Small Fiber Neuropathy

Too high and too loose: dysautonomia and the hypertensive paradox in hypermobility disorders.

Hypertension in hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) represents an increasingly recognized but poorly understood clinical phenomenon. This review addresses the unique pathophysiology, diagnostic considerations, and management challenges of hypertension…

Neuropathic involvement in wild-type transthyretin amyloidosis.

Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) has traditionally been considered a purely cardiological condition. However, recent studies suggest that neurological involvement in ATTRwt amyloidosis is more significant than previously believed. We conducted a comprehensive neurological stu…

Abnormal genital arousal and sensory symptoms in patients with autonomic disorders and comorbidities.

Acute Small Fiber Neuropathy With Severe Autonomic Dysfunction at the Interface of Guillain-Barré Syndrome.

Dual-Lead Spinal Cord Stimulation for Refractory Diabetic Small Fiber Neuropathy With Erythromelalgia-Like Features: A Case Report.

Small fiber neuropathy is a painful diabetes complication that may present with burning pain, dysesthesia, and autonomic features such as swelling, color changes, and hyperhidrosis. Some cases overlap with erythromelalgia, a rare condition marked by episodic erythema, temperature sensitivity, and va…

Effectiveness of Current Diagnostic Methods in the Early Detection of Diabetic Peripheral Neuropathy: Are We Missing the Window?

Diabetic peripheral neuropathy (DPN) is one of the most common long-term complications of diabetes and a major cause of foot ulceration, pain, balance impairment, and lower-limb amputation. Nerve injury may begin early, but many patients remain undiagnosed until they already have clinically importan…

Exploring the differential diagnosis of generalized diabetic peripheral neuropathy.

Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes mellitus and is frequently assumed to be the sole cause of neuropathic symptoms in patients with diabetes. This diagnostic simplification may lead to misdiagnosis, delayed treatment of alternative etiologies, an…

Dorsal Root Ganglion Stimulation for the Treatment of Burning Feet Syndrome Related to Erythromelalgia.

Erythromelalgia (EM) is a very rare condition characterized by severe paroxysmal pain in the upper or lower extremities and erythema, resulting in significant morbidity and incapacity. Typically, multiple specialty evaluations rule out competing autoimmune, inflammatory, and neuropathic etiologies.…