The impact of anxiety on vulvar dermatological diseases: a systematic review.
Vulvar inflammatory dermatoses, including lichen sclerosus, lichen planus, lichen simplex chronicus, and psoriasis, have been shown to impact mental health and quality of life. We aimed to synthesize and evaluate the current literature regarding the association between anxiety and vulvar inflammator…
Integrating multi-omics and mendelian randomization identifies therapeutic targets for Lichen Sclerosus: A druggable genome-wide study.
Lichen sclerosus (LS) is a chronic inflammatory skin disease characterized by limited treatment options and an unclear pathogenesis. This study aimed to identify potential therapeutic targets for LS by integrating druggable genome (DG) data with multi-omics and Mendelian randomization (MR). Blood ex…
Exhalation Delivery System with Fluticasone in Chronic Rhinosinusitis by Eosinophil, Asthma, and Allergy Status.
Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and paranasal sinuses. Comorbid asthma, environmental allergies, and eosinophilia are associated with CRS. Exhalation delivery system with fluticasone (EDS-FLU) is approved for CRS; however, the influence of these features on treatm…
Laser and Light-Based Therapies in Inflammatory Dermatoses: A Systematic Review of Safety, Efficacy, and Adverse Effects to Inform Cosmetic Use.
Laser and light-based therapies are widely used in dermatology, yet patients with inflammatory dermatoses are often excluded from cosmetic procedures due to concerns for disease exacerbation. This systematic review evaluated the safety and efficacy of these modalities to inform their use. A PRISMA-g…
Loneliness in Eating Disorders: Is It Related to Specific Eating Behaviors? A Transdiagnostic Analysis From a Bicentric Italian Study.
Loneliness is the emotional experience arising from the discrepancy between an individual's desired and actual social relationships. Despite a solid rationale for expecting high levels of loneliness in eating disorders (EDs), this construct has been relatively underexplored. The present study aimed…
Behçet's-Like Syndrome Associated With Psoriasis, Lichen Sclerosus and Variant in NF-κB1.
Behçet's disease is a rare multisystem inflammatory disorder characterised by recurrent oral and genital ulceration with systemic involvement. Heterozygous mutations in NF-κB1 have been associated with Behçet's-like presentations. We present a woman with psoriasis, lichen sclerosus,…
Efficacy of nipocalimab in patients with moderate-to-severe ocular symptoms of generalized myasthenia gravis in the phase 3 Vivacity-MG3 study.
In the global Vivacity-MG3 study, nipocalimab (30-mg/kg loading dose; 15-mg/kg every-2-weeks) demonstrated sustained disease control versus placebo plus standard-of-care for generalized myasthenia gravis (gMG); this post-hoc analysis evaluated nipocalimab efficacy for participants with moderate-to-s…