Real-world all-cause healthcare resource utilization and costs among patients with interstitial cystitis/bladder pain syndrome in the United States.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a persistent and heterogeneous condition diagnosed by exclusion, defined by a bladder-associated unpleasant sensation (e.g. pain, pressure, or discomfort), and affecting patients' quality of life. This real-world study aimed to describe all-cau…
Network analysis of multisite chronic pain in middle-aged and older adults in Western China.
Multisite chronic pain (MCP) is a growing public health concern among aging populations worldwide, disproportionately affecting underdeveloped regions of low- and middle-income countries where pain awareness and management capacity remain limited. This study aimed to investigate MCP prevalence and c…
Exercise attenuates neuropathic pain and neuroinflammation in an obese rat model exhibiting diabetes-related metabolic dysfunction and features of type 2 diabetes.
This study aimed to investigate the effects and mechanisms of exercise intervention on neuropathic pain in an obese rat model exhibiting diabetes-related metabolic dysfunction. Chronic constriction injury (CCI) was induced in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and the animals were rando…
Encephalopathy following subcutaneous administration of Brixadi® extended-release buprenorphine.
Long-acting injectable buprenorphine is one option for the management of opioid use disorder. The United States Food and Drug Administration has approved two brands for monthly injection, Sublocade ® (Indivior, North Chesterfield, VA, USA) and Brixadi® (Braeburn, Plymouth Meeting, PA, USA)…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Exploring oxidative and antioxidant biomarkers in temporomandibular joint disorders: An exploratory systematic review across multiple biological fluids.
To determine if oxidative stress markers are consistently altered in TMD patients compared to healthy controls, by synthesizing evidence from blood, saliva, and synovial fluid analyses and assessing study quality. Following PRISMA guidelines, Medline/PubMed, Scopus, Web of Science, Google Scholar, C…
Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia.
Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions. We prospectively enrolled…
Dorsal scapular nerve entrapment: a systematic review.
Periscapular and interscapular pain are common musculoskeletal complaints; however, dorsal scapular nerve (DSN) entrapment neuropathy remains an under-recognized and frequently overlooked etiology. DSN pathology may mimic multiple cervical, shoulder, and upper-extremity disorders, resulting in delay…