White matter microstructural abnormalities in neurological poste-acute sequelae of coronavirus disease: Imaging signatures consistent with persistent neuroinflammation.
Essential workers, many of whom were infected with coronavirus disease (COVID-19) at work before vaccination, developed Neurological Post-Acute Sequelae of COVID-19 (N-PASC) at high rates. To characterize white matter abnormalities associated with N-PASC and to examine correlates of symptomatology,…
Clinical Symptoms of Jugular Venous Outflow Obstruction and Their Modification After Targeted Surgical Treatment.
Cerebral venous outflow disorders (CVD) are conditions characterized by impairment of cerebral venous drainage. Associated symptoms have been poorly defined, as no standardized diagnostic criteria exist for this class of conditions; most studies to date have attempted to report on symptoms solely ba…
Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and…
A mixed-methods study comparing clinical and patient-reported perspectives on long COVID: insights from electronic health records and narrative journal entries.
Many studies of Long COVID have used a variety of clinical and self-reported data to characterize this condition. Previous research has shown the many ways in which these two types of data sources can differ. Our study aims to expand on previous research by exploring descriptions of Long COVID using…
7 Tesla MRI links poorer cognitive function to higher perivascular space burden in neuroPASC.
Post-acute sequalae of SARS-CoV-2 (PASC) are associated with persistent neurological symptoms (neuroPASC). Perivascular spaces (PVS) in the brain may enlarge in the context of inflammation and vascular dysfunction, reflecting impaired glymphatic clearance, and have been linked to cognitive decline.…
Chronic fatigue syndrome in nursing practice: a concept analysis.
Nurses are essential in chronic fatigue syndrome (CFS) management, serving as care coordinators and patient advocates, but currently lack a unified guiding framework. CFS affects about 0.89% of the global population based on CDC-1994 criteria, with higher prevalence in women. Since its initial defin…
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has sparked a global pandemic with extensive spread, posing a severe threat to public health due to its high mortality rate in severe cases. The continuous emergence of variants with enhanced immune evasion capabilities, coupled with the p…