Immune regulatory mechanisms and potential microbiota-associated targets in Kawasaki disease: an integrative multi-omics and network pharmacology study.
Kawasaki disease (KD) is a systemic vasculitis in children primarily affecting the coronary arteries, and studies suggest that the gut microbiota may be involved in KD pathogenesis, inflammatory responses, and immune regulation. This study employed an integrative multi-omics strategy to systematical…
Navigating complex presentations of central nervous system tuberculosis: A two-case analysis.
Tuberculosis (TB) remains a significant global health concern, and the COVID-19 pandemic has negatively impacted TB control. This report presents 2 challenging cases of central nervous system (CNS) tuberculosis with atypical presentation in adult patients. The first case involved a young male patien…
ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype.
Deficiency of adenosine deaminase 2 (DADA2) is an autoinflammatory disease with diverse phenotypes. We describe the genetics, phenotypes, and treatment of n = 48 DADA2 patients from Germany, Austria, and Switzerland. We report a high incidence of hematological (83%) and immunological features (85%),…
Migration of perivenous opacities during retinal vasculopathy and retinal vasculitis.
To report the migration of perivascular opacities, in patients with retinal vasculopathy, with and without clinical evidence of ocular inflammation. Retrospective case series of four patients with either idiopathic retinal vasculitis or presumed retinal vascular inflammation. Patients were imaged wi…
Microscopic Polyangiitis With Pituitary Dysfunction and Spontaneous Renal Aneurysm Rupture.
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a relatively uncommon autoimmune disease, predominantly causing kidney or lung injury. Pituitary dysfunction is exceedingly rare in microscopic polyangiitis (MPA). Rupture or hemorrhage of renal artery aneurysms is also sc…
Nonsystemic Vasculitic Neuropathy Presenting as Inflammatory Demyelinating Polyradiculoneuropathy.
Nonsystemic vasculitic neuropathy classically presents as a painful asymmetric axonal neuropathy, multiple mononeuropathies or radiculoplexus neuropathy. Demyelinating electrophysiologic features are rare and may lead to misdiagnosis. We describe a patient with biopsy-proven vasculitic neuropathy pr…