Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trial.
Dietary therapy is central to irritable bowel syndrome (IBS) management, yet the long-term durability of the low-FODMAP diet (LFD), and of microbiome-guided personalization, remains unclear. We assessed the long-term clinical and gut-microbiome effects of a microbiome-guided personalized diet (PD) c…
Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
Development and internal validation of a machine learning-based disease burden index for irritable bowel syndrome: a multicentre cross-sectional study.
Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction in gastroenterology clinics worldwide, becoming a significant public health burden. This study aims to provide an exploratory approach for comprehensive assessment of IBS burden and may serve as a basis for f…
Comparative machine learning survival models for under-five mortality in Southern Africa with frailty modelling.
Child survival remains central to achieving Sustainable Development Goals (SDGs) 3 and 10, particularly in sub-Saharan Africa where inequalities in health outcomes persist. This study aimed to predict under-five survival in Southern Africa using advanced machine learning survival models and to exami…
Efficacy and safety of modified Gwakjeongtang (herbal medicine) for diarrhea-predominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial.
Irritable bowel syndrome (IBS) significantly impairs quality of life, and current treatments often provide insufficient symptom relief. Gwakjeongtang is the most frequently prescribed herbal medicine for IBS patients in Korea. We aimed to explore the efficacy and safety of modified Gwakjeongtang (mG…
Systematic Review and Meta-Analysis: Plant-Based Therapy for Irritable Bowel Syndrome.
Irritable bowel syndrome (IBS) is a common disorder of brain-gut interaction that presents with abdominal pain, bloating associated with variable stool consistency. Many IBS patients prefer plant-based preparations to pharmacological therapy; however, the utility of this approach is not well establi…
Differences in the Plasma Bile Acid-Gut Microbiota Axis Between IBS-D and IBS-C.
Irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D) exhibit highly divergent clinical manifestations. This study aims to investigate the correlation between IBS-C and IBS-D. All participants provided fecal samples and completed IBS-SSS, IBS-QOL, and GSRS. Fecal bacterial composit…