Triple M Overlap Syndrome After Immune Checkpoint Inhibitors: A Case Series of a High-Mortality Phenotype.
Immune checkpoint inhibitor-associated Triple M overlap syndrome (TMOS), defined by concurrent myocarditis, myositis, and myasthenia gravis, is a rare but life-threatening immune-related adverse event. We report a single-center case series of 8 consecutive patients who developed TMOS during immune c…
Comparative Study of Sporadic and Immune Checkpoint Inhibitor-Related Forms of Myasthenia Gravis-Myositis Overlap Syndrome.
Myasthenia gravis-inflammatory myopathy (MG-IM) overlap syndrome can occur as an immune-related adverse event (irAE) after immune checkpoint inhibitor (ICI) therapy. Before the advent of ICIs, a sporadic form of MG-IM (s-MG-IM), often thymoma-associated, was already described. This study compared cl…
Triple M overlap syndrome in the intensive care unit: differential diagnosis and management.
Immune checkpoint inhibitors (ICIs) are increasingly used as first-line therapy for various malignancies and are associated with a growing spectrum of immune-related adverse events. While many toxicities are managed in the outpatient setting, a clinically significant subset progresses to life-threat…
Dermatomyositis predominates among checkpoint inhibitor-associated inflammatory myositis phenotypes: a pharmacovigilance disproportionality analysis identifies a class-wide signal.
ICI-induced inflammatory myositis (IIM) is a recognized irAE with significant morbidity and potential for life-threatening overlap syndromes. Whether polymyositis (PM) and dermatomyositis (DM) carry differential pharmacovigilance signals across ICI drug classes has not been systematically examined.…
Performance of Large Language Models in Differentiating Systemic Lupus Erythematosus From Mimicking Conditions Using the 2019 EULAR/ACR Criteria: A Comparative Analysis.
Systemic Lupus Erythematosus (SLE) presents a significant diagnostic challenge for clinicians due to its diverse clinical manifestations and overlap with other autoimmune conditions. Large Language Models (LLMs) are currently regarded as having the potential to assist clinicians in expediting decisi…
Real-World Distributions and Concordance of C-Reactive Protein and Erythrocyte Sedimentation Rate Across Rheumatic Diseases.
Objective: The objective of this study was to characterize real-world distributions of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) across major rheumatic diagnoses and to quantify concordance/discordance patterns and combined CRP-ESR inflammatory phenotypes. Methods: We retrosp…
Environmental and occupational factors in the aetiopathogenesis of systemic sclerosis: insights from a large multinational patient survey.
Systemic sclerosis (SSc) is a rare and heterogeneous disease. SSc pathobiology is complex and it occurs in a genetically susceptible host. Our aim was to describe potential environmental and occupational exposures relevant to SSc. An online survey was developed in English to collect detailed informa…
Clinicopathologic Characterization of Muscle Biopsy Findings in Overlap Myositis: A Single Tertiary Care Center Experience.
This study aims to describe the muscle biopsy features of overlap myositis (OM) and compare them with other inflammatory myopathies. We analyzed clinical, serological findings, and histopathological patterns in muscle biopsies to understand the features of OM. Muscle biopsies submitted from patients…