Myositis-specific and myositis-associated autoantibodies in idiopathic inflammatory myopathies: An EASI survey on current clinical and laboratory practices.
Detection of myositis-specific and myositis associated autoantibodies (MSA/MAA) aids in classification, diagnosis, and risk stratification of idiopathic inflammatory myopathies (IIM). To identify opportunities for harmonization, we assessed laboratory and clinical variability in IIM serological test…
Myositis autoantibodies: from new specificities to new paradigms.
Myositis-specific autoantibodies have long been used to classify patients into clinically meaningful subsets; however, recent studies show that the field is moving beyond the simple question of which autoantibody is present. This review examines how emerging specificities, epitope architecture, auto…
Immune checkpoint inhibitor-induced myocarditis with myositis and/or myasthenia gravis overlap syndrome: A case series.
Immune checkpoint inhibitors (ICIs) can lead to immune-related adverse events, including myocarditis with myositis and/or myasthenia gravis overlap syndrome (IM3OS). This syndrome poses notable management challenges and has high mortality rates. Due to limited data, its clinical features and optimal…
A Unique Case of Granulomatosis with Polyangiitis Presenting with Proximal Muscle Weakness.
Granulomatosis with polyangiitis (GPA) is a subtype of ANCA-associated vasculitis that can have a heterogeneous clinical presentation. Although classically involving the respiratory tract and kidneys, GPA can rarely present with predominant skeletal muscle involvement. This is unique given that skel…
Immune-related colitis following head and neck reconstructive surgery in a patient receiving long-term nivolumab.
Immune checkpoint inhibitors (ICIs) are increasingly incorporated into perioperative cancer treatment, raising challenges in distinguishing immune-related adverse events (irAEs) from postoperative complications. We report a case of postoperative immune-related colitis following head and neck reconst…
[Myositis induced by immune checkpoint inhibitor therapy].
Immune-mediated myositis can be a severe side effect of cancer treatment involving immune checkpoint inhibitors (ICI). As a distinct type of rheumatic immune-related adverse events (irAE), it presents challenges in terms of diagnosis and patient management. The high mortality and the poten…
Myositis Ossificans of the Thenar Eminence mimicking a Fracture of an Accessory Trapezium: A Case Report.
Myositis ossificans (MO) is a rare condition characterized by heterotopic ossification within muscle tissue, often mimicking more common pathologies. We present a case of MO involving the thenar eminence, initially suspected and managed as an accessory trapezium fracture. A 66-year-old male presente…