Re-evaluating low-molecular-weight heparin use in recurrent missed miscarriage: current evidence and future directions.
Recurrent missed miscarriage (RMM) is heterogenous and emotionally burdensome. Low-molecular-weight heparin (LMWH) plus low-dose aspirin improves live-birth rates in women with obstetric antiphospholipid syndrome (APS), but the value of the use of LMWH in APS-negative RMM with and without confirmed…
Systemic inflammation increases mast cell numbers in coronary arteries in patients who died from myocardial infarction.
Systemic inflammation caused by infection peaks the risk of acute myocardial infarction (AMI), presumably by affecting atherosclerotic plaque (AP) stability. In this study, APs were examined in AMI patients with acute infection (AI). Four groups of AMI patients with or without AI were compared to de…
Multiterritory Acute Ischemic Stroke with Bilateral Middle Cerebellar Peduncle T2/FLAIR Hyperintensities in the Setting of a Fatal Systemic Arterial Thrombotic Process: A Case Report.
Ischemic stroke under 55 years presents a distinct etiological challenge with higher prevalence of non-atherosclerotic causes. We report a fatal case of multiterritory acute cerebral infarction with bilateral middle cerebellar peduncle (MCP) T2/FLAIR hyperintensities in a 50-year-old woman, pursuing…
Autoimmune-associated thrombosis: mechanisms, population burden, and prevention strategies.
Autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, and systemic vasculitis, are associated with increased risk of thrombosis, accelerated atherosclerosis, cardiovascular-events, and premature mortality. Heparin-induced thrombocytopaenia and…
Carrageenan-induced immunothrombotic models in rodents (Review).
Carrageenan (CGN)-induced immunothrombotic models are used in rodent thrombosis research. They enable both mechanistic dissection of inflammation-coagulation crosstalk and high-throughput screening of antithrombotic agents. The present narrative review summarizes current knowledge on modeling approa…
Anticoagulation quality in antiphospholipid syndrome according to INR testing strategy.
Uncertainty exists regarding the accuracy and clinical utility of point-of-care (POC) International Normalized Ratio (INR) testing in patients with antiphospholipid syndrome (APS) prescribed warfarin. The objective of this study was to evaluate anticoagulation quality among APS patients using differ…
Experiences of pregnancy and family planning in patients with antiphospholipid antibodies and antiphospholipid syndrome.
BackgroundWomen with antiphospholipid antibodies (aPL) and antiphospholipid syndrome (APS) are at increased risk of pregnancy complications. Routinely reported endpoints primarily captures what happens medically but provide limited insight into the experience of the emotional, psychosocial and lived…