Laparoscopic discoid resection in rectal endometriosis: When less is more.
Laparoscopic discoid resection represents a conservative surgical alternative to segmental resection in the treatment of rectal deep infiltrating endometriosis (DIE). This technique allows excision of infiltrative lesions while preserving rectal continuity and minimizing postoperative morbidity. Des…
Association between preeclampsia and eclampsia in black women with endometriosis: a scoping review.
Women with endometriosis are at increased risk of preeclampsia and eclampsia, leading causes of maternal mortality among Black women in the United States. Despite this, Black women are significantly underdiagnosed with endometriosis. This scoping review examines how peer-reviewed literature addresse…
Parabacteroides goldsteinii and its metabolite 7-KLCA attenuate endometriosis via TGR5 to reprogram macrophages by modulating the PPARγ/GPR132 axis.
Endometriosis (EMS) remains understudied in effective management strategies. The interplay between macrophage dysfunction and microbiota-derived immune signals emerges as a potential mechanism in EMS pathogenesis, suggesting its relevance for future therapeutic exploration. In this study, we establi…
Serum progesterone concentrations at frozen embryo transfer in women with adenomyosis and endometriosis: a retrospective cohort study.
Endometriosis and adenomyosis are estrogen-dependent inflammatory conditions frequently associated with impaired fertility. Although progesterone resistance at the tissue level is well documented, it remains unclear whether these conditions are associated with altered systemic progesterone exposure…
The effects of endometrial polyps, leiomyomas, adenomyosis, and endometriosis on endometrial receptivity: phenotype, molecular pathways, and clinical implications.
This review synthesizes current evidence on how endometrial polyps, leiomyomas, adenomyosis, and endometriosis influence endometrial receptivity, emphasizing phenotype-specific effects, molecular mechanisms, and implications for embryo transfer outcomes. Impaired endometrial receptivity, when presen…
Bioactive factors in Endometriosis Peritoneal Fluid Remodel Human Cardiomyocytes.
Endometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from women with endometriosis alters cardiomyocyte behavior in vitro. Human-induced pluripotent stem cell-derived card…
Decidualization potential of endometrial mesenchymal stem cells and their role in reproductive health.
The establishment of a successful pregnancy depends on proper embryo development and coordinated endometrial differentiation, particularly through the process of decidualization. Mesenchymal stem/stromal cells (MSCs), especially those derived from endometrial tissue (eMSCs) and menstrual fluid (MenS…
Lesion-centric reprogramming: hydrogel-enabled photothermal reset of endometriosis pain.
Endometriosis-associated pelvic pain represents a prototypical failure of systemic therapy for a locally organized, neuroinflammatory disease. Persistent pain arises from the convergence of estrogen-driven lesion survival, chronic inflammation, fibrosis, and aberrant neuroangiogenesis, leading to su…