Clinical predictors for bloodstream infection in systemic lupus erythematosus.
This study aimed to investigate the distribution of pathogenic bacteria and identify clinical predictors associated with bloodstream infection (BSI) in patients with systemic lupus erythematosus (SLE). The experimental group included 43 SLE patients with BSI (SLE-BSI), who were diagnosed and treated…
Burden among participants with central disorders of hypersomnolence in six European countries.
Narcolepsy types 1 and 2 (NT1/NT2) and idiopathic hypersomnia (IH) are central disorders of hypersomnolence (CDHs) that significantly impact patients' quality of life (QoL). We investigated the recent medication use, comorbidities, and clinical burden among participants with CDHs from six European c…
Comparison of heart rate responses at respiratory event termination in children referred for assessment of hypersomnolence.
Adult studies have linked disorders of hypersomnolence to impaired heart rate (HR) control. We examined HR changes during obstructive and central respiratory events in children referred for assessment of hypersomnolence compared to controls. 20 children diagnosed with narcolepsy, 7 with idiopathic h…
Prevalence and incidence of fibromyalgia and associated severity in the United States using MarketScan.
Fibromyalgia is characterized by a range of symptoms, the most prominent being chronic widespread pain, fatigue, and unrefreshing sleep. This study estimated the diagnosed annual prevalence, incidence, and severity of fibromyalgia among adults (≥18 years) and the pediatric population (<18 yea…
Risk of depressive symptom burden across central disorders of hypersomnolence: A nationwide multicenter study.
Central disorders of hypersomnolence (CDH) significantly impair quality of life, yet the burden of depressive symptoms across their subtypes remains poorly understood. We aimed to examine the clinical profiles and risk factors for depression burden among patients with narcolepsy type 1 (NT1), narcol…
RNA in situ hybridization for ISG15 and IFI6 highlights IFN-I activity in discoid lupus erythematosus.
IFN-I signaling is a hallmark of discoid lupus erythematosus (DLE), but routine tissue-based assays to detect this pathway are limited. Re-analysis of public transcriptomic data identified ISG15 and IFI6 as candidate IFN markers, ranking among the top differentially expressed genes in DLE datasets.…
Effects of Transcutaneous Electrical Nerve Stimulation, Electrical Muscle Stimulation, Exercise and Heat on Back Pain-A Randomized Controlled Clinical Exploratory Trial.
This randomized controlled study compared different forms of therapy for chronic back pain. Seventy-nine patients with chronic back pain with a duration of symptoms of more than 6 months were included in the study and randomly assigned to one of four therapy groups (a) sports therapy with a f…
Refractory severe type B insulin resistance treated with daratumumab.
Type B insulin resistance syndrome (TBIRS) is a rare autoimmune condition characterized by insulin receptor autoantibodies, often in association with systemic lupus erythematosus (SLE). It can cause extreme insulin resistance, with fewer than 200 cases described worldwide. A 24-year-old man with no…