Elevated Serum Soluble CD163 Indicates Macrophage Activation: A Potential Biomarker for Inflammation in Complex Regional Pain Syndrome?
Several studies point towards the involvement of the immune system (especially the monocyte-macrophage system) in the pathophysiology of Complex Regional Pain Syndrome (CRPS), as shown by increased levels of the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6. These cytokines ar…
A New Mouse Model of Complex Regional Pain Syndrome With the Prolonged Pain In Spite of Recovering Skin Inflammation.
Complex regional pain syndrome (CRPS) is a chronic pain disorder that usually affects the limbs after injury, surgery or wearing a cast. However, currently, there are no effective treatments or drugs. No animal model mimics these symptoms and shows stable pain-like symptoms for the evaluation of the…
Maternal and fetal outcomes of spinal cord stimulation in pregnancy: systematic review with descriptive meta-analysis.
Spinal cord stimulation (SCS) is an established therapy for refractory neuropathic pain and is increasingly used in women of reproductive age. However, evidence regarding the safety of SCS during pregnancy remains limited, and consolidated outcome data are lacking. Our objective was to systematicall…
Incidence and etiology of impediments to spinal cord stimulator trial progression.
Spinal cord stimulator (SCS) trials are used to assess therapy efficacy before permanent implantation. Despite initial candidacy, not all patients proceed to SCS trial. Comprehending potential barriers to SCS therapy could offer strategies to enhance patient access. The purpose of this study is to e…
Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.
Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients. The aim of this study was…
Integrating Ketamine and Autogenic Training for Chronic Pain: A Case Study at Walter Reed National Military Medical Center.
Ketamine has demonstrated efficacy in managing chronic pain and, when combined with psychotherapy, alleviating psychiatric symptoms. However, no published studies have examined the integration of ketamine infusion with autogenic training for chronic pain management. This case study evaluated the fea…
Timing of Achilles Tendon Revision within 2 Months of Primary Repair Affects Incidence of Acute Complications.
Early revision of primary Achilles tendon repair is sometimes necessary, and the Achilles tendon's inherent hypovascularity creates a uniquely challenging biological environment for reoperation. However, the optimal timing for revision and its associated complication risks remain poorly characterize…
[Interventional pain treatment in Austria : Results of a survey among specialized pain therapists].
Interventional procedures are an integral component of multimodal pain management; however, their clinical use and indications remain controversial due to heterogeneous evidence regarding their efficacy. Until now, no systematic data have been available on the prevalence and clinical practice of int…