Melatonin Effects on PI3K/Akt Pathway and Cognitive Function in Hypoxic Rat Hippocampal Neurons.
This study aims to investigate whether melatonin improves cognitive dysfunction in rats, induced by intermittent hypoxia, by modulating the PI3K/Akt signaling pathway, using an intermittent hypoxia animal model. Sixty-four male Wistar rats were randomly assigned to the following groups: normoxic con…
Cannabinoids for Neuropathic Pain: A Pharmacological Review of Mechanisms, Clinical Translation, and Future Directions.
Neuropathic pain (NP) continues to be a significant clinical issue because the existing treatment modalities have very low efficacy and tolerability. An increasing body of mechanistic and translational data is identifying the endocannabinoid system (ECS) as a key regulator of nociceptive transmissio…
Post-stroke rehabilitation in inflammatory rheumatic diseases: outcome measures, digital tools, and patient education perspectives.
Inflammatory rheumatic diseases (IRDs) represent a significant risk factor for cerebrovascular events, independent of traditional cardiovascular risk factors. The elevated risk of stroke in individuals with IRDs arises from chronic systemic inflammation, endothelial dysfunction, accelerated atherosc…
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Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.
Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID. This…
Post-hospitalized Health Conditions of Covid-19 patients: A Cross-sectional study in Bangladesh.
The objective of this research is to examine comorbidity status of hospitalized Covid-19 patients and its association with post-Covid-19 health complications. Data were collected from 1207 Covid-19 patients who were hospitalized at Dhaka Medical College Hospital (DMCH), Bangladesh from May 2020 to A…
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).
Low-dose naltrexone (LDN) has been used off-label for fibromyalgia syndrome (FMS) for over a decade, supported by small crossover trials. The INNOVA study evaluated the safety and efficacy of LDN 4.5 mg versus placebo on pain intensity over 12 months in women with FMS. In total, 98 wom…
Post-COVID paediatric dysautonomia: never the heart, always the brain-myth or maxim?
Paediatric dysautonomia has become increasingly recognised in children and adolescents, particularly in the post-COVID era. Affected patients commonly present with dizziness, palpitations, exercise intolerance, fatigue, and syncope, although reported prevalence varies widely because of evolving defi…
Impairment of Executive Functions in Premenstrual Syndrome: State or Trait?
The aim of this study was to explore whether cognitive impairments in women with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are phase-dependent or persist across the menstrual cycle. Furthermore, we investigated whether such deficits are limited to working memory (WM) or…