Surgical strategies and sequencing decisions for ankylosing spondylitis with severe hip deformity.
Advanced ankylosing spondylitis (AS) may involve both the thoracolumbar spine and the hips, resulting in a complex deformity characterized by kyphosis, pelvic retroversion, and hip ankylosis. In severe cases, both pedicle subtraction osteotomy (PSO) and total hip arthroplasty (THA) may be required,…
Balance impairment, vestibular dysfunction, and fear of falling in patients with ankylosing spondylitis: a controlled posturographic study.
Ankylosing spondylitis (AS) may impair postural control and balance through musculoskeletal and proprioceptive alterations. To evaluate vestibulo-ocular reflex parameters, balance performance, and fear of falling in patients with AS compared with healthy controls. This prospective controlled study i…
Real-world effectiveness and safety of apremilast in psoriatic arthritis: results from the multicenter Italian MAPSI II study.
To assess the effectiveness and safety of apremilast in the treatment of psoriatic arthritis (PsA) in a real-world setting across multiple rheumatology centers in Italy. MAPSI II is a multicenter, observational real-world study including adult patients with active PsA treated with apremilast. Patien…
Biologics reduced infections in ankylosing spondylitis and psoriatic arthritis under immunosuppressants.
Biologic disease-modifying antirheumatic drugs (bDMARDs) alleviate inflammation but may have immunocompromising effects. Previous studies evaluating infection risks in spondyloarthritis (SpA) have yielded inconsistent conclusions. We investigated infection risk in patients with ankylosing spondyliti…
Introducing the Global Exploration of Psoriatic Arthritis Disease Activity Assessment (EXPLORE-PsA): The First Young-GRAPPA Research Initiative.
Despite international recommendations advocating for structured assessment of disease activity in psoriatic arthritis (PsA), the routine use of outcome measures in clinical practice remains inconsistent. Barriers such as limited time, lack of training, and restricted access to resources may be contr…
Defining the relationship between the hip, pelvis, and lumbar spine.
While the hip, pelvis, and lumbar spine are known to move synchronously, their exact relationship has yet to be determined. The aim of this study was to define the biomechanical relationship between the hip, pelvis, and lumbar spine. A cohort of fifty healthy subjects between 18- and 35-years-old we…
Population Pharmacokinetics of Oral Gecacitinib in Healthy Subjects and Patients with Autoimmune and Inflammatory Diseases.
Gecacitinib is a novel, broad-spectrum Janus kinase (JAK) inhibitor being developed for the treatment of myelofibrosis, severe alopecia areata, ankylosing spondylitis, and atopic dermatitis. This study aimed to develop population pharmacokinetic (PopPK) models for gecacitinib and its metabolites ZG0…
Recent updates in human leukocyte antigen B27-associated uveitis.
There has been progressive understanding in etiopathogenesis, clinical presentation, and effective treatment of anterior uveitis (AU) over the years. Sudden onset, symptomatic acute anterior uveitis (AAU) in a young adult, often male, classically arouses suspicion for human leukocyte antigen (HLA) B…