Clinical spectrum of penile intraepithelial neoplasia in a sexual health service: a retrospective case series.
Penile intraepithelial neoplasia (PeIN) is an uncommon precursor to invasive penile squamous cell carcinoma (SCC). Its heterogeneous appearance may overlap with inflammatory penile dermatoses, genital warts, or infection, potentially delaying diagnosis. We aimed to characterise the clinical spectrum…
Reassessing the age distribution of vulvar lichen sclerosus: A retrospective cohort study.
Vulvar lichen sclerosus (vLS) is widely reported to affect postmenopausal women and premenarchal girls; however, literature is limited and largely based on histopathologic diagnosis, despite the fact that diagnosis is primarily clinical. We hypothesize that the age distribution of women diagnosed wi…
Vulvar Lichen Sclerosus as a Risk Factor for Birth-related Perineal Tear.
Vulvar lichen sclerosus is a chronic inflammatory skin disease that predominantly affects the anogenital region. While typically observed in postmenopausal women, it may also occur in women of reproductive age. The condition is diagnosed in approximately 1.7% of women; however, the actual prevalence…
MicroRNA expression in vulvar lichen sclerosus keratinocytes and fibroblasts: further evidence and possible pathogenetic implications from an observational study.
It seems established that genetic and epigenetic determinants drive the multifactorial pathogenic processes in vulvar lichen sclerosus (VLS). Aberrant expression of microRNAs (miRNAs) has been observed in a few studies suggesting their potential involvement. Our aim was to assess the expression of m…
[Vulvar intraepithelial neoplasia and vulvar cancer].
Vulvar intraepithelial neoplasia (VIN) is divided into human papillomavirus (HPV)-associated lesions (undifferentiated VIN, high-grade squamous intraepithelial lesion) and HPV-independent VIN (predominantly differentiated VIN). This new WHO classification is essential for the diagnostics, treatment…
The impact of anxiety on vulvar dermatological diseases: a systematic review.
Vulvar inflammatory dermatoses, including lichen sclerosus, lichen planus, lichen simplex chronicus, and psoriasis, have been shown to impact mental health and quality of life. We aimed to synthesize and evaluate the current literature regarding the association between anxiety and vulvar inflammator…
Histopathologic Comparison Between Morphea, Lichen Sclerosus, and Systemic Sclerosis: A Prospective Cross-Sectional Observational Study From a Tertiary Care Hospital.
Morphea, lichen sclerosus (LS), and systemic sclerosis (SSc) are chronic sclerosing dermatoses with overlapping clinical features that can complicate diagnosis. Although histopathology is essential for differentiation, comparative studies on their histopathologic characteristics remain limited. This…