The Burden of Small Fiber Neuropathy: Changes in Pain, Costs, and Quality of Life Before and After Diagnosis.
Small fiber neuropathy (SFN) is a peripheral neuropathy causing neuropathic pain, reduced quality of life (QoL), and high societal costs. Previous studies assessed these societal costs before a definitive diagnosis was established, leaving it unclear whether diagnostic confirmation affects costs, pa…
Use of Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy: A Systematic Review of Current Clinical Evidence.
Small fiber neuropathy (SFN) is a clinically heterogeneous and difficult-to-manage condition for which intravenous immunoglobulin (IVIG) is increasingly used despite inconsistent evidence and substantial cost. We therefore systematically evaluated the clinical effectiveness of IVIG in SFN, with atte…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
dysautonomiasarcoidosissmall fiber neuropathybrain fog
Autonomic and small fiber neuropathy in patients with acute hepatic porphyrias.
Neurovisceral pain and autonomic symptoms are the initial and most common symptoms of acute hepatic porphyrias (AHPs) attacks. These symptoms may also exist in between attacks. Autonomic dysfunction in AHPs has been evaluated previously, but systematic evaluation with modern methods has been lacking…
Sarcoidosis is a multisystem disease characterised by a heterogeneous clinical presentation and variable disease course. Despite low mortality, the burden of sarcoidosis extends beyond organ involvement, with many patients reporting significant impairment in quality of life (QoL). Fatigue, chronic c…
Autoantibodies in small fiber neuropathy: frequency and clinical features associated with antibodies to the novel targets MX1 and DBNL.
Small fiber neuropathy (SFN) is characterized by neuropathic pain and autonomic dysfunction. Emerging evidence suggests a potential autoimmune component, although a limited number of autoantibody targets have been implicated so far. This study aimed to investigate the prevalence of antibodies agains…
Distinct sensory and autonomic involvement in hypermobile Ehlers-Danlos syndrome compared with idiopathic small fiber neuropathy: a multimodal study.
Hypermobile Ehlers-Danlos syndrome (hEDS), frequently presents with pain and autonomic symptoms suggestive of small fiber neuropathy (SFN). However, systematic comparisons between hEDS and idiopathic SFN (iSFN) using combined clinical, functional, and morphological approaches are lacking. We prospec…
Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving slingshot protein phosphatase 1b enrichment.
Depleted uranium (DU) is an environmental contaminant with a 30 µg/L (ppb; parts per billion) EPA maximum contaminant level (MCL) for drinking water. The mining of uranium and use of DU in modern weapons underly human exposure that disproportionally impacts military and tribal communities in th…