Genetic contributions to systemic autoimmunity are often considered more significant in children than in adults. As such, genetic evaluation may be more frequently pursued in pediatric rheumatology patients. Motivated by the discovery of a STING-associated vasculopathy with onset in infancy (SAVI) m…
French NOMADMUS Cohort Overview: Landscape Evolution of AQP4+NMOSD and MOGAD From 2010 to 2024.
Aquaporin 4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare conditions with evolving diagnostic and therapeutic approaches. Our study aims to describe these evolutions in France, us…
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS-CoV-2 Infection-A Case Report.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex neuroimmunological disorder characterized by disabling symptoms that are often difficult to manage. More recently, in the context of SARS-CoV-2 infection, potential pathophysiological overlaps and disease modulation have been h…
Machine learning prediction of dual absorber lead-free perovskite solar cells for boosting PCE.
Curtailing the toxicity level of perovskites is a considerable obstacle resisting the wide-scale commercialization of perovskite solar cells (PSCs). This study investigates the impact of implementing several charge transport layers (CTLs) on the performance of the proposed lead-free Cs2TiCl6/ Cs2AgB…
DNA-Engineered Dual-Signal Biomimetic Fusion Vesicles for Rapid Evaluation of Systemic Lupus Erythematosus.
Systemic lupus erythematosus (SLE) is a rare autoimmune disease with complex and variable clinical presentations that affects numerous organs and tissues. However, current diagnostic approaches provide limited insight into disease-associated molecular alterations and immune pathway activation. In th…
Cost Analysis of an Outpatient MRI Pathway for Optic Disc Edema: A Time-Driven Activity-Based Costing Approach.
To compare the costs and efficiency of an outpatient STAT neuroimaging pathway against traditional emergency department (ED)-based neuroimaging for patients with optic disc edema. Retrospective cost analysis using time-driven activity-based costing (TDABC) methodology. One-hundred twenty-nine patien…
Sexually dimorphic roles of toll-like receptors in the central nervous system.
Many neurological and psychiatric diseases and disorders show sex differences in prevalence, incidence, disease manifestation and response to treatment. Yet, historically, most clinical and pre-clinical studies have been conducted disproportionately or exclusively in male subjects. In recent years,…
Assessment of readiness in the diagnosis and management of central disorders of hypersomnolence: A survey of sleep medicine program directors and fellowship graduates.
Central disorders of hypersomnolence (CDH), including narcolepsy, idiopathic hypersomnia, and recurrent hypersomnia, are rare conditions that pose challenges in sleep medicine fellowship training. Limited exposure to these disorders, variability in training experiences, and growing complexity of dia…