult to distinguish clinically from immune thrombocytopenia. Acquired amegakaryocytic thrombocytopenia has been reported in various a…

[Myositis induced by immune checkpoint inhibitor therapy].

Immune-mediated myositis can be a severe side effect of cancer treatment involving immune checkpoint inhibitors (ICI). As a distinct type of rheumatic immune-related adverse events (irAE), it presents challenges in terms of diagnosis and patient management. The high mortality and the poten…

Anti-U1-RNP-Positive Inflammatory Myopathy Presenting With Dysphagia: A Case Report.

High-titer anti-U1-RNP antibodies may present with myopathy without fulfilling MCTD criteria. We report a 38-year-old woman with proximal weakness, elevated muscle enzymes, anti-U1-RNP positivity, and inflammatory myopathy on EMG/MRI, but lacking classic overlap features. Early recognition enabled i…

Oral Minoxidil for Alopecia in Systemic Sclerosis, Dermatomyositis, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease: A Retrospective Chart Review on Cardiovascular Risk.

Discordant Internal and External Validation Performance in a Multicenter Nomogram for Overlap Syndrome in Systemic Lupus Erythematosus.

Interstitial lung disease in mixed connective tissue disease: Insights from an electronic health record-based retrospective cohort study.

Pulmonary complications, including interstitial lung disease (ILD), are common and contribute to morbidity and mortality in mixed connective tissue disease (MCTD). However, risk factors for ILD in MCTD are poorly understood, which can hinder early detection of this fatal complication. The purpose of…