Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo a…
Partial Amorphization of Proton-Conducting Perovskites Triggers Interfacial Water Optimization to Boost Proton Transfer Kinetics for PEM Electrolysis.
Modulating the interfacial water structure at the catalyst-electrolyte interface and optimizing the hydrogen adsorption/desorption kinetics of ruthenium-based electrocatalysts are essential for hydrogen evolution reaction (HER), yet these remain significant challenges. Herein, we propose a hybrid ca…
Participation of Children With Developmental Language Disorders in Educational Settings-Parents' Perspectives on Patterns, Environmental Influences and Support Strategies.
Participation in educational settings is essential for children's development, learning and well-being. Although access to (pre)school is a fundamental right, participation often depends on children's language abilities. Developmental language disorder (DLD) is among the most common childhood condit…
Autoimmune Disease Risk With GLP-1RA, DPP-4i, and SGLT2i Treatment in Patients With Diabetes.
Dipeptidyl peptidase-4 inhibitors (DPP-4i), glucagon-like peptide-1 receptor agonists (GLP-1RA), and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are widely used for type 2 diabetes, yet their comparative immunologic safety is uncertain. To address this gap, we evaluated autoimmune disease inc…
Differences in diagnostic coding in long COVID: sociodemographic and symptom interference factors.
We aimed to test associations of participant-reported Long COVID symptom interference with life activities with Long COVID symptoms, presence of U09.9 Long COVID diagnosis code, demographics, and clinical factors. In a subgroup, we documented coding related to Long COVID and post-exertional malaise…
Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.
Cholangiocarcinoma (CCA) is a common and highly refractory malignancy; however, biomarkers and therapeutic targets associated with its progression remain incompletely understood. Crotonylation is an emerging lysine acylation modification that has been implicated in multiple diseases. In this study,…
A phase-equilibrium outranking method with hysteresis-banded thresholds for robust multi-criteria decision making: PEOM.
Real-world decisions often combine non-compensatory "must-meet" constraints with compensatory trade-offs. Classical Multi-Criteria Decision Making (MCDM) methods (e.g., TOPSIS, VIKOR, PROMETHEE) are mainly compensatory and may rank alternatives highly even when a critical requirement fails. This pap…
Mechanism-Guided Design Strategies for Stabilizing Ruthenium Oxide Anodes in Proton Exchange Membrane Water Electrolysis.
Proton exchange membrane water electrolysis (PEMWE) is a leading route to low-carbon hydrogen, yet its anodic oxygen evolution reaction (OER) remains constrained by the scarcity and instability of noble-metal catalysts under strongly acidic, high-current operation. Ruthenium oxides are attractive al…