Pain management in pancreatic cancer: time to change our strategy!
Pain affects 70-80% of patients with pancreatic adenocarcinoma and remains inadequately controlled in more than half of cases. Beyond its impact on quality of life, pain is now recognized as an independent prognostic factor, reflecting the unique neurobiological features of this malignancy. Perineur…
Oromucosal Administration of a Cannabidiol-Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain.
Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of the endocannabinoid system. Cannabis-based products have emerged as promising therapeutic options, but their effects on immune cells remain unclear. This study evaluate…
Genetic contributions to systemic autoimmunity are often considered more significant in children than in adults. As such, genetic evaluation may be more frequently pursued in pediatric rheumatology patients. Motivated by the discovery of a STING-associated vasculopathy with onset in infancy (SAVI) m…
Too high and too loose: dysautonomia and the hypertensive paradox in hypermobility disorders.
Hypertension in hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) represents an increasingly recognized but poorly understood clinical phenomenon. This review addresses the unique pathophysiology, diagnostic considerations, and management challenges of hypertension…
Pulsed radiofrequency for treatment of complex regional pain syndrome: A scoping review.
Complex Regional Pain Syndrome (CRPS) is a debilitating chronic pain condition characterized by sensory, motor, and autonomic disturbances, often resistant to conventional therapies. Pulsed radiofrequency (PRF), a non-neurodestructive neuromodulation technique, has been described as a potential inte…
Clinician perspectives on Long-COVID physical rehabilitation: challenges, uncertainty, and semantics.
To understand the perspectives of clinicians who provided rehabilitation services to people with Long-COVID or referred people to such services. Clinicians involved with Long-COVID rehabilitation were recruited via email and interviewed. Recruitment continued until thematic saturation on physical re…
Systematic review of diffusion tensor imaging in spina bifida myelomeningocele: clinical implications in the era of prenatal repair.
Spina bifida myelomeningocele (SBM) is a neural tube defect associated with altered brain development and impaired cognitive function. Structural brain abnormalities in SBM are well documented but less is known about potential white matter abnormalities. Diffusion tensor imaging (DTI) is a unique MR…
Involvement of the External Ear by inflammatory Skin Diseases.
Chronic inflammatory skin disorders cover both frequent and rare dermatoses. The etiopathology of these diseases is broad and ranges from genetic factors to environmental and life-style issues. In this review, we focus on affections of the auricle by the eczema group, psoriasis, and pityriasis rubra…