Uncovering Causal Links Between Autoimmune Diseases and Muscular Dystrophy: A Bidirectional Mendelian Randomization Study.
Muscular dystrophies (MDs) are inherited neuromuscular disorders characterized by progressive muscle degeneration. Although their genetic causes are well known, the contribution of autoimmune diseases to MD risk remains unclear. To address this gap, we performed a bidirectional two-sample Mendelian…
Perioperative use of disease-modifying anti-rheumatic drugs (DMARDs) in people with inflammatory arthritis.
Disease-modifying anti-rheumatic drugs (DMARDs) are the cornerstone of pharmacologic treatment for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis). DMARDs are immunomodulatory drugs which may increase the risk of infection, including surgical site infec…
Real-World Upadacitinib Persistence and Clinical Outcomes Among Canadian Patients with Inflammatory Arthritis from a Patient Support Program: The UPRAISE Study.
Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) impact quality of life. Medication persistence is a key determinant of long-term effectiveness in chronic inflammatory diseases. This study evaluated treatment persistence, function, and program satisfaction am…
Performance of Large Language Models in Differentiating Systemic Lupus Erythematosus From Mimicking Conditions Using the 2019 EULAR/ACR Criteria: A Comparative Analysis.
Systemic Lupus Erythematosus (SLE) presents a significant diagnostic challenge for clinicians due to its diverse clinical manifestations and overlap with other autoimmune conditions. Large Language Models (LLMs) are currently regarded as having the potential to assist clinicians in expediting decisi…
Post-Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta-Analysis of Associated Factors.
Post-dengue fatigue syndrome is a debilitating long-term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post-dengue depression complicate differentiation. Therefore, we conducted a systematic review…
Phenotypes of Chronic Overlapping Pain Multimorbidity in Rheumatology: A Population-Based Claims Study.
This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008-2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 p…
Assessment of active and inactive sacroiliitis in axial spondyloarthritis using DCE-MRI and ZOOMit-DWI parameters: A prospective study.
Accurate assessment of sacroiliac joint disease activity is essential in axial spondyloarthritis. We evaluated the safety and diagnostic utility of quantitative and semiquantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters together with ZOOMit-DWI-derived apparent di…
Two-sample Mendelian randomization analysis unveils a potential genetic association between rheumatic diseases and the risk of idiopathic pulmonary fibrosis.
This study aims to elucidate the genetically causal link between rheumatic diseases and idiopathic pulmonary fibrosis (IPF) using Mendelian randomization (MR) analysis. Genome-wide association studies data for IPF were sourced from the FINN cohort in the IEU database, rheumatoid arthritis (RA), syst…