Proliferative myositis of the biceps brachii: A sarcoma mimicker.
Proliferative myositis is a rare benign intramuscular inflammatory pseudotumor that may clinically mimic a soft tissue sarcoma due to its rapid growth and painful presentation. We report the case of a 50-year-old man presenting with a rapidly enlarging, firm, and painful mass of the left arm, which…
CAR T cell therapy beyond cancer: current status, challenges and future prospects.
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized oncology, and its foundational logic-precise antigen recognition coupled with durable effector activity-extends naturally to chronic non-malignant diseases sustained by long-lived pathological cells. These include viral reservoirs, au…
Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications.
Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-sectional imaging have resh…
Paradigm shift in the pathomechanisms and treatment of inclusion body myositis: at the crossroads of cell-autonomous muscle degeneration and immune activation.
Inclusion body myositis (IBM) is the most prevalent acquired myopathy in adults over 50 years of age, yet effective disease-modifying therapy has remained elusive. The longstanding debate over whether degeneration or inflammation is the primary driver has now given way to a model of bidirecti…
Correction: Furlepa et al. Management of Triple M Syndrome: A Systematic Review with Narrative Synthesis of Immune Checkpoint Inhibitor-Induced Myasthenia Gravis, Myositis and Myocarditis. Cancers 2025, 17, 2063.
Chemoenzymatic Radiosynthesis of a Gluconate Transporter-Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG.
Many bacteria, but not mammalian cells, can directly import and metabolize extracellular gluconate via gluconate permease (GntP) and kinase (GntK). We hypothesized that fluorine-18 labeled gluconic acid ([18F]FGA) could leverage unique bacterial gluconate metabolism for pathogen-specific PET imaging…
Inflammatory Myopathy in a Case of Primary Sjögren's Syndrome on Chronic Statin Therapy: A Diagnostic Challenge and Rare Clinical Presentation.
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease primarily affecting exocrine glands, with less frequent but significant extraglandular manifestations. Among these, inflammatory myopathy (IM) is rare, particularly in biopsy-proven cases. We report the case of a 63-year-old fema…
Proteomic Signatures and an Injury-Stress Endotype in Myositis-Associated Interstitial Lung Disease.
Idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) is a major cause of morbidity and mortality. We tested whether quantitative myositis-specific autoantibodies and proteomic profiling capture biological heterogeneity and prognosis beyond categorical serology. Myositis-sp…