Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies.
Fecal microbiota transplantation (FMT) holds therapeutic promise beyond recurrent Clostridioides difficile infection, but clinical outcomes remain unpredictable and donor-selection strategies remain limited, in part because the role of donor‒recipient metabolic interactions in shaping the pos…
Development and internal validation of a machine learning-based disease burden index for irritable bowel syndrome: a multicentre cross-sectional study.
Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction in gastroenterology clinics worldwide, becoming a significant public health burden. This study aims to provide an exploratory approach for comprehensive assessment of IBS burden and may serve as a basis for f…
Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trial.
Dietary therapy is central to irritable bowel syndrome (IBS) management, yet the long-term durability of the low-FODMAP diet (LFD), and of microbiome-guided personalization, remains unclear. We assessed the long-term clinical and gut-microbiome effects of a microbiome-guided personalized diet (PD) c…
Comparative machine learning survival models for under-five mortality in Southern Africa with frailty modelling.
Child survival remains central to achieving Sustainable Development Goals (SDGs) 3 and 10, particularly in sub-Saharan Africa where inequalities in health outcomes persist. This study aimed to predict under-five survival in Southern Africa using advanced machine learning survival models and to exami…
Efficacy of Tenapanor in Patients With or Without Prior Use of IBS-C Prescription Medications: A Post-hoc Analysis of Phase 3 Clinical Trials.
Tenapanor is approved for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults. The impact of prior IBS-C prescription treatment(s) on the therapeutic efficacy of tenapanor is unknown. To assess whether prior IBS-C prescription medication use affected clinical response to te…
Avoidant/restrictive food intake across the gastrointestinal tract.
Avoidant/restrictive food intake disorder (ARFID) is characterized by reduced dietary intake leading to medical and/or psychosocial impairment, independent of body image concerns. We aim to assess ARFID screening and characteristics in patients with gastrointestinal disorders versus healthy voluntee…