Efficacy and safety of modified Gwakjeongtang (herbal medicine) for diarrhea-predominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial.
Irritable bowel syndrome (IBS) significantly impairs quality of life, and current treatments often provide insufficient symptom relief. Gwakjeongtang is the most frequently prescribed herbal medicine for IBS patients in Korea. We aimed to explore the efficacy and safety of modified Gwakjeongtang (mG…
Comparative Effectiveness of Hangeshashinto and Ramosetron for the Treatment of Irritable Bowel Syndrome with Diarrhea.
Background/Aims Evidence-based pharmacological options for irritable bowel syndrome with diarrhea (IBS-D) remain limited, and complementary approaches are of interest. We evaluated the real-world effectiveness of hangeshashinto (TJ-14), ramosetron, and their combination in patients with IBS-D or mix…
Management of bowel dysfunction after pelvic surgery for endometriosis.
Bowel dysfunction is a common and debilitating condition affecting patients with endometriosis. Despite the extent of surgery, symptoms may persist or arise, often overlapping with low anterior resection syndrome (LARS) or irritable bowel syndrome (IBS) typical features. This review aims to summariz…
Toward a Synthetic Data Revolution: Diffusion Model-Enhanced Hepatocellular Carcinoma Prediction in Steatotic Liver Disease.
Steatotic liver disease (SLD) encompasses a heterogeneous spectrum with varying risks of hepatocellular carcinoma (HCC). Limited sample sizes limit the development of predictive models, particularly for rare outcomes. This study evaluated whether generative artificial intelligence (AI)-based synthet…
Comparing implicit boundary and hierarchical plurigaussian simulation for modeling geological domains using hard and soft data.
The delineation of geological domains is a crucial step in mineral resource evaluation, as it directly influences the accuracy of grade models. Instead of a single geological interpretation, geostatistical simulation generates multiple scenarios that reproduce the spatial variability and can be used…
Translation and validation of the Rome IV Functional Gastrointestinal Disease questionnaire for adults and prevalence of functional gastrointestinal disorders in the general Finnish population.
The accurate translation and validation of the Rome IV Functional Gastrointestinal Disease Questionnaire allow for its broader adoption in various clinical and research settings. Our objective was to translate and validate a Finnish version of the Rome IV Questionnaire for use in and to assess the p…
Feasibility and efficacy of fecal microbiota transplantation in adolescents with refractory irritable bowel syndrome: A randomized clinical pilot trial.
To assess the feasibility and efficacy of fecal microbiota transplantation (FMT) in adolescents (16-21 years) with refractory irritable bowel syndrome (IBS). Randomized controlled pilot trial. Thirty-two patients were included and randomized to receive two allogeneic or autologous FMTs. At baseline…
Targeting P2X receptor signaling for chronic visceral pain and beyond.
P2X receptors (P2XRs) are ATP-gated cation channels that play a pivotal role in chronic visceral pain (CVP). This review highlights the central contribution of the ATP-P2X3/4/7 axis in peripheral and central sensitization underlying CVP. Recent discoveries have identified the non-coding RNA miR-1306…