Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial.
Vestibulodynia (VBD) is a common chronic pelvic pain condition with heterogeneous clinical presentation, including subtypes distinguished by the presence (VBD-central; VBD-c) or absence (VBD-peripheral; VBD-p) of comorbid pain conditions. Despite frequent prescribing of topical therapies such as lid…
A meta-analysis of pain intensity changes after placebo interventions in facial pain.
Interpreting pain improvements after interventions in clinical settings is challenging because placebo effects can influence patient-reported outcomes. In clinical practice, pain intensity reductions of 30% or greater are commonly considered indicative of meaningful analgesic benefit. However, the l…
Disability, Fatigue and Mental Health in Acute Versus Chronic Spinal Pain in the Gaza Strip: A Comparative Cross-Sectional Study.
Spinal pain is a major contributor to disability, but evidence comparing multidomain outcomes across acute and chronic stages remains limited in conflict-affected settings. This study aimed to compare disability, fatigue, psychological distress and sleep disturbance among patients with acute and chr…
Nanoparticle-based therapeutic platforms for inflammatory disorders of the urinary system: Engineering local delivery, biointerface regulation, and smart responsive therapy.
Inflammatory diseases of the urinary system, including urinary tract infection (UTI), catheter-associated urinary tract infection (CAUTI), interstitial cystitis/bladder pain syndrome (IC/BPS), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), are associated with high recurrence, comple…
Alcohol use in adolescent chronic pain: Prevalence rates, perceptions of risk, and predictors of use.
Alcohol use (AU) in pediatric chronic pain may exacerbate pain and impact adult substance use behavior. This study characterizes prevalence rates and biopsychosocial correlates of AU in adolescents with chronic pain. Cross-sectional survey study comprising adolescents aged 14-19 with chronic pain fr…
Thwarted credibility work and double binds in medically unexplained pain in Japan: a qualitative study.
This study examined how people living in Japan with medically unexplained pain (MUEP) perform credibility work across clinics and everyday life, where and why credibility work falters, and the interactional double binds organizing these failures. We qualitatively analyzed first-person illness narrat…
Localized surface-based morphometric differences in painful temporomandibular disorder.
Temporomandibular disorders (TMDs) are prevalent chronic orofacial pain conditions associated with functional impairment and reduced quality of life. This cross-sectional brief report examined cortical and subcortical morphometric differences between 19 individuals with painful TMD (p-TMD) and 20 ag…
Prevalence and Correlates of Suicidal Distress in Adolescents in a Chronic Pain Service.
Chronic pain is increasingly recognized as an independent correlate of suicidality in adolescence, yet most evidence comes from community-based studies. This observational, cross-sectional study (NCT04261114) explored the prevalence and correlates of suicidal distress in a pediatric pain service. Ad…