A cardiac debut: Myocarditis revealing seronegative primary Sjögren's syndrome in a young woman-A case report.
Myocarditis as the inaugural manifestation of primary Sjögren's syndrome is exceptionally rare, and its occurrence in a seronegative patient without prominent sicca features represents a particularly challenging diagnostic scenario. We report a 20-year-old woman presenting with chest pain and i…
Extra-articular rheumatoid arthritis: example of RA-associated interstitial lung disease.
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. However, extra-articular manifestations are common and can be serious. These include cutaneous rheumatoid nodules, Sjögren's disease, vasculitis, Felty syndrome, and pulmonary manifestations such as in…
Gradually Enlarging Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome.
A 65-year-old woman with primary Sjögren's syndrome without a history of immunosuppressive therapy presented with progressively enlarging pulmonary nodules showing calcification and cystic changes, mimicking malignancy. Histological examination confirmed AL λ-type nodular pulmonary amyloi…
Loss of epitranscriptomic mitochondrial RNA surveillance drives epithelial type I interferon and inflammation in autoimmunity.
Chronic interferon (IFN) activation is a hallmark of autoimmune diseases such as systemic lupus erythematosus and Sjögren's disease (SjD), where epithelial cells are key contributors. Although viral and retroelement triggers have been proposed as triggers, direct evidence in patient tissues is…
AQP1 Corrects Acinar Cells' Secretion Deficits in Sjögren's Disease.
Sjögren's disease (SjD) is a systemic autoimmune disease characterized by dry mouth, dry eyes, and profound fatigue. Preclinical studies suggest that AQP1 gene expression in salivary glands corrects salivary hypofunction in preclinical and clinical studies of radiation-induced xerostomia and im…
Sphingolipid Metabolism in Oral Diseases: Pathogenic Mechanisms, Biomarkers, and Therapeutic Opportunities.
Sphingolipids, essential structural components of biological membranes, form a framework that maintains their stability and fluidity. In addition to their structural function, these lipids and their metabolites participate in regulating multiple cellular processes, including proliferation, different…
Integrin α7-Driven Senescence-Associated Follicular Helper T Cell Adhesion Induces Tertiary Lymphoid Structures in Nishiura Mice.
Senescence-associated follicular helper T (SA-Tfh) cells contribute to tertiary lymphoid structure (TLS) formation in autoimmune diseases, yet the mechanisms guiding their localization to glandular niches remain unclear. In the Nishiura (NI) Sjögren's disease (SjD) mouse model, we demonstrated…
Autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk.
Patients with autoimmune diseases (AIDs) are at an increased risk of developing cancer; however, the immunometabolic programs that shape this comorbidity remain incompletely defined. We integrated targeted serum metabolomics with multiplex profiling of cytokines, chemokines, and immune checkpoint pr…