Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.
Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients. The aim of this study was…
Elevated Serum Soluble CD163 Indicates Macrophage Activation: A Potential Biomarker for Inflammation in Complex Regional Pain Syndrome?
Several studies point towards the involvement of the immune system (especially the monocyte-macrophage system) in the pathophysiology of Complex Regional Pain Syndrome (CRPS), as shown by increased levels of the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6. These cytokines ar…
Maternal and fetal outcomes of spinal cord stimulation in pregnancy: systematic review with descriptive meta-analysis.
Spinal cord stimulation (SCS) is an established therapy for refractory neuropathic pain and is increasingly used in women of reproductive age. However, evidence regarding the safety of SCS during pregnancy remains limited, and consolidated outcome data are lacking. Our objective was to systematicall…
Incidence and etiology of impediments to spinal cord stimulator trial progression.
Spinal cord stimulator (SCS) trials are used to assess therapy efficacy before permanent implantation. Despite initial candidacy, not all patients proceed to SCS trial. Comprehending potential barriers to SCS therapy could offer strategies to enhance patient access. The purpose of this study is to e…
A Review of Physiological Measurements Among Patients Diagnosed With Complex Regional Pain Syndrome.
The combination of disproportionate pain intensity and limb disuse is often diagnosed as complex regional pain syndrome (CRPS), a label that may imply a specific measurable pathophysiology. In a review of studies of pathophysiology associated with diagnosis of CRPS, we asked, "How often are studies…
Complex regional pain syndrome research trends: A bibliometric analysis of the last 3 decades (1993-2025).
Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by disproportionate regional pain and distinct clinical features such as allodynia and hyperalgesia. We conducted a bibliometric analysis to map the global research landscape of CRPS over the past 3 decades, with an addit…
Why do bisphosphonates work in the treatment of CRPS? A translational pharmacological perspective to solve a conundrum.
Bisphosphonates (BPs) have consistently yielded positive results in the treatment of Complex Regional Pain Syndrome (CRPS). However, biochemical and histopathological evidence suggests that osteoclasts, the primary pharmacological target of BPs, is not a key driver in the early pathogenetic steps of…