Embolization of spontaneous retroperitoneal bleeding fed by aneurysmal arc of Bühler: Case report and technical considerations.
The arc of Bühler (AOB) is a rare embryonic anastomosis between the celiac artery and the superior mesenteric artery, which may become a crucial collateral pathway in cases of celiac axis stenosis. We report a challenging case of a 70-year-old woman presenting with hemorrhagic shock owing to a…
Total Knee Arthroplasty in a patient with anti-synthetase syndrome and severe knee stiffness: A case report.
Anti-synthetase syndrome (ASyS) is a rare autoimmune disorder with diverse clinical manifestations, often initially misdiagnosed as rheumatoid arthritis. Delayed diagnosis may result in severe joint destruction, disabling polymyositis, and even mortality from rapidly progressive respiratory illness.…
Efficacy of Switching from oral to Subcutaneous Methotrexate in Alleviating Methotrexate-related Intolerance Symptoms in Japanese Patients with Rheumatoid Arthritis: The METOJECTIVE Study.
Objectives To investigate the efficacy of switching from oral to subcutaneous methotrexate (MTX) in alleviating MTX-related intolerance symptoms in Japanese patients with rheumatoid arthritis (RA). Methods This non-randomized, prospective, observational study included Japanese patients with RA who e…
Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell-Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Long COVID (LC) is characterized by symptoms persisting at least 3 months after SARS-CoV-2 infection and affecting multiple organ systems. Diagnosis relies on subjective criteria without established biomarkers. Immune dysregulation and mitochondrial dysfunction are implicated in LC pathophysiology.…
Impact of JAK-inhibition on pain and biphasic P2X7R expression on CD4+ T cells in experimental arthritis.
Pain improvement is a major unmet need for patients with rheumatoid arthritis (RA). The purinergic receptor P2 X7R may play a central role in inflammatory pain. We aimed to assess the differential effect of Jak and TNF-α inhibition on pain in a collagen-induced arthritis (CIA) mouse mod…
A novel molluscan CNS organ culture for the examination of adult nerve regeneration.
Central nervous system (CNS) regeneration is crucial for re-establishing neural connections following injury. Though some adult vertebrates have regeneration-competent CNS, invertebrate CNS also provide useful model systems for examining cellular and molecular mechanisms promoting regeneration. Usin…
Bariatric Surgery Versus GLP-1RAs in Idiopathic Intracranial Hypertension: A Propensity Matched Multi-Institutional Cohort.
Idiopathic intracranial hypertension (IIH) is strongly associated with obesity with weight reduction as a central component to management. The relative effectiveness of bariatric surgery (BS) vs glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy remains uncertain. This study aimed to assess…
Association of GLP-1 Receptor Agonist Use With Safety Outcomes in Individuals With Opioid Use Disorder: A Target Trial Emulation.
To evaluate the association between glucagon-like peptide-1 receptor agonist (GLP-1 RA) initiation and adverse gastrointestinal, renal, respiratory and psychiatric outcomes among individuals with opioid use disorder (OUD). This retrospective cohort study was conducted using the MarketScan Comme…