Undifferentiated Connective Tissue Disease

A clinicopathological study on the associations between ranulas and autoimmune diseases.

The study aimed to investigate autoimmune disease (AD) prevalence in ranula patients, analyse their clinicopathological features, and explore the associations between ADs and ranulas. This cross-sectional study enrolled surgically treated ranula patients between 2021 and 2023. AD diagnosis was estab…

Lacrimal gland ultrasonography as an adjunct tool for Sjögren disease (SjD) diagnosis from undifferentiated connective tissue diseases.

Sjögren disease (SjD) is characterized by autoimmune lymphocytic infiltration of lacrimal and salivary glands, leading to dry eye and dry mouth. This study aimed to investigate the features and diagnostic value of lacrimal gland ultrasonography (LGUS) for distinguishing SjD from undifferentiate…

Performance of Large Language Models in Differentiating Systemic Lupus Erythematosus From Mimicking Conditions Using the 2019 EULAR/ACR Criteria: A Comparative Analysis.

Systemic Lupus Erythematosus (SLE) presents a significant diagnostic challenge for clinicians due to its diverse clinical manifestations and overlap with other autoimmune conditions. Large Language Models (LLMs) are currently regarded as having the potential to assist clinicians in expediting decisi…

NIPT failure due to excessive chromosomal aberrations in an autoimmune pregnancy.

Noninvasive prenatal testing (NIPT) has been widely adopted in clinical practice for screening fetal aneuploidies and copy number variations (CNVs). However, a small proportion of cases exhibit unexplained test failures. This study reports a case with NIPT results showing Z-scores exceeding the refe…

Frequency and clinical effect of the presence of anti-DFS70 antibodies in a large cohort of patients with undifferentiated connective tissue disease.

Subclinical atherosclerosis in patients with undifferentiated connective tissue disease: comparison with rheumatoid arthritis.

To investigate the lipid profile and subclinical atherosclerosis in patients with undifferentiated connective tissue disease (UCTD), in comparison with rheumatoid arthritis (RA) and healthy individuals. This cross-sectional controlled study included 30 patients with UCTD, treated with conventional s…

Can Baseline Features Predict Progression to Defined CTD? Insights from a Minimum 5-Year Follow-Up Study of 504 Patients with UCTD.

Undifferentiated connective tissue disease (UCTD) represents a systemic autoimmune condition characterized by clinical and serological features suggestive of defined connective tissue diseases (CTDs), yet insufficient to fulfill existing classification criteria. Despite increasing interest, long-ter…

Recurrent severe thrombocytopenia induced by anti-HER2 therapy in a breast cancer patient with an underlying immune disorder: a case report and literature review.

This case report describes a 51-year-old female with HER2-positive breast cancer who developed recurrent, severe thrombocytopenia during treatment with trastuzumab and pertuzumab. Through a retrospective analysis of her entire treatment course-encompassing neoadjuvant, adjuvant, and radiotherapy pha…