Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population.
Psoriasis vulgaris (PsV) is a complex immune-mediated disease with a polygenic component. Common variants in the vitamin D receptor (VDR) gene have been explored in the context of psoriasis, but findings remain inconsistent and data from the Greek population are scarce. Thus, the present study aimed…
Real-world effectiveness and safety of apremilast in psoriatic arthritis: results from the multicenter Italian MAPSI II study.
To assess the effectiveness and safety of apremilast in the treatment of psoriatic arthritis (PsA) in a real-world setting across multiple rheumatology centers in Italy. MAPSI II is a multicenter, observational real-world study including adult patients with active PsA treated with apremilast. Patien…
Guselkumab Safety in Patients With Latent Tuberculosis: Analysis of 11 Studies in Psoriatic Disease.
Certain psoriatic disease treatments, including tumor necrosis factor-α inhibitors (TNFi), increase tuberculosis (TB) risk. Testing for latent TB infection (LTBI) before initiating systemic therapy has been standard practice for psoriasis (PsO) patients; however, updated consensus states routi…
Introducing the Global Exploration of Psoriatic Arthritis Disease Activity Assessment (EXPLORE-PsA): The First Young-GRAPPA Research Initiative.
Despite international recommendations advocating for structured assessment of disease activity in psoriatic arthritis (PsA), the routine use of outcome measures in clinical practice remains inconsistent. Barriers such as limited time, lack of training, and restricted access to resources may be contr…
Biologics reduced infections in ankylosing spondylitis and psoriatic arthritis under immunosuppressants.
Biologic disease-modifying antirheumatic drugs (bDMARDs) alleviate inflammation but may have immunocompromising effects. Previous studies evaluating infection risks in spondyloarthritis (SpA) have yielded inconsistent conclusions. We investigated infection risk in patients with ankylosing spondyliti…
Imaging in Psoriatic Arthritis: Focus on Axial Magnetic Resonance Imaging and Peripheral Musculoskeletal Ultrasound.
Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease characterized by diverse musculoskeletal manifestations, including peripheral and axial arthritis, enthesitis, and dactylitis, often in conjunction with skin and nail psoriasis. Imaging modalities, particularly musculoskeletal ultraso…
A spatial transit-retention axis reveals adaptive immune organisation in psoriatic disease.
Spatial organisation of immune cells reflects a balance between tissue anchoring and migratory compatibility, yet how this balance is structured within inflammatory skin disease remains poorly understood. Spatial transcriptomic analyses defined transit-retention immune organisation across lesional a…