Cost-effectiveness of perioperative pembrolizumab plus enfortumab vedotin for cisplatin-ineligible or cisplatin-declining patients with muscle-invasive bladder cancer in the United States.
In the KEYNOTE 905/EV 303 study, perioperative enfortumab vedotin plus pembrolizumab (EV+Pem) improved event-free survival (EFS), overall survival (OS), and pathological complete response in a predominantly cisplatin-ineligible muscle-invasive bladder cancer (MIBC) population, compared with surgery…
Curative-Intent Pancreatectomy for Pancreatic Metastasis From Renal Cell Carcinoma 30 Years After Nephrectomy Following Lenvatinib Plus Pembrolizumab Therapy: A Case Report.
Renal cell carcinoma (RCC) is the most common primary site of pancreatic metastases, and complete resection confers a favorable prognosis. Lenvatinib plus pembrolizumab (LEN + PEM) is standard first-line therapy for advanced RCC; however, induction therapy before resection of pancreati…
Autonomy in Fellowship Training and Its Influence on Self-Reported Self-Efficacy in Pediatric Emergency Medicine.
This study examined the relationship between autonomy during pediatric emergency medicine (PEM) fellowship and self-efficacy in 6 Accreditation Council for Graduate Medical Education-defined entrustable professional activities (EPAs). We hypothesized that experiencing greater autonomy during fellows…
Long COVID in Primary Care: A Practical Approach to Evaluation and Management.
Long COVID is a multi-system, heterogeneous condition that manifests as new or worsened symptoms lasting at least 3 months following acute SARS-CoV-2 infection, often despite normal results on routine diagnostic testing. Common manifestations include fatigue, post-exertional malaise, cognitive impai…
Experimental study on micro-hole drilling in titanium felt using an ultrafast laser.
Titanium felt is a three-dimensional network porous metallic material characterized by outstanding electrical conductivity, corrosion resistance, and mass transport properties. Consequently, it has found critical applications in fields such as proton exchange membrane (PEM) water electrolysis for hy…
Benzylbiphenyl-regulated poly(aromatic ethylimidazole)s toward high-performance high temperature proton exchange membranes in fuel cells.
The development of high temperature proton exchange membranes (HT-PEMs) with simultaneously enhanced proton transport and mechanical robustness remains a major challenge for HT-PEM fuel cells. Herein, we report a molecular backbone engineering strategy based on the incorporation of 4-benzylbiphenyl…
Vacancy-Associated La-Ir Pairs Enable Water-Derived Oxygen-Hydroxyl Coupling for Durable Low-Ir PEM Water Electrolysis.
Developing highly stable, low-iridium catalysts is critical for acidic oxygen evolution, but is limited by structural degradation driven by acid corrosion and voltage polarization. Herein, we report an iridium and lanthanum co-doped manganese-cobalt spinel catalyst, Ir,La-MCOδ, featuring octah…
Breaking the Activity-Stability Trade-Off of RuO2-Based Electrocatalysts for Proton Exchange Membrane Water Electrolyzer: Modulation Strategies and Mechanism Elucidation.
Proton exchange membrane water electrolyzer (PEMWE) is a pivotal technology for renewable green hydrogen production, yet its large-scale deployment is limited by expensive and rare Ir-based oxygen evolution reaction (OER) electrocatalysts. RuO2 emerges as a promising Ir-free alternative attributed t…