Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Burden among participants with central disorders of hypersomnolence in six European countries.
Narcolepsy types 1 and 2 (NT1/NT2) and idiopathic hypersomnia (IH) are central disorders of hypersomnolence (CDHs) that significantly impact patients' quality of life (QoL). We investigated the recent medication use, comorbidities, and clinical burden among participants with CDHs from six European c…
PFO assessment and closure for the general physician.
A quarter of adults have a persistent (patent) foramen ovale (PFO). Right-to-left shunting through a PFO can facilitate paradoxical thromboembolism, cryptogenic stroke, paradoxical gas embolism, decompression sickness, arterial hypoxaemia and migraine with aura. Atrial septal defects and pulmonary s…
Migraine in women undergoing fertility treatment: A prospective study.
To determine if there is increased headache burden and disability among women with and without migraine during an in vitro fertilization (IVF) cycle. Migraine and infertility commonly impact women of childbearing age. Estradiol fluctuations influence migraine, yet the impact of exogenous estrog…
Bridging Objective and Subjective Data: A Comprehensive Architecture for Wearable Health Research.
This study presents a secure, end-to-end architecture for multimodal health data collection and integration using a multisensor wearable device (Empatica EmbracePlus) and a mobile health application (FoTiP). The system captures continuous, objective data as well as subjective data, by integrating th…
Pharmacological and transcutaneous auricular vagal targeting of endoplasmic reticulum stress in the trigeminal ganglion alleviates migraine-like behaviors.
Endoplasmic reticulum (ER) stress has emerged as a key player in the development of diverse chronic pain disorders; however, its specific contribution to migraine pathophysiology has yet to be fully elucidated. Although accumulating evidence indicates that transcutaneous auricular vagus nerve stimul…
AI-powered simulated patients with automated feedback for enhancing headache history-taking skills: a convergent mixed-methods study.
Medical students often struggle with headache disorders, which are common but diagnostically challenging due to limited clinical exposure and feedback during early clinical training. This study evaluated the feasibility and effectiveness of an AI-powered simulated patient (AISP) chatbot in enhancing…