Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.
Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of the intestinal metabolome associated with dysbiosis can trigger chronic inflammation. However, it remains…
Dr. Daniel L. Kastner, former Scientific Director of the National Human Genome Research Institute (NHGRI), was a visionary physician-scientist whose discoveries transformed the understanding of innate immunity and established the modern field of autoinflammatory diseases. Early in his career, he led…
Carrageenan-induced immunothrombotic models in rodents (Review).
Carrageenan (CGN)-induced immunothrombotic models are used in rodent thrombosis research. They enable both mechanistic dissection of inflammation-coagulation crosstalk and high-throughput screening of antithrombotic agents. The present narrative review summarizes current knowledge on modeling approa…
Factors Associated with Adalimumab Initiation in Non-Infectious Uveitis: A Propensity Score Matched Analysis.
To identify factors associated with adalimumab initiation in non-infectious uveitis. This was a retrospective case-control study using multicentric data of 3204 patients. The primary outcome was whether adalimumab was initiated, and the secondary outcome was time to initiation. To investigate factor…
Attention-Deficit/Hyperactivity Disorder Symptoms in School-Aged Children with a History of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Denitis Syndrome: A Comparative Evaluation with Healthy Peers.
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome of childhood, and growing evidence links early-life inflammation to neurodevelopment, but whether PFAPA affects attention and behavior at school age is unknown. This st…
Neutrophil extracellular trap suppression in rheumatoid arthritis patients treated with biologic therapy: a prospective observational study.
Rheumatoid arthritis (RA) is associated with increased cardiovascular risk, partly driven by chronic systemic inflammation. Neutrophil extracellular traps (NETs) have emerged as important mechanistic links between sustained immune activation and early vascular injury. To evaluate changes in NET-asso…
An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon-Adhesive Shield for Long-Term Neutrophil-Directed Remission of Ulcerative Colitis.
Neutrophil extracellular traps (NETs) perpetuate chronic inflammation in ulcerative colitis (UC), yet current neutrophil-targeting therapies focus on acute intervention rather than sustained daily control. Here, we propose an oral microsupplement for long-term UC management that concurrently scaveng…
Renal AA amyloidosis associated with a TRAPS-like autoinflammatory phenotype and TNFRSF1A R92Q variant in adulthood.
Tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder typically presenting with recurrent febrile attacks. However, adult-onset cases without classical inflammatory symptoms may remain unrecognized and can present with organ-dominant…