Total Knee Arthroplasty in a patient with anti-synthetase syndrome and severe knee stiffness: A case report.
Anti-synthetase syndrome (ASyS) is a rare autoimmune disorder with diverse clinical manifestations, often initially misdiagnosed as rheumatoid arthritis. Delayed diagnosis may result in severe joint destruction, disabling polymyositis, and even mortality from rapidly progressive respiratory illness.…
Subtype-specific mortality in idiopathic inflammatory myopathies: A hospital-based cohort.
The aim of our study is to compare mortality rates, causes of death and associated risk factors for idiopathic inflammatory myopathies (IIM) and their various subtypes in a hospital-based cohort, specially IMNM (immune-mediated necrotizing myopathy). This retrospective study was conducted using the…
Novel susceptible human leukocyte antigens allele in juvenile dermatomyositis: A study in Japanese patients.
Juvenile dermatomyositis (JDM) exhibits varying clinical features depending on myositis-specific autoantibodies (MSA), with racial differences. The association between JDM and human leukocyte antigen (HLA) has been reported, but data from Japan are lacking. Therefore, this study aimed to investigate…
Understanding online discussions related to pain among patients living with myositis.
Idiopathic inflammatory myopathies (IIM) have historically been considered to cause painless muscle weakness. However, recent studies suggest that pain can be an important symptom for patients with IIM. This study aims to examine the discussions related to myositis and pain on Reddit to understand i…
Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly.
Monoallelic variants in catalytic immunoproteasome subunits have recently been linked to proteasome-associated autoinflammatory syndromes with immunodeficiency (PRAAS-ID), yet their molecular mechanisms and clinical spectra are not fully defined. In this study, seven individuals from five unrelated…
Performance of Large Language Models in Differentiating Systemic Lupus Erythematosus From Mimicking Conditions Using the 2019 EULAR/ACR Criteria: A Comparative Analysis.
Systemic Lupus Erythematosus (SLE) presents a significant diagnostic challenge for clinicians due to its diverse clinical manifestations and overlap with other autoimmune conditions. Large Language Models (LLMs) are currently regarded as having the potential to assist clinicians in expediting decisi…
Progressive Conduction Disease on Serial ECGs Revealing Immune Checkpoint Inhibitor-Associated Myocarditis and Myositis.
Immune checkpoint inhibitors are effective treatments for cancer but also carry cardiovascular toxicity risks. An 83-year-old male receiving cemiplimab for advanced squamous and basal cell carcinoma presented with severe back pain. One week earlier, electrocardiogram (ECG) demonstrated atrial flutte…
Dermatomyositis predominates among checkpoint inhibitor-associated inflammatory myositis phenotypes: a pharmacovigilance disproportionality analysis identifies a class-wide signal.
ICI-induced inflammatory myositis (IIM) is a recognized irAE with significant morbidity and potential for life-threatening overlap syndromes. Whether polymyositis (PM) and dermatomyositis (DM) carry differential pharmacovigilance signals across ICI drug classes has not been systematically examined.…