Reversing zinc dyshomeostasis and oxidative stress: A metallothionein 1-activating MXene/Zn2+ triple-action nanotherapeutic strategy for chronic non-bacterial prostatitis.
Chronic non-bacterial prostatitis (CNP), a prevalent and debilitating urological disorder affecting 8.4% of men aged 15-60 years, presents significant clinical challenges due to the paucity of targeted therapies and poor patient adherence. To address this unmet medical need, we developed an innovati…
Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
No difference in anxiety symptoms between women with unilateral and bilateral ovarian endometriosis: a prospective cross-sectional study.
This study aimed to investigate whether women with unilateral and bilateral OMA differ in anxiety symptoms, and secondarily in depressive symptoms and sexual dysfunction symptoms, and to evaluate the independent contribution of chronic pelvic pain to psychological outcomes. This study, a prospective…
p53-mediated epigenetic regulation in the pathogenesis of endometriosis.
Endometriosis (EMs) is a common gynecological disorder affecting reproductive‑aged women, characterized by ectopic endometrial growth and chronic pelvic pain that severely impairs quality of life. Although its pathogenesis remains incompletely understood, accumulating evidence indicates that…
Body image concerns in individuals with endometriosis and chronic pelvic pain conditions: A systematic review and meta-analysis.
Body image disturbance is a commonly experienced psychological impact of endometriosis and other chronic pelvic pain (CPP) conditions (e.g., vulvodynia). This systematic review and meta-analysis of quantitative literature aimed to describe the prevalence of body image concerns in endometriosis and o…
Three- and Four-Dimensional Pelvic Floor Ultrasound in Chronic Pelvic Pain: Evidence, Technical Considerations, and a Proposed Framework.
Chronic pelvic pain (CPP) is a heterogeneous condition in which visceral, musculoskeletal, neuropathic, and pain-processing contributors often overlap. Pelvic floor ultrasound can depict morphology and movement, but its CPP-specific evidence base remains limited. This targeted narrative review summa…
Prostate lymphoma uncovered during urological encounters: Diagnostic challenges and clinical outcomes in a case series with systematic review of the literature.
Prostatic lymphoma is a rare malignancy that can clinically resemble benign prostatic hyperplasia (BPH) or adenocarcinoma, often delaying diagnosis. Primary prostatic lymphoma (PPL) comprises <0.1% of prostate tumors and non-Hodgkin lymphomas, whereas secondary involvement occurs more commonly in sy…
Metastatic High-Grade Endometrial Stromal Sarcoma With ZC3H7B::BCOR Fusion in Pleural Fluid: A Case Report.
Pleural fluid involvement by high-grade endometrial stromal sarcoma (HG-ESS) is exceedingly rare, with only one previously reported case. We report a case of ZC3H7B::BCOR fusion-positive HG-ESS metastatic to the pleural fluid in a 32-year-old female who presented with pelvic pain and a large uterine…