A cardiac debut: Myocarditis revealing seronegative primary Sjögren's syndrome in a young woman-A case report.
Myocarditis as the inaugural manifestation of primary Sjögren's syndrome is exceptionally rare, and its occurrence in a seronegative patient without prominent sicca features represents a particularly challenging diagnostic scenario. We report a 20-year-old woman presenting with chest pain and i…
Osteoporosis prediction in primary Sjögren's syndrome: development and external validation of a machine-learning comparison model.
Osteoporosis and fragility fractures are clinically important complications of primary Sjögren's syndrome (pSS) that may accelerate functional decline and excess mortality. In practice, osteoporosis risk is often assessed using general-population tools that do not incorporate disease activity,…
Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank.
Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited. To evaluate the association between self-reported oral health issues by questionnaire-defined as the presence of painful or bleeding gu…
Medication adherence is associated with the necessity-concern differential in newly diagnosed primary Sjögren disease: a prospective observational cohort study.
The objectives of this study were, firstly, to assess medication adherence and, secondly, to evaluate the relationships between medication adherence and symptoms, disease activity, and patient-reported outcomes in patients with newly diagnosed primary Sjögren disease (pSjD). In this prospective…
Sjögren's disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma.
Ninety-five percent of patients with the Sjögren's disease (SjD) experience hyposalivation, which studies suggest is not strongly associated with salivary gland (SG) lymphocytic infiltration. Resident CD8+ T cells have recently been associated with SG pathology in SjD. We investigated the relat…
Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study.
Prior studies suggested that maternal systemic autoimmune rheumatic diseases (SARDs) may increase the risk of mental disorders (MDs) in offspring. However, evidence is limited by heterogeneous definitions of autoimmune rheumatic diseases, focusing on specific MDs and scarce data from Asian populatio…