Reversing zinc dyshomeostasis and oxidative stress: A metallothionein 1-activating MXene/Zn2+ triple-action nanotherapeutic strategy for chronic non-bacterial prostatitis.
Chronic non-bacterial prostatitis (CNP), a prevalent and debilitating urological disorder affecting 8.4% of men aged 15-60 years, presents significant clinical challenges due to the paucity of targeted therapies and poor patient adherence. To address this unmet medical need, we developed an innovati…
Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial.
Vestibulodynia (VBD) is a common chronic pelvic pain condition with heterogeneous clinical presentation, including subtypes distinguished by the presence (VBD-central; VBD-c) or absence (VBD-peripheral; VBD-p) of comorbid pain conditions. Despite frequent prescribing of topical therapies such as lid…
Nanoparticle-based therapeutic platforms for inflammatory disorders of the urinary system: Engineering local delivery, biointerface regulation, and smart responsive therapy.
Inflammatory diseases of the urinary system, including urinary tract infection (UTI), catheter-associated urinary tract infection (CAUTI), interstitial cystitis/bladder pain syndrome (IC/BPS), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), are associated with high recurrence, comple…
Uterine angiomatosis as an unexpected cause of refractory pelvic pain and heavy menstrual bleeding: a case report and literature review.
Angiomatosis is a rare benign vascular lesion characterised by diffuse, haphazard proliferation of blood vessels, most commonly within adipose and fibrous tissue. This report describes the case of a patient in her early 30s who presented with refractory menorrhagia and pelvic pain. Following total l…
Prediction of chronic pelvic pain after adenomyosis surgery: an observational comparative study.
Chronic pelvic pain (CPP) remains a common and clinically challenging outcome after uterus-preserving surgery for adenomyosis. Identifying patients at higher risk of postoperative CPP may facilitate individualised postoperative management. The clinical data of 150 patients with adenomyosis admitted…
Second trimester adnexal torsion of a large ovarian mature teratoma: Diagnostic value of whirlpool sign.
Adnexal torsion is a gynecological emergency and an important cause of acute pelvic pain, occurring most frequently in women of reproductive age. In pregnancy, torsion is classically associated with ovarian stimulation and small-to-medium sized mobile adnexal masses. We report the case of a 35-year-…
Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
No difference in anxiety symptoms between women with unilateral and bilateral ovarian endometriosis: a prospective cross-sectional study.
This study aimed to investigate whether women with unilateral and bilateral OMA differ in anxiety symptoms, and secondarily in depressive symptoms and sexual dysfunction symptoms, and to evaluate the independent contribution of chronic pelvic pain to psychological outcomes. This study, a prospective…