Efficacy and safety of filgotinib in patients with active radiographic and nonradiographic axial spondyloarthritis: results from OLINGUITO, a phase 3 trial consisting of 2 randomised, placebo-controlled, double-blind, parallel-group studies.
This study aimed to investigate the efficacy and safety of filgotinib, a JAK1 preferential inhibitor, in patients with axial spondyloarthritis (axSpA). The phase 3 OLINGUITO trial comprises 2 international, randomised, double-blind, placebo (PBO)-controlled studies. Patients with an established diag…
[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival.
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the expression of BAX protein in Jurkat T cells, as shown in the western blots in Fig. 6A on p. 3392, was unexpected, since Jurkat cells have been reported to be BAX‑null [see the p…
Zhuangdu Quhan Mixture Alleviates Ankylosing Spondylitis in Mice by Inhibiting the Interleukin-17 Signaling.
This study aimed to elucidate the therapeutic effect and mechanism of Zhuangdu Quhan Mixture (ZDQHM) in ankylosing spondylitis (AS). An AS mouse model was established in mice using β-glucan. Therapeutic efficacy was assessed through arthritis scores, histopathology, serum cytokine measurement…
Association between osteoporosis and arthritis: Results from the NHANES and Mendelian randomization study.
This study seeks to investigate associations of osteoporosis (OP) with arthritis and to assess causality using Mendelian randomization (MR). Firstly, an observational study was conducted using the National Health and Nutrition Examination Survey (NHANES). The relationship between OP and arthritis wa…
Surgical outcomes following spinal fusion for cervical versus noncervical fractures in ankylosing spondylitis and DISH.
Ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) are 2 distinct spondyloarthropathies characterized by progressive spinal ankylosis. Despite their differing pathophysiologies, both conditions create long rigid spinal segments that are vulnerable to unstable fractures.…
Long-term functional and radiological outcomes among survivors of ankylosing spondylitis-associated cervical spine fractures: a cross-sectional follow-up study.
Patients with ankylosing spondylitis (AS) are predisposed to unstable cervical spine fractures, often following low-energy trauma. While short-term outcomes have been described, long-term functional and radiological outcomes among survivors remain poorly characterized. Survivor cohort study with com…
The Integrin Signature of Ankylosing Spondylitis: Divergent Regulation of CD29 and CD49b in HLA-B27-Positive Cohorts in Iraqi Patients.
Ankylosing spondylitis (AS) is a systemic inflammatory disorder where the HLA-B27 allele significantly influences disease severity. This study evaluated the molecular profiles of integrins CD29 and CD49b in peripheral blood mononuclear cells (PBMCs) to identify potential biomarkers associated with H…
Digital physical-activity engagement and 12-week patient-reported outcomes in inflammatory arthritis: a retrospective real-world cohort study.
Physical activity is a key component of inflammatory arthritis (IA) management, yet real-world evidence on digital exercise-support tools remains limited. To examine whether physical-activity action plan (PA_AP) engagement over 12 weeks is associated with changes in the Health Assessment Questi…