Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review.
To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third-space endoscopy (TSE) procedures for management of benign motility disorders. This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, an…
Development and validation of a rapid 15-minute gastric ultrasound protocol for suspected gastroparesis: a prospective diagnostic accuracy study.
Gastric emptying scintigraphy (GES) is the reference standard for gastroparesis but is limited by time, cost, and accessibility. We aimed to validate a practical 15-minute gastric ultrasonography (GUS) threshold for early assessment of suspected gastroparesis. We conducted a prospective diagnostic a…
Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction.
Gastrointestinal (GI) symptoms are frequent in disorders that involve the autonomic nervous system (ANS) or the enteric neuromuscular apparatus. Although dysfunction may occur anywhere along the alimentary tract, gastric manifestations are often the most clinically visible 'end-organ' expression of…
Comparative Short-term Risk of Severe Gastrointestinal Events Associated With Opioid Type Among Patients Receiving Glucagon-Like Peptide-1 Receptor Agonists.
To compare the risk of motility-related gastrointestinal (GI) events associated with commonly prescribed opioids among adults with type 2 diabetes (T2D) prescribed glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy, a population in whom the GI safety of concomitant opioid use has not been we…
Gastric amyloid pathology and mucosal denervation in ATTRv amyloidosis: insights from patients, mice, and gut microenvironment profiles.
Hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN) frequently presents with gastrointestinal autonomic dysfunction, but its underlying pathology remains unclear. We examined gastric mucosal amyloid deposition and innervation using conventional endoscopic biopsies in ATTRv-PN patients and a h…
PPI-Refractory GERD in systemic sclerosis is driven by distinct esophageal and gastric motility abnormalities.
Gastroesophageal reflux disease (GERD) is highly prevalent in systemic sclerosis (SSc) and frequently persists despite proton pump inhibitor (PPI) therapy. We aimed to characterize the contribution of esophageal and gastric dysmotility to PPI-refractory GERD in SSc. We conducted a single‑cent…
Gastrointestinal manifestations of Parkinson's disease.
Gastrointestinal involvement is common in Parkinson's disease (PD) and symptoms related to gastrointestinal dysfunction may feature prominently, impact on quality of life and compromise nutrition. While all components of the gastrointestinal tract may be involved, drooling, dysphagia and constipatio…