Isolated nasal septal involvement in granulomatosis with polyangiitis: Radiologic features and literature review.
Granulomatosis with polyangiitis is a necrotizing granulomatous vasculitis that predominantly involves the upper and lower respiratory tracts and the kidneys. Although sinonasal manifestations are common, they are often nonspecific and can mimic benign inflammatory conditions, leading to delayed dia…
Large vessel vasculopathy: An underrecognized complication in Wiskott-Aldrich syndrome.
Autoimmune manifestations occur in 25-75% of patients with Wiskott-Aldrich syndrome (WAS), commonly including autoimmune hemolytic anemia, skin vasculitis, IgA nephropathy, arthritis, and inflammatory bowel disease. Large vessel vasculopathy is rarely reported in WAS. We present a review of children…
Intensive Care Unit Management of Meningitis and Encephalitis.
Meningitis and encephalitis are neurologic emergencies that require rapid recognition and treatment. Prompt diagnosis and administration of antimicrobials, alongside adjuvant steroids in select cases, are crucial for treatment and improvement in outcomes. Severe complications of meningitis and encep…
Haploinsufficiency of A20 (HA20) is a primary immune regulation disease caused by heterozygous loss-of-function variants in TNFAIP3, resulting in unchecked inflammatory signaling. HA20 is a highly heterogeneous disorder with overlapping features of autoinflammation, autoimmunity, immunodeficiency, a…
Burden of incident cardiovascular events in giant cell arteritis using data from a nationwide French cohort.
Giant cell arteritis (GCA) is one of the most common adult vasculitis. As large-scale studies on cardiovascular events in GCA are missing in France, our study examine their incidence using the French national medico-administrative health database. We included patients hospitalized for GCA between Ja…
Pneumocystis jirovecii pneumonia (PJP) is a rare and potentially fatal opportunistic infection in patients with rheumatic diseases with mortality rates exceeding those seen in HIV-infected patients. Although PJP prophylaxis is highly effective, evidence-based guidelines specific to rheumatic disease…
Incidental detection of Takayasu arteritis in a hypertensive pregnancy with recurrent pregnancy loss: a positive maternal outcome.
Takayasu arteritis, which is also known as aortic arch syndrome, non-specific aortoarteritis and pulseless disease, is a rare chronic inflammatory progressive large vessel vasculitis of likely autoimmune aetiology causing narrowing, occlusion and aneurysms of systemic and pulmonary arteries, especia…
Visual analysis of [18F]FDG PET/CT imaging yields superior diagnostic accuracy compared to semiquantitative analysis in the assessment of giant cell arteritis.
[¹⁸F]FDG PET/CT can be used to diagnose suspected new-onset giant cell arteritis (GCA), but it is unclear, whether visual or semiquantitative evaluation yields the highest accuracy. We therefore aimed to compare both methods with regard to diagnostic accuracy within the same patient. Thi…