Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.
Osteoarthritis (OA) is associated with some comorbidities. However, the consistency of the associations across different countries is unclear. We analysed relationships between OA and 61 comorbidities before and after diagnosis using data from four European primary care databases: the UK, the Nether…
Identifying central positional vertigo to prevent diagnostic pitfalls: A case series and review of literature.
This case series highlights the critical role of radiological imaging in patients presenting with positional vertigo initially suggestive of benign paroxysmal positional vertigo (BPPV) but ultimately attributable to central nervous system pathology. The objective is to raise awareness among clinicia…
The burden of noncommunicable and injury-related nervous system disorders in the Americas, 1990-2023: an analysis of the Global Burden of Disease Study 2023.
Noncommunicable and injury-related nervous system disorders (NINSDs)-including cerebrovascular and neurodegenerative diseases, neurodevelopmental disorders, neuromuscular conditions, brain cancers, and traumatic brain injuries-are major contributors to morbidity, disability, and premature mortality…
A scoping review on the characteristics of chronic pain registries.
Chronic pain represents a major global public health challenge, yet systematic surveillance through patient registries remains unevenly developed. Pain registries offer valuable real-world data to inform clinical practice, research, and policy; however, their global scope, design characteristics, an…
DNAJC12 p.Asp44Gly associated with mild hyperphenylalaninemia and migraine-like headaches: Structural and deep learning analyses.
DNAJC12 encodes a J-domain co-chaperone involved in the function of aromatic amino acid hydroxylases, and its deficiency is associated with hyperphenylalaninemia (HPA) and monoamine neurotransmitter deficiency. We assessed a DNAJC12 c.131A > G (p.Asp44Gly, D44G) variant identified in a 19-…
Sustained relief of chronic headache using percutaneous 60-day peripheral nerve stimulation treatment: 12-month results from a multicenter, prospective clinical study.
The study aimed to assess the long-term durability of pain relief among patients with cervicogenic headache (CGH) or occipital neuralgia (ON) following percutaneous 60-day peripheral nerve stimulation (PNS) treatment. Cervicogenic headache (CGH) and occipital neuralgia (ON) are challenging headache…
Paracentral acute middle maculopathy following physical exertion: A case report.
To report a case of paracentral acute middle maculopathy (PAMM) after physical exertion and to explore possible underlying microvascular mechanisms. A 42-year-old Caucasian man presented with a persistent, unilateral, painless paracentral scotoma that appeared after an intense ski session seven days…