Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review.
To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third-space endoscopy (TSE) procedures for management of benign motility disorders. This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, an…
Development and validation of a rapid 15-minute gastric ultrasound protocol for suspected gastroparesis: a prospective diagnostic accuracy study.
Gastric emptying scintigraphy (GES) is the reference standard for gastroparesis but is limited by time, cost, and accessibility. We aimed to validate a practical 15-minute gastric ultrasonography (GUS) threshold for early assessment of suspected gastroparesis. We conducted a prospective diagnostic a…
Diabetic autonomic neuropathy is a clinically important component of diabetic neuropathy involving the cardiovascular, gastrointestinal, genitourinary, sudomotor, pupillary, and glucose counterregulatory systems. Cardiovascular autonomic neuropathy (CAN) has been extensively studied and is clinicall…
Differential Oral Absorption Pharmacokinetics of Tacrolimus in Simultaneous Kidney-Pancreas Transplant Compared to Kidney Transplant Recipients.
Simultaneous pancreas kidney transplantation (SPK) is a preferred option for type 1 diabetes (T1DM) patients with end-stage renal disease (ESRD). Most transplant centers use kidney transplant (KT) protocols target trough concentrations (C0) to dose tacrolimus in SPK recipients, due to a lack of evid…
[Peripheral Autonomic Neuropathy in α-Synucleinopathy].
Parkinson disease and pure autonomic failure are α-synucleinopathies that lead to peripheral autonomic neuropathy. These autonomic disturbances include well-known symptoms, such as orthostatic hypotension and constipation, and often overlooked symptoms, including supine hypertension and gastro…
This review critically analyses a systematic review with a network meta-analysis (NMA) on the effectiveness of endoscopic interventions for gastroparesis by Eckhardt et al. (Eckhardt D, et al. BJS 2025;112. DOI: 10.1093/bjs/znaf183) is critically analysed in the light of the literature. The results…
PPI-Refractory GERD in systemic sclerosis is driven by distinct esophageal and gastric motility abnormalities.
Gastroesophageal reflux disease (GERD) is highly prevalent in systemic sclerosis (SSc) and frequently persists despite proton pump inhibitor (PPI) therapy. We aimed to characterize the contribution of esophageal and gastric dysmotility to PPI-refractory GERD in SSc. We conducted a single‑cent…
[Characteristics and Treatment of Peripheral Autonomic Neuropathy].
Peripheral autonomic disorders, including autonomic neuropathies, lead to autonomic failure, a condition characterized by reduced autonomic function. The clinical manifestations involve multiple organ systems: in the cardiovascular system, orthostatic hypotension, postprandial hypotension, and supin…