Mechanisms of neuroimmune crosstalk in vestibular disorders: Linking inflammation with neural circuit dysfunction (Review).
Vestibular disorders such as vestibular migraine (VM) and Menière's disease (MD) involve complex interactions between inflammation and neural circuit dysfunction. Emerging evidence highlights neuroimmune crosstalk as a unifying pathophysiological framework. The present review synthesized curren…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Exploring Proximal and Distal Ultrasound-Guided Greater Occipital Nerve Block Approaches in Migraine: A Systematic Review and Meta-Analysis.
To evaluate the effectiveness and safety of proximal and distal ultrasound-guided greater occipital nerve block (US-GONB) in patients with migraine. PubMed, Scopus, Web of Science, and the Cochrane Library were searched up to July 2025. Studies assessing US-GONB in migraine were included. Data were…
Ligustrazine Alleviates Nitroglycerin-Induced Migraine by Regulating Mitochondrial Energy Metabolism Through the Concurrent Regulation of CypD, ANT, and PAR2.
To investigate the protective effects of ligustrazine (Lig) against nitroglycerin (NTG)-induced migraine and explore its underlying mechanisms, with a particular focus on mitochondrial energy metabolism and the coordinated regulation of protease-activated receptor 2 (PAR2), cyclophilin D (CypD), and…
Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)-Derived Pseudodiffusion Coefficient and Perfusion Fraction.
Chronic migraine (CM) is associated with neurobiological alterations beyond episodic attacks, yet cerebral microvascular perfusion changes during the interictal phase of CM remain underexplored. Intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) provides diffusion-derived pseudoper…
Perceived headache responses to exercise in patients with migraine: A cross-sectional study.
To characterize patient-perceived headache responses to exercise in migraine and to identify associated clinical factors using a large-scale registry. Regular exercise is often recommended for patients with migraine; however, it can also trigger migraine attacks. This complex effect makes it challen…
Pregnancy outcomes following exposure to galcanezumab: Analysis of cases from the galcanezumab clinical trials and postmarketing database.
This study was conducted to describe pregnancy outcomes reported following maternal or paternal exposure to galcanezumab in clinical trials and postmarketing surveillance. Galcanezumab is a calcitonin gene-related peptide-inhibiting monoclonal antibody indicated for the preventive treatment of migra…
Somatosensory Profiling in Primary Headache Disorders: Examining Interictal, Diagnostic and Headache Frequency related Alterations.
Migraine and tension-type headache (TTH) are characterized by altered somatosensory processing ictally (during headache). It remains unclear whether such alterations persist interictally (headache-free phase) and whether migraine and TTH share similar or distinct somatosensory profiles. This cross-s…