Does maladaptive microvascular flow redistribution cause tissue hypoxia in fibromyalgia?
Fibromyalgia is a chronic pain syndrome characterized by widespread pain, fatigue, and cognitive complaints often described by patients as "brain fog". In the absence of specific physiological, laboratory, or imaging markers, diagnosis remains clinical. Despite extensive investigation, its underlyin…
Pitcher's disease: A case of brain fog, arm weakness, numbness, and tingling.
Thoracic outlet syndrome (TOS) is a rare condition caused by compression of the lower trunk of the brachial plexus and/or subclavian vessels. This case report describes the presentation of a 56-year-old right-handed baseball pitcher who presented with 1 year of right arm pain, finger tingling, heavi…
Symptom burden is associated with health-related quality of life in symptomatic adults with primary sclerosing cholangitis.
The Primary Sclerosing Cholangitis Symptom Assessment Project (PSC-SAP) is a research initiative aimed at developing regulatory-grade PSC-specific symptom measures. During the initial screening phase for PSC-SAP, patient-reported symptom data were collected from a cohort of symptomatic adults. The c…
Central sensitization in long COVID: Associations with autonomic symptom burden, cerebral hypoperfusion, and neuroinflammation.
The mechanisms driving the broad spectrum of Long COVID symptoms-such as fatigue, brain fog, pain, and dysautonomia-remain uncertain. This study investigated central sensitization (CS) as a potential contributor to symptom burden in patients with Long COVID. We aimed to examine its association with…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
dysautonomiasarcoidosissmall fiber neuropathybrain fog
Menopause and Brain Health: Neurobiological Changes, Cognitive Implications, and the Role of Estrogen.
The menopausal transition is characterized by significant hormonal fluctuations, culminating in a decline in estrogen levels. This decline impacts synaptic plasticity, neurotransmitter regulation, the blood brain barrier, cerebral blood flow, and metabolism, leading to cognitive symptoms often descr…
Shadows of infection: Post-coronavirus disease condition and outcome patterns in patients receiving dialysis and kidney transplant recipients.
Post-coronavirus disease 2019 (COVID-19) condition describes a constellation of persistent or fluctuating symptoms and organ dysfunction following severe acute respiratory syndrome coronavirus 2 infection. Patients with end-stage kidney disease (ESKD) on dialysis and kidney transplant recipients (KT…