What You Need to Know About Sacroiliac Dysfunction.
Low back pain is the leading cause of disability worldwide, and sacroiliac dysfunction is estimated to occur in 15%-30% of those with nonspecific low back pain. Nurses are in the unique position to support and provide education to patients who may be experiencing sacroiliac dysfunction or possibly a…
Efficacy and safety of filgotinib in patients with active radiographic and nonradiographic axial spondyloarthritis: results from OLINGUITO, a phase 3 trial consisting of 2 randomised, placebo-controlled, double-blind, parallel-group studies.
This study aimed to investigate the efficacy and safety of filgotinib, a JAK1 preferential inhibitor, in patients with axial spondyloarthritis (axSpA). The phase 3 OLINGUITO trial comprises 2 international, randomised, double-blind, placebo (PBO)-controlled studies. Patients with an established diag…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Exploratory MRI and Clinical Marker Analysis of Pustulotic Arthro-Osteitis Disease Activity From a Phase 3 Brodalumab Trial.
Pustulotic arthro-osteitis (PAO) is a clinically important osteoarticular comorbidity affecting approximately 9%-28% of patients with palmoplantar pustulosis (PPP), yet early recognition and standardized activity assessment remain challenging, particularly in routine dermatology practice. This explo…
MRI Evaluation of Axial Spondyloarthritis: From Early Diagnosis to Therapeutic Response Assessment.
Magnetic resonance imaging (MRI) has reshaped the evaluation of axial spondyloarthritis (axSpA), which comprises radiographic axSpA (historically ankylosing spondylitis) and non-radiographic axSpA, by demonstrating active inflammation and structural lesions before definitive radiographic sacroiliiti…
EXTL3 dysfunction identified as a driver of aberrant bone development in severe familial ankylosing spondylitis.
Pathological ossification leading to spinal ankylosis is a hallmark of ankylosing spondylitis (AS), yet its molecular mechanisms remain poorly understood. We investigated the genetic basis and functional consequences of severe familial AS to identify pathways driving structural progression. Genome-w…
Development of a pelvic musculoskeletal model based on statistical shape modelling for estimating sacroiliac and pubic joint reaction forces in females.
The sacroiliac joints (SIJs) and pubic symphysis (PS) form a 'pelvic ring' that plays a critical role in load transfer between the spine and lower extremities. Direct in vivo measurement of pelvic joint loading remains challenging, and existing musculoskeletal models often simplify or exclude pubic…
Mitigating radiation in robotic-assisted sacropelvic screw placement using 3D magnetic resonance imaging.
To evaluate the feasibility and accuracy of robotic-assisted (RA) sacropelvic screw placement (SPSP) using three-dimensional magnetic resonance imaging (3D MRI) for preoperative planning and robotic registration. SPSP is a critical component of spinal fixation but is subject to trajectory deviations…