Antiphospholipid Syndrome

Re-evaluating low-molecular-weight heparin use in recurrent missed miscarriage: current evidence and future directions.

Recurrent missed miscarriage (RMM) is heterogenous and emotionally burdensome. Low-molecular-weight heparin (LMWH) plus low-dose aspirin improves live-birth rates in women with obstetric antiphospholipid syndrome (APS), but the value of the use of LMWH in APS-negative RMM with and without confirmed…

Cross-sectional imaging in an inferior vena cava agenesis associated with antiphospholipid syndrome, lower limb, and portomesenteric deep vein thrombosis and renal insufficiency in a young patient: A rare presentation.

Inferior vena cava (IVC) agenesis is a rare congenital anomaly (prevalence 0.0005%-1%) often asymptomatic but can be complicated by deep vein thrombosis, particularly in the presence of acquired thrombophilia. There are 2 major presentations reported in literature, infrahepatic IVC agenesis associat…

Comparative efficacy and safety of direct oral anticoagulants versus warfarin in non-valvular atrial fibrillation patients with adult congenital heart disease. Contemporary real-world propensity-matched retrospective cohort study.

Adults with congenital heart disease (ACHD) have a rising prevalence of atrial fibrillation/flutter (AF) and elevated thrombotic and bleeding risk. Although direct oral anticoagulants (DOACs) are established in non-ACHD AF, comparative effectiveness in ACHD is not well defined. In a propensity score…

Management of systemic lupus erythematosus and antiphospholipid syndrome during CAR-T therapy: insights from two clinical cases.

Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are autoimmune disorders marked by the presence of pathogenic autoantibodies predominantly produced by B cells. Both conditions are chronic, incurable, and require lifelong treatment. Chimeric antigen receptor T-cell (CAR-T) ther…

Catastrophic Outcome of Pregnancy Complicated With Tricuspid Valve Nonbacterial Thrombotic Endocarditis.

Nonbacterial thrombotic endocarditis (NBTE) is a rare condition characterized by sterile fibrin-platelet vegetations on cardiac valves, typically associated with hypercoagulable states. Isolated tricuspid valve (TV) involvement during pregnancy is exceedingly rare, with no previously reported cases…

Classification performance of the 2023 ACR/EULAR antiphospholipid syndrome criteria: a systematic review and meta-analysis.

To systematically evaluate the classification performance of the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for antiphospholipid syndrome (APS). We conducted a systematic review of literature from August 2023 through M…

Lupus anticoagulant testing pre- and post-direct oral anticoagulants removal procedure in patients suspected of antiphospholipid syndrome: a real-life experience.

Rituximab-induced hypogammaglobulinemia in autoimmune cytopenia and associated diseases.

Rituximab is used for treating autoimmune cytopenia and associated diseases including autoimmune haemolytic anaemia; immune thrombopenia, systemic lupus erythematosus and antiphospholipid syndrome. However, rituximab may induce acquired immune deficiency in some patients, particularly hypogammaglobu…