Oral Minoxidil for Alopecia in Systemic Sclerosis, Dermatomyositis, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease: A Retrospective Chart Review on Cardiovascular Risk.
Anti-centromere antibody positivity: a spectrum of clinical diagnoses and immunological patterns in a large patient cohort.
Anti-centromere antibody (ACA) positivity is recognized in diverse autoimmune diseases beyond systemic sclerosis (SSc). This study aimed to comprehensively characterize the clinical spectrum and serological profiles of ACA-positive (anti-CENP-B-positive) patients in a large cohort. This retrospectiv…
From Undifferentiated Connective Tissue Disease to Common Variable Immunodeficiency: A Novel NFKB1 Mutation in a Pediatric Case.
Common variable immunodeficiency (CVID) may initially manifest as undifferentiated connective tissue disease (UCTD) in the absence of recurrent infections or hypogammaglobulinemia. In patients presenting with warning signs, neither older age nor normal immunoglobulin levels should preclude considera…
A clinicopathological study on the associations between ranulas and autoimmune diseases.
The study aimed to investigate autoimmune disease (AD) prevalence in ranula patients, analyse their clinicopathological features, and explore the associations between ADs and ranulas. This cross-sectional study enrolled surgically treated ranula patients between 2021 and 2023. AD diagnosis was estab…
Eosinophilic Fasciitis With Overlap Connective Tissue Disease: A Diagnostic Challenge in Progressive Skin Fibrosis.
Eosinophilic fasciitis (EF) is a rare connective tissue disorder characterized by inflammation and fibrosis of the deep fascia and adjacent subcutaneous tissue. Because its clinical presentation may resemble systemic sclerosis (SSc), diagnosis can be delayed, particularly in patients with an establi…
Factors associated with elevated serum IgG4 in rheumatic diseases: A retrospective single-center observational study.
Elevated serum immunoglobulin G4 (IgG4) levels have been reported in various rheumatic diseases; however, the factors associated with IgG4 elevation remain incompletely understood. This study aimed to evaluate the frequency of elevated serum IgG4 in different rheumatic diseases and to explore its as…
The Role of Anti-Phosphatidylserine/Prothrombin Antibodies and the Lectin Complement Pathway in Anti-Phospholipid Antibody-Associated Preterm Delivery.
Antiphospholipid antibodies (aPL) may directly affect placentation and trigger local complement-mediated inflammation/thrombosis. Obstetric complications in the antiphospholipid syndrome (APS) are still frequent despite therapy/close monitoring, and the identification of new risk biomarkers is an un…
NIPT failure due to excessive chromosomal aberrations in an autoimmune pregnancy.
Noninvasive prenatal testing (NIPT) has been widely adopted in clinical practice for screening fetal aneuploidies and copy number variations (CNVs). However, a small proportion of cases exhibit unexplained test failures. This study reports a case with NIPT results showing Z-scores exceeding the refe…