Integrating multi-omics and mendelian randomization identifies therapeutic targets for Lichen Sclerosus: A druggable genome-wide study.
Lichen sclerosus (LS) is a chronic inflammatory skin disease characterized by limited treatment options and an unclear pathogenesis. This study aimed to identify potential therapeutic targets for LS by integrating druggable genome (DG) data with multi-omics and Mendelian randomization (MR). Blood ex…
Male genital lichen sclerosus (MGLSc) is a chronic inflammatory dermatosis that may lead to phimosis, urethral disease, sexual dysfunction and penile squamous cell carcinoma (PeSCC). Although its aetiology remains incompletely understood, clinical and epidemiological observations increasingly suppor…
Navigating Sexual Challenges as a Couple in the Context of Vulvar Lichen Sclerosus: A Reflexive Thematic Analysis Informed by Sexual Script Theory.
Vulvar lichen sclerosus (VLS) is a chronic, inflammatory skin condition that can lead to vulvar itch and pain as well as challenges in sexual relationships. Yet, little research explores how couples coping with VLS navigate sexual challenges. Informed by sexual script theory and the concept of sexua…
Development of an analytical procedure for the characterization of the particulate matter emitted by the braking system.
Brake wear particulate matter (PM) is a relevant source of non-exhaust emissions, but its inorganic characterization remains analytically challenging because of the heterogeneous composition of friction materials and the low concentrations of several target analytes. In this work, a multitechnique a…
When Skin Disease Affects Intimacy: The Ethical Duty for Dermatologists to Screen for Sexual Dysfunction.
Sexual health is central to quality of life; yet, its relationship to dermatologic disease remains insufficiently studied. Skin conditions can directly contribute to sexual dysfunction through pruritus, scarring, pain, and body image distress, and genital involvement is common but often overlooked.…
Disease-mutations perturb proton transfer reactions in respiratory complex I.
Respiratory Complex I powers oxidative phosphorylation by a long-range proton-coupled electron transfer (PCET) reaction, with mutations linked to more than half of all human mitochondrial disorders. Yet, the molecular principles underlying the functional impairment remain difficult to test, as most…