Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
Efficacy and safety of modified Gwakjeongtang (herbal medicine) for diarrhea-predominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial.
Irritable bowel syndrome (IBS) significantly impairs quality of life, and current treatments often provide insufficient symptom relief. Gwakjeongtang is the most frequently prescribed herbal medicine for IBS patients in Korea. We aimed to explore the efficacy and safety of modified Gwakjeongtang (mG…
Identification of Novel Small-Molecule Janus Kinase 1 and 2 Inhibitors Through Structure-Based Virtual Screening, In Vitro Assays, and Molecular Dynamics Simulations.
Janus kinases (JAKs) are central mediators of cytokine-driven signal transducer and activator of transcription (STAT) signaling, and dysregulation of the JAK-STAT axis is implicated in inflammatory, autoimmune, and neoplastic diseases. To identify new small-molecule inhibitors of Janus kinase 1 (JAK…
Decoding the gut-brain axis in irritable bowel syndrome: a cross-sectional analysis of anxiety and depression symptoms in constipation and diarrhoea predominant subtypes.
The gut-brain axis is pivotal in the pathophysiology of irritable bowel syndrome (IBS), with anxiety, depression and quality of life. IBS-C (constipation-predominant) and IBS-D (diarrhoea-predominant) are frequently linked with psychological comorbidities. Neither in Indonesia nor globally has resea…
Plasma proteins and irritable bowel syndrome: A proteome-wide Mendelian randomization study.
Irritable bowel syndrome (IBS) is a complex disorder with unclear etiology and underlying mechanisms. This research aimed to identify possible plasma proteins linked to IBS using a proteome-wide Mendelian randomization (MR) analysis. We performed a bidirectional two-sample MR analysis to investigate…
Fiber supplementation in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.
Fiber supplementation is widely used and recommended for irritable bowel syndrome (IBS), however there is no recent evidence synthesis. We aimed to investigate the efficacy of fiber supplements in IBS through a systematic review and meta-analysis of randomized controlled trials. We searched MEDLINE,…
Irritable bowel syndrome-related symptoms among medical students in Bosnia and Herzegovina.
To determine the prevalence of irritable bowel syndrome (IBS)-related symptoms and associated factors among medical students in Bosnia and Herzegovina. This cross-sectional online survey included 176 medical students from the universities of Sarajevo and Zenica between November 2022 and December 202…
Data-driven subtypes of internalizing and functional somatic symptoms: A hybrid mixture modeling approach.
The mechanisms underlying the high comorbidity between internalizing disorders (IDs) and functional disorders (FDs) remain unclear. This study aimed to identify data-driven subgroups of major depressive disorder (MDD), generalized anxiety disorder (GAD), myalgic encephalomyelitis/chronic fatigue syn…