ME/CFS

Making recovery conceivable: perspectives from healthcare professionals using psychologically and behaviourally informed approaches to chronic fatigue syndrome.

Healthcare professionals (HCPs) treating patients with chronic fatigue syndrome (CFS) work within a contested field marked by uncertainty. This study explored how HCPs using psychologically and behaviourally informed approaches to CFS understood therapeutic change and their role in facilitating reco…

Exploratory clinical and immunological changes following Tixagevimab/Cilgavimab administration in immunodeficient patients with SARS-CoV-2-associated ME/CFS and persistent circulating spike protein.

Persistent circulating SARS-CoV-2 spike protein has been proposed as a potential contributor to long-COVID pathophysiology. Whether administration of spike-targeting monoclonal antibodies is followed by changes in spike protein concentrations, autonomic receptor autoantibodies, or clinical outcomes…

[Dysautonomia and hypopallesthesia in myalgic encephalomyelitis/chronic fatigue syndrome: a case report].

Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.

Fatigue is a frequent and disabling symptom across many physical and mental health conditions. Despite similar phenomenology, research has largely focused on single conditions using heterogeneous assessments, limiting cross-condition comparability. This study examines fatigue-related symptom burden…

Rehabilitative efficacy of cognitive behavioral therapy-based intervention for chronic fatigue syndrome: A systematic review and meta-analysis.

Cognitive behavioral therapy (CBT) has been used for chronic fatigue syndrome (CFS), but previous studies have shown inconsistencies and divergent long-term outcomes. This study aims to assess the effectiveness of CBT in improving fatigue, physical functioning, and psychological health in patients w…

Characterizing Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Symptom Burden, Functional Impairment, and Comparison With Adults in the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study.

To characterize the clinical, functional, and educational characteristics of adolescents with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and compare selected illness domains with adults in the Multi-Site Clinical Assessment of ME/CFS (MCAM) study. Baseline cross-sectional data from…

Gut microbiome-immune-metabolic axis in fatigue: mechanistic insights and food science approaches.

Fatigue is a heterogeneous symptom associated with lifestyle, infection, exercise, and chronic disease, but its biological links with the gut microbiome remain incompletely defined. This review summarizes clinical and mechanistic evidence connecting gut microbiome alterations with fatigue-related ph…

Development and Content Validity of the Clinical Needs Assessment for Myalgic Encephalomyelitis (CNAME).

To co-produce the Clinical Needs Assessment for Myalgic Encephalomyelitis (CNAME) with patients and clinicians, and to assess its content validity. Guided by the COSMIN guidelines, a draft CNAME was devised from relevant literature and lived experience. It was revised following piloting and cognitiv…