Incidence of Gastrointestinal Adverse Events and Healthcare Resource Utilization in Patients Using Glucagon-Like Peptide-1 Analogs: A Real-World Study.
Glucagon-like peptide-1 receptor agonists (GLP-1) are widely prescribed for diabetes mellitus (DM) and obesity. Growing concerns about gastrointestinal side effects (GI-AE) prompted this real-world study, to assess the incidence of GI-AEs and the associated healthcare burden in patients on GLP-1
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Rapid Gastric Emptying: Insights from a Large Cohort Study on a Controversial Disorder.
Rapid gastric emptying (RGE) is conventionally defined as ≥ 70% emptying of a standardized solid meal at 1 h using gastric emptying scintigraphy (GES). However, this threshold is not universally adopted, and variability exists in how accelerated gastric emptying is defined…
Third-space endoscopy: Current techniques, clinical applications, and future directions.
Third-space endoscopy refers to a set of endoscopic techniques that allow access to the submucosal space or "third space" between the mucosa and muscularis propria, enabling therapeutic intervention while preserving mucosal integrity. The unifying concept across all third-space endoscopy procedures…
Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: 'Auckland Classification' v1.0.
Chronic gastroduodenal disorders remain challenging to manage, and new diagnostic approaches are needed to better delineate underlying causes and guide therapeutic decisions. Body Surface Gastric Mapping (BSGM) technologies combine high-resolution gastric myoelectrical activity measurements with sym…
Gastric Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection for the Treatment of Refractory Gastroparesis: A Cost-Effectiveness Analysis.
Gastroparesis (GP) is a chronic gastrointestinal motility disorder that imposes a substantial clinical and economic burden. For patients with refractory GP, gastric peroral endoscopic myotomy (G-POEM) and botulinum toxin injection (BTI) are emerging therapies with differing efficacy profiles and pro…
Current Concepts in Perioperative Guidance and Outcomes in Hand Surgery Patients Taking Glucagon-Like Peptide-1 Receptor Agonists.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide and tirzepatide, have rapidly increased in use for diabetes management and weight loss, coinciding with the rising prevalence of obesity and diabetes among patients undergoing hand surgery. Growing perioperative concerns of d…
Safety and efficacy of strictureplasty for primary proximal duodenal Crohn's disease: a retrospective single-center case series.
Primary proximal duodenal Crohn's disease (CD) is a rare entity that can lead to fibrotic strictures and gastric outlet obstruction. Surgical intervention is often required in refractory cases, yet the optimal approach remains debated. This study aimed to evaluate the safety and efficacy of strictur…
MYH11-Related Hereditary Type 2 Visceral Myopathy in a Large Kindred: Diagnostic Odyssey With Milder Clinical Manifestations.
MYH11-related hereditary type 2 visceral myopathy is a rare smooth muscle disorder typically presenting in infancy with severe gastrointestinal and genitourinary dysfunction. We describe a 73-year-old female with lifelong symptoms of gastrointestinal and urinary dysfunction, including chronic consti…