Mixed Connective Tissue Disease

Severe Cardiac Involvement in a Young Woman with Mixed Connective Tissue Disease Complicated by Macrophage Activation Syndrome.

Reports of severe mixed connective tissue disease (MCTD) or macrophage activation syndrome (MAS)-associated cardiac involvement are limited. A 37-year-old woman with MCTD was transferred to a local hospital with fever and headache. She was diagnosed with meningitis and treated with glucocorticoid (G…

Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.

Nailfold videocapillaroscopy (NVC) provides direct, non-invasive access to the peripheral microcirculation and has become a central tool in adult rheumatology. Its primary clinical value lies in the evaluation of patients presenting with signs of Raynaud phenomenon (RP) and scleroderma-spectrum diso…

Phosphaturic Mesenchymal Tumour of the Soft Tissue in the Finger Presenting without Tumour-Induced Osteomalacia: A Case Report.

Phosphaturic mesenchymal tumour (PMT) is a rare neoplasm that can occur with or without tumour-induced osteomalacia (TIO). While PMTs commonly arise in the lower extremities or head and neck, digital involvement is rare. A 70-year-old man presented with a 12-year history of an enlarging subcutaneous…

Polyarteritis nodosa and antiphospholipid syndrome: a systematic review of a rare and challenging overlap between vasculitis and thrombotic vasculopathy.

The coexistence of polyarteritis nodosa (PAN) and antiphospholipid syndrome (APS) is rarely reported and remains poorly characterized. Both conditions may involve vascular injury, but through distinct mechanisms-necrotizing inflammation in PAN and thrombotic vasculopathy in APS. Their overlap may re…

Impact of Inflammatory Disorders on Outcomes in Acute Heart Failure: A Nationwide Analysis.

Introduction Acute heart failure (AHF) is characterized by rapid symptom deterioration and high mortality. This study evaluates how eight inflammatory disorders, driven by systemic inflammation, immune dysfunction, and antirheumatic cardiotoxicity, impact in-hospital mortality, complications, and le…

The Convergence of Fibrosis and Granulomatous Inflammation: A Case Series on the Diagnostic and Therapeutic Challenges of Systemic Sclerosis and Sarcoidosis Overlap Syndrome.

The coexistence of systemic sclerosis and sarcoidosis is very rare. Both are systemic autoimmune diseases with lung involvement but different pathogenesis. In contrast to findings of mid- to upper-lobe interstitial lung disease (ILD) that may occur with hilar lymphadenopathy in sarcoidosis, the most…

Raynaud's phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy.

Raynaud's phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed co…

Successful rechallenge of immune checkpoint inhibitor after immune-related myocarditis, myositis, myasthenia gravis overlap syndrome (IM3OS).