A cardiac debut: Myocarditis revealing seronegative primary Sjögren's syndrome in a young woman-A case report.
Myocarditis as the inaugural manifestation of primary Sjögren's syndrome is exceptionally rare, and its occurrence in a seronegative patient without prominent sicca features represents a particularly challenging diagnostic scenario. We report a 20-year-old woman presenting with chest pain and i…
SLC4A9 deficiency is involved in Sjögren's syndrome and enamel defects through RPS27-triggered ribosomal stress.
Xerostomia, a salivary gland disorder affecting up to 30% of adults, compromises oral homeostasis by reducing salivary flow and buffering capacity. Amelogenesis imperfecta is a hereditary condition characterized by defective enamel formation and mineralization, with a prevalence ranging from 1 in 70…
Exploring Factors Associated With Psychological Resilience in Sjögren's Disease.
This study aimed to examine the factors associated with psychological resilience in Sjögren's disease. This cross-sectional study included 83 patients (F/M: 79/4). Hyposalivation was observed in 41%, while Schirmer's test positivity was observed in 84.3% of patients. Scores of the Brief Resilie…
Translational PBPK Modeling and Exposure-Response Analysis of AT-RvD1 for Treating Sjögren's Disease.
Sjögren's disease (SD) is an autoimmune condition characterized by chronic inflammation and impaired secretory function of the salivary glands (SG). The proresolving lipid mediator AT-RvD1 restores SG function in SD-like mice; however, its tissue pharmacokinetics, exposure-response relationship…
Depression is a major and under-recognized comorbidity in Sjögren's disease, contributing to disease burden and impaired quality of life. This narrative review summarizes current evidence regarding the prevalence, pathophysiological mechanisms, clinical impact, assessment, and treatment of depr…
Correlation between serum IgG levels and labial gland pathological grading in patients with suspected Sjögren's syndrome: a cross-sectional analysis.
To investigate the clinical association between serum immunoglobulin G (IgG) levels and labial gland pathological grading in patients with suspected Sjögren's syndrome (SjD). This retrospective cross-sectional study included hospitalized patients with suspected SjD who underwent labial gland bi…
IFN-γ-Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease.
Sjögren's disease (SD) is a chronic systemic autoimmune disorder that can affect multiple organ systems. Interstitial lung disease (ILD) is a clinically significant pulmonary manifestation of SD and is associated with impaired quality of life and increased mortality. Interferon-γ (IFN-&#x…