Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.
Osteoarthritis (OA) is associated with some comorbidities. However, the consistency of the associations across different countries is unclear. We analysed relationships between OA and 61 comorbidities before and after diagnosis using data from four European primary care databases: the UK, the Nether…
Effects of N-methyl-d-aspartate receptor modulation on brain glutamate, functional connectivity, and clinical symptoms in fibromyalgia.
This exploratory, 2-site phase 2 clinical trial investigated whether neuroimaging biomarkers could demonstrate the analgesic potential of NYX-2925, a novel N-methyl-d-aspartate receptor modulator, in women with fibromyalgia. Twenty-two participants completed sequential 2-week treatment periods: plac…
Does maladaptive microvascular flow redistribution cause tissue hypoxia in fibromyalgia?
Fibromyalgia is a chronic pain syndrome characterized by widespread pain, fatigue, and cognitive complaints often described by patients as "brain fog". In the absence of specific physiological, laboratory, or imaging markers, diagnosis remains clinical. Despite extensive investigation, its underlyin…
The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury.
Traumatic brain injury (TBI) alters neuroimmune physiology resulting in an imbalance between pro- and anti-inflammatory cascades. Whereas acute inflammation serves as an adaptive defense mechanism of the innate immune system to promote healing and restore homeostasis after injury, unresolved pro-inf…
Longitudinal stability of data-driven fibromyalgia phenotypes across repeated clinical assessments.
Fibromyalgia is a heterogeneous chronic condition characterized by variability in pain, psychological distress, central sensitization, and functional impairment. Cross-sectional studies have identified reproducible symptom phenotypes; however, their longitudinal stability remains incompletely unders…
A scoping review on the characteristics of chronic pain registries.
Chronic pain represents a major global public health challenge, yet systematic surveillance through patient registries remains unevenly developed. Pain registries offer valuable real-world data to inform clinical practice, research, and policy; however, their global scope, design characteristics, an…
Central sensitization in long COVID: Associations with autonomic symptom burden, cerebral hypoperfusion, and neuroinflammation.
The mechanisms driving the broad spectrum of Long COVID symptoms-such as fatigue, brain fog, pain, and dysautonomia-remain uncertain. This study investigated central sensitization (CS) as a potential contributor to symptom burden in patients with Long COVID. We aimed to examine its association with…
IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study.
Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical profiles. We recruited 30 FM patients an…