Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review.
To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third-space endoscopy (TSE) procedures for management of benign motility disorders. This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, an…
Development and validation of a rapid 15-minute gastric ultrasound protocol for suspected gastroparesis: a prospective diagnostic accuracy study.
Gastric emptying scintigraphy (GES) is the reference standard for gastroparesis but is limited by time, cost, and accessibility. We aimed to validate a practical 15-minute gastric ultrasonography (GUS) threshold for early assessment of suspected gastroparesis. We conducted a prospective diagnostic a…
Prevalence and burden of functional dyspepsia and "gastroparesis-like" symptoms in a primary care diabetes population.
The prevalence of gastroparesis (GP) and functional dyspepsia (FD) in diabetes remains unknown. Nausea and/or vomiting are now considered cardinal symptoms for GP, defining the "gastroparesis-like symptoms" (GPLS). We aimed to assess the prevalence of GPLS and FD in type 1 (T1D) and type 2 diabetes…
Treatment of Refractory Gastroparesis With Laparoscopic Sleeve Gastrectomy and Pyloroplasty Leading to Symptom Improvement and Increased Gastric Emptying: First Clinical Experience in a Canadian Center.
Laparoscopic sleeve gastrectomy (LSG) and pyloroplasty have been identified as treatment options for gastroparesis refractory to dietary, medical, gastric electrical stimulation, and advanced endoscopic therapies (ie, gastric peroral endoscopic myotomy). This case outlines the management of refracto…
The Gut-Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism-Based Precision Medicine.
Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non-motor…
Gastroparesis Phenotyping: Current Methods and Emerging Opportunities With Magnetic Resonance Imaging.
Gastroparesis is a complex gastrointestinal motility disorder characterized by delayed gastric emptying. Its pathophysiology varies across patients, arising from impaired fundic tone, antral hypomotility, pylorospasm, antropyloroduodenal incoordination, or combinations thereof. Current clinical diag…
PTSD Is Associated With Severity of Upper GI Symptoms in Patients With Gastroparesis.
Posttraumatic stress disorder may contribute to chronic overactivation of the sympathetic nervous system and exacerbate GI symptoms. The purpose of this study was to evaluate the impacts of PTSD on GI symptom severity and psychological functioning in patients with gastroparesis. We conducted a cross…