A scoping review on the characteristics of chronic pain registries.
Chronic pain represents a major global public health challenge, yet systematic surveillance through patient registries remains unevenly developed. Pain registries offer valuable real-world data to inform clinical practice, research, and policy; however, their global scope, design characteristics, an…
Longitudinal stability of data-driven fibromyalgia phenotypes across repeated clinical assessments.
Fibromyalgia is a heterogeneous chronic condition characterized by variability in pain, psychological distress, central sensitization, and functional impairment. Cross-sectional studies have identified reproducible symptom phenotypes; however, their longitudinal stability remains incompletely unders…
The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury.
Traumatic brain injury (TBI) alters neuroimmune physiology resulting in an imbalance between pro- and anti-inflammatory cascades. Whereas acute inflammation serves as an adaptive defense mechanism of the innate immune system to promote healing and restore homeostasis after injury, unresolved pro-inf…
Does maladaptive microvascular flow redistribution cause tissue hypoxia in fibromyalgia?
Fibromyalgia is a chronic pain syndrome characterized by widespread pain, fatigue, and cognitive complaints often described by patients as "brain fog". In the absence of specific physiological, laboratory, or imaging markers, diagnosis remains clinical. Despite extensive investigation, its underlyin…
Effects of N-methyl-d-aspartate receptor modulation on brain glutamate, functional connectivity, and clinical symptoms in fibromyalgia.
This exploratory, 2-site phase 2 clinical trial investigated whether neuroimaging biomarkers could demonstrate the analgesic potential of NYX-2925, a novel N-methyl-d-aspartate receptor modulator, in women with fibromyalgia. Twenty-two participants completed sequential 2-week treatment periods: plac…
Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.
Osteoarthritis (OA) is associated with some comorbidities. However, the consistency of the associations across different countries is unclear. We analysed relationships between OA and 61 comorbidities before and after diagnosis using data from four European primary care databases: the UK, the Nether…
Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society.
This practice guideline provides updated evidence-based recommendations regarding the use of pharmacologic migraine prevention in adults. A multidisciplinary panel conducted a systematic review and developed practice recommendations following the process outlined in the 2017 edition of the American…
Preliminary Investigation of Disorders of Gut-Brain Interaction and Their Associations With Psychological Flexibility and Daily Functioning in People With Fibromyalgia.
A substantial proportion of people with fibromyalgia also experience comorbid disorders of gut-brain interaction (DGBIs), which can lead to considerable personal and societal burdens. However, evidence regarding the implications of this comorbidity remains limited. The aim of this study was to inves…