What You Need to Know About Sacroiliac Dysfunction.
Low back pain is the leading cause of disability worldwide, and sacroiliac dysfunction is estimated to occur in 15%-30% of those with nonspecific low back pain. Nurses are in the unique position to support and provide education to patients who may be experiencing sacroiliac dysfunction or possibly a…
Structural progression in ankylosing spondylitis (AS) is difficult to model in species with human-relevant spinal anatomy and long-term imaging readouts. Here, we established a rhesus macaque model of AS-like structural remodeling by standardized posterior L2-L6 musculoligamentous injury, with sham-…
Assessment of active and inactive sacroiliitis in axial spondyloarthritis using DCE-MRI and ZOOMit-DWI parameters: A prospective study.
Accurate assessment of sacroiliac joint disease activity is essential in axial spondyloarthritis. We evaluated the safety and diagnostic utility of quantitative and semiquantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters together with ZOOMit-DWI-derived apparent di…
Phase II randomised, placebo-controlled study to evaluate the efficacy and safety of an MK2 inhibitor in ankylosing spondylitis.
CC-99677 (BMS-986371) is a novel, small-molecule covalent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2). We aimed to evaluate the dose-dependent efficacy and safety of CC-99677 compared with placebo in subjects with ankylosing spondylitis (AS). This was a phase II, m…
Acute Motor Axonal Neuropathy Coexisting With Ankylosing Spondylitis: A Case-Based Review.
Guillain-Barré syndrome (GBS) is a rare autoimmune disorder characterized by peripheral nerve involvement. Among the many kinds of GBS, acute motor axonal neuropathy (AMAN) syndrome has been shown to have distinct clinical characteristics and consequences. Meanwhile, ankylosing spondylitis (AS)…
Editorial Commentary: Hip Arthroscopy in Patients With Symptomatic Spine Pathology: Patient Education Supported by Diagnostic Injections Is the Key to Satisfactory Outcomes.
Concomitant correctable and uncorrectable pathologies can impact outcomes after any orthopaedic procedure. The relationship between hip joint disorders and spine-related disorders has been increasingly recognized and reported in the literature. A number of studies have reported poorer outcomes in pa…
Utility of minimally invasive percutaneous arthrodesis of the sacroiliac joint for the treatment of low back pain: systematic review of the literature.
The surprising increase observed in recent years in the use of minimally invasive sacroiliac joint arthrodesis techniques as a treatment for low back pain justifies an objective review of this results. carry out a systematic review of the literature to evaluate the clinical results of patients with…
Sacroiliac dysfunction and minimally invasive sacroiliac joint fusion.
The sacroiliac joint (SIJ) is the largest diarthrodial joint in the human body and accounts for approximately 20% of all low back pain, which is commonly seen in patients with lumbosacral fusions. Despite this, SIJ dysfunction often poses a challenging diagnosis depending on clinical evaluation, ima…