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Post-Exertional Malaise

52 papers & discussions

PEM is the worsening of symptoms following physical or mental exertion, and is the hallmark feature of ME/CFS.

Symptom flare after exertionSevere fatigueCognitive worseningPain increaseSleep disruptionFlu-like symptoms

Research

52
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PubMed

High Free-Volume Imidazole-Based Ionomers for High-Temperature Proton Exchange Membrane Fuel Cells.

Excessive swelling and mechanical degradation of high-temperature proton exchange membranes (HT-PEMs) compromise interfacial stability and long-term durability, although high phosphoric acid (PA) doping is required for sufficient proton conductivity. Addressing this trade-off requires ionomers capab…

pem
PubMed

Mercaptoimidazole-Engineered Microenvironment Enables Durable CO2 Electroreduction in a Zero-Gap PEM Electrolyzer.

CO2 conversion in proton exchange membrane (PEM) electrolysis systems offers a sustainable pathway for chemical production by eliminating carbonate formation; however, it faces a trade-off between suppressing the hydrogen evolution reaction and preventing salt precipitation. Here, we resolve this pa…

mspem
PubMed

Neuroimmune Crosstalk: Peripheral Nervous System Disorders After Immune Checkpoint Inhibitors.

This study aimed to identify the frequency and types of peripheral nervous system involvement, associated clinical features, treatment options, and prognosis in patients receiving immune checkpoint inhibitors (ICIs) for the treatment of malignancy. This is a retrospective cross-sectional study. We i…

pemmyositis
PubMed

A nomogram for risk stratification of protein-energy malnutrition in pediatric cancer patients: development and internal validation.

To develop and internally validate a nomogram for predicting the risk of protein-energy malnutrition (PEM) in pediatric cancer patients and to evaluate its clinical utility. A total of 375 pediatric cancer patients admitted to a tertiary hospital in Xinjiang (January-May 2025) were enrolled. Nutriti…

pem
PubMed

Constructing Heterogeneous Metal Nodes in Metal-Organic Framework Lamellar Membranes for High Proton Conduction in Fuel Cells.

Precisely defining proton transport channels and regulating the chemical microenvironment of proton carriers are critical for high-performance proton exchange membranes (PEMs). Beyond optimizing carrier type and density, modulation of electron density distribution offers an underexplored route to en…

mslichen sclerosuspem
PubMed

[Transdisciplinary Expert Statement: care guide for people severely affected by ME/CFS in home-based care].

Many of those affected by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have significant care needs. However, post-exertional malaise, the defining feature of ME/CFS, means that even minor physical, orthostatic, cognitive, or sensory stressors can trigger a disproportionate worsen…

me cfschronic fatigueantiphospholipid syndromepem
PubMed

Novel activity and participation scales for children, adolescents, and young adults with postacute infection and vaccination syndromes and/or ME/CFS.

Children, adolescents, and young adults (CYP) with postacute infection and vaccination syndromes (PAIVS), and/or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), experience profound loss in activity and participation. We introduce and psychometrically validate two new brief, age-adapted,…

me cfschronic fatiguecervical instabilitylichen sclerosus
PubMed

Clinical and radiological outcomes of ustekinumab in pediatric perianal Crohn's disease: a multicenter retrospective study from the Pediatric IBD Porto Group of ESPGHAN.

Perianal Crohn's disease (pCD) is a severe pediatric phenotype with high morbidity. Although antitumor necrosis factor (TNF) agents are first-line therapy, remission is not achieved in a subset of patients. We aimed to evaluate clinical and radiological outcomes of ustekinumab (UST) in pediatric pat…

crohnspem

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