Phenotypes of Chronic Overlapping Pain Multimorbidity in Rheumatology: A Population-Based Claims Study.
This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008-2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 p…
Lesion-centric reprogramming: hydrogel-enabled photothermal reset of endometriosis pain.
Endometriosis-associated pelvic pain represents a prototypical failure of systemic therapy for a locally organized, neuroinflammatory disease. Persistent pain arises from the convergence of estrogen-driven lesion survival, chronic inflammation, fibrosis, and aberrant neuroangiogenesis, leading to su…
Imaging and Pitfalls of Early Postpartum Complications after Vaginal and Cesarean Section.
The postpartum period is associated with a wide spectrum of potential complications that may lead to significant maternal morbidity and mortality if not promptly diagnosed and treated. Clinical presentation is frequently nonspecific - including symptoms such as pelvic pain, fever, and vaginal bleedi…
Urine Proteins Stratify Patient Symptom Severity Phenotypes in UCPPS: A MAPP Research Network Study.
To define a set of urinary proteins that correlate with symptom severity in urologic chronic pelvic pain syndrome (UCPPS) and validate a putative molecular test for symptom severity based on quantitatively varying urinary proteins. Quantitative urinary proteomic analysis of 81 UCPPS subjects was per…
Prevalence, seasonal patterns, and microbial co-occurrence of selected genital tract microorganisms in women attending a gynecological counseling service in Southern Italy.
Sexually transmitted infections (STIs) represent a major global public health problem due to their potential to cause serious complications such as infertility, chronic pelvic pain, and increased susceptibility to HIV. Young adults, and especially women of reproductive age, are particularly vulnerab…
ESPriT1: The effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for managing chronic pelvic pain in women: a randomised controlled feasibility trial.
Endometriosis is a chronic pain condition that affects >190 million people worldwide. It is recommended in clinical guidelines to remove the most common type of endometriosis, 'superficial peritoneal endometriosis' (SPE), if it is diagnosed at laparoscopy (keyhole surgery). However, the evidence to…
Sciatica beyond the spine: a prospective study on laparoscopic neurolysis of pelvic sciatic and sacral nerves demonstrating long-term improvements in pain, function, mood, and bladder symptoms (VAS, SF-36, PHQ-9, OAB-V8).
Intrapelvic entrapment of the sciatic and sacral nerve roots can cause chronic pelvic pain, sciatica, and symptoms such as dysmenorrhea, dyspareunia, dyschezia, dysuria, vulvodynia, coccygodynia, and pudendal neuralgia. Conventional spine-focused approaches often overlook this cause. This study asse…
Intracardiac migration of a left renal vein stent after endovascular treatment of nutcracker-associated pelvic congestion syndrome: a case report.
Left renal vein (LRV) stenting is used in selected patients with symptomatic Nutcracker syndrome (NCS). Stent migration is uncommon but may be serious, particularly in interventions performed primarily for symptom relief. We report intracardiac migration after combined treatment of NCS-associated pe…