Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis.
This cross-sectional study investigated galectin-1, -3, and -9 in adenomyosis. Analysis of hysterectomy tissues from premenopausal women via western blot, qPCR, immunohistochemistry, and Masson's staining revealed significantly elevated galectin levels compared to controls. Galectin expression posit…
Pharmacological targeting of the TLR8/AP-1 axis ameliorates scleroderma skin inflammation and fibrosis by suppressing monocyte-mediated endothelial injury.
Toll-like receptor 8 (TLR8) is implicated in systemic sclerosis (SSc) pathogenesis, but its precise cellular mechanisms remain elusive. This study elucidates TLR8's role in monocyte-endothelial crosstalk and evaluates the therapeutic potential of targeting the TLR8/AP-1 axis in SSc. TLR expression i…
Prevalence and incidence of fibromyalgia and associated severity in the United States using MarketScan.
Fibromyalgia is characterized by a range of symptoms, the most prominent being chronic widespread pain, fatigue, and unrefreshing sleep. This study estimated the diagnosed annual prevalence, incidence, and severity of fibromyalgia among adults (≥18 years) and the pediatric population (<18 yea…
Co-existing limited dorsal myeloschisis, spinal dermal sinus tract, and dermoid cyst in a 3-month-old female infant: Illustrative case.
Limited dorsal myeloschisis (LDM) and spinal dermal sinus tracts (DST) are rare forms of closed spinal dysraphism that are usually considered distinct entities, and their coexistence with a dermoid cyst is exceptionally uncommon. We describe a 3-month-old female infant with a congenital lumbosacral…
Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.
Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway. This study included 201 women with fibr…
FMultifunctional magnetic resonance imaging for the assessment of renal pathological alterations in IgA nephropathy.
We aimed to evaluate the application value of multiparametric diffusion weighted magnetic resonance imaging (MRI) for the assessment and risk stratification of renal histopathological injuries in patients with IgA nephropathy (IgAN), as an exploratory study. 95 patients were prospectively enrolled,…
Analysis of changes in glomerular lesions in children diagnosed with IgA nephropathy following immunosuppressive therapy.
The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute inflammatory lesions and milder chronic injuries. This study aimed to evaluate…
MRPS22 variants alter mitochondrial ribosome assembly in patients with leukodystrophy, movement disorder and intellectual impairment.
Mitochondrial diseases are clinically and genetically heterogeneous, often complicating diagnosis. Here, we describe four unrelated individuals with suspected mitochondrial disease who shared similar neuroimaging features, including bilateral symmetrical supra- and infratentorial white-matter abnorm…