Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.
Studies have reported inconsistent findings regarding the potential effects of polycystic ovary syndrome (PCOS) on neurocognitive function. This study aimed to investigate whether cognitive function, particularly spatial learning and memory, and hippocampal tissue are impaired in middle-aged rats wi…
Hibiscus sabdariffa protects against fibromyalgia by modulating the neuroinflammation-oxidative stress-microRNA axis.
Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain, fatigue, cognitive dysfunction and neuropsychiatric disturbances, associated with dysregulated oxidative stress and neuroinflammation. Emerging evidence suggests that microRNAs guiding these pathways, including miR-145-5p and…
Gait speed and neurocognitive disorders: a comprehensive systematic review and meta-analysis.
Gait reflects cognitive function and may serve as a window into cognitive health. This study investigates the relationship between gait speed (GS) and the onset of cognitive impairments. A systematic review and meta-analysis of cohort and longitudinal studies from PubMed, Scopus, and Web of Science…
Incidence and Associated Factors for Chronic Pain After ICU Discharge: A Prospective Study.
Survivors of critical illness are at high risk for developing chronic pain. However, evidence regarding new-onset chronic pain in this specific population remains limited in China. This study aimed to investigate the incidence of chronic pain among Chinese intensive care unit (ICU) survivors at 3&#x…
Associations between subjective cognitive difficulties, cognitive test performance, psychiatric symptoms, and quality of life in pediatric long COVID.
Objective: This retrospective study examined the associations between subjective cognitive difficulties, performance scores on standardized cognitive tests, and quality of life (QoL) among pediatric patients with long COVID. Method: This study included 82 pediatric patients with long COVID referred…
Opioid use, disability, and patient-reported cognitive impairment in migraine: Multi-country results from the Chronic Migraine Epidemiology and Outcomes-International Study.
To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. Opioids are not recommended for migraine treatment because of efficacy and safety limitations. This was a post hoc analysis of CaMEO-I, an i…
Long COVID in Primary Care: A Practical Approach to Evaluation and Management.
Long COVID is a multi-system, heterogeneous condition that manifests as new or worsened symptoms lasting at least 3 months following acute SARS-CoV-2 infection, often despite normal results on routine diagnostic testing. Common manifestations include fatigue, post-exertional malaise, cognitive impai…