What You Need to Know About Sacroiliac Dysfunction.
Low back pain is the leading cause of disability worldwide, and sacroiliac dysfunction is estimated to occur in 15%-30% of those with nonspecific low back pain. Nurses are in the unique position to support and provide education to patients who may be experiencing sacroiliac dysfunction or possibly a…
Efficacy and safety of filgotinib in patients with active radiographic and nonradiographic axial spondyloarthritis: results from OLINGUITO, a phase 3 trial consisting of 2 randomised, placebo-controlled, double-blind, parallel-group studies.
This study aimed to investigate the efficacy and safety of filgotinib, a JAK1 preferential inhibitor, in patients with axial spondyloarthritis (axSpA). The phase 3 OLINGUITO trial comprises 2 international, randomised, double-blind, placebo (PBO)-controlled studies. Patients with an established diag…
[The role of NLRP3 inflammasome in the pathogenesis of ankylosing spondylitis research progress].
Ankylosing Spondylitis(AS) is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, with a higher prevalence in young males. Without timely diagnosis and treatment, it can progress to spinal ankylosis, joint function loss, and disability. The exact pathogenesis remains…
¹⁸F-sodium fluoride PET/CT as a complementary measure of osteoblastic disease burden in axial spondyloarthritis: a prospective exploratory study.
To determine whether SIJ ¹⁸F-NaF uptake is associated with MRI-defined inflammation and structural damage and whether it provides a complementary measure of osteoblastic disease burden. In this prospective exploratory study, 43 adults with chronic low back pain underwent pelvic radiograp…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Co-occurrence of Voiding Symptoms and Flatal Incontinence in Axial Spondyloarthritis: A Cross-Sectional Study.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the sacroiliac joints and spine whose burden extends beyond the musculoskeletal system. Lower urinary tract symptoms are increasingly recognised in these patients, whereas anorectal symptoms have received almost no attention. Becau…
International Imaging Practices for Sacroiliac Joint MRI Acquisition Protocols in Patients with Juvenile Spondylarthritis.
Background/Objective: International recommendations exist for MRI evaluation of sacroiliac joints (SIJs) in adult spondylarthritis (SpA) and other joints in juvenile (J)SpA. However, consensus recommendations for MRI acquisition protocols for SIJs in JSpA are lacking. Our survey gathered information…
Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated with High Structural Damage in Ankylosing Spondylitis.
Pathological bone formation in ankylosing spondylitis (AS) is not fully reflected by systemic inflammation, limiting the utility of inflammatory markers for structural damage assessment. This study aimed to identify plasma protein signatures associated with structural damage severity in AS. Deep pla…