Efficacy and safety of filgotinib in patients with active radiographic and nonradiographic axial spondyloarthritis: results from OLINGUITO, a phase 3 trial consisting of 2 randomised, placebo-controlled, double-blind, parallel-group studies.
This study aimed to investigate the efficacy and safety of filgotinib, a JAK1 preferential inhibitor, in patients with axial spondyloarthritis (axSpA). The phase 3 OLINGUITO trial comprises 2 international, randomised, double-blind, placebo (PBO)-controlled studies. Patients with an established diag…
Focused Extracorporeal Shock Wave Therapy Versus Therapeutic Ultrasound as Adjuncts to Exercise-Based Rehabilitation for Functional Limitation in Ankylosing Spondylitis: An Assessor-Blinded Randomized Comparative Trial.
The comparative effectiveness of adjunctive physical modalities alongside exercise for ankylosing spondylitis (AS) remains inadequately evaluated. To compare the relative association of focused extracorporeal shock wave therapy (ESWT) versus therapeutic ultrasound, both added to identical exercise-b…
Neurosurgical Manifestations of Rheumatologic Diseases: Clinical, Imaging, and Surgical Implications.
This article reviews the neurosurgical considerations and clinical manifestations of giant cell arteritis, rheumatoid arthritis-related cervical spine disease, ankylosing spondylitis, systemic lupus erythematosus, neurosarcoidosis, and Lyme disease. Across these disease entities, neurosurgical urgen…
Surgical technique, outcomes and complications of conversion total hip arthroplasty in ankylosed hip operated through the posterior approach: A retrospective cohort study.
Conversion total hip arthroplasty (THA) in ankylosed hips is technically challenging because of distorted anatomy, soft-tissue contractures, and compromised bone quality. Flexion, abduction, and external rotation deformities, common in inflammatory conditions, further restrict visualization of the f…
Differentiation of axial spondyloarthritis-related lesions from degenerative lesions on Na[18F]Fluoride PET/CT in a longitudinal dataset of patients with radiographic axial spondyloarthritis.
To investigate longitudinal changes of Na[18F]Fluoride uptake in the axial skeleton of patients with radiographic axial spondyloarthritis (r-axSpA) during biological treatment, focusing on r-axSpA and degenerative (D) lesions. 20 active r-axSpA patients were included. Na[18F]Fluoride Positron Emissi…
Exploring potential association between bisphenol A exposure and spondyloarthritis: Integrative evidence from molecular analyses and NHANES.
Spondyloarthritis (SpA), including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), involves complex interactions between genetic susceptibility and environmental factors. Bisphenol A (BPA), an endocrine-disrupting chemical with immunomodulatory properties, may influence immune regulation,…
Effectiveness of interleukin (IL)-23 and IL-12/23 inhibitors and factors associated with response in psoriatic arthritis with axial involvement: the APxis-IL12-23 study.
To assess the real-world effectiveness of two interleukin (IL)-23 inhibitors [guselkumab (GUS), risankizumab (RIS)] and an IL-12/23 inhibitor [ustekinumab (UST)] in patients with purely axial psoriatic arthritis (PsA) or mixed PsA (both axial and peripheral involvement), and identify response predic…
Altered Fetal Adrenal Gland Morphometry and Middle Adrenal Artery Doppler in Pregnancies With Rheumatoid Arthritis and Ankylosing Spondylitis: A Prospective Case-Control Study.
To evaluate fetal adrenal gland (FAG) dimensions and middle adrenal artery (MAA) Doppler parameters in pregnancies complicated by rheumatoid arthritis (RA) and ankylosing spondylitis (AS), collectively termed inflammatory arthritis (IA), compared with healthy controls. This study enrolled 46 singlet…