Ramadan fasting in patients with primary adrenal insufficiency: evaluation of the risk of complications, quality of life and sleep, and associated factors.
The study aimed to evaluate the risk of complications, quality of life (QoL) and quality of sleep (QoS) during Ramadan fasting (RF) in patients with primary adrenal insufficiency (PAI) and determine the associated factors. It was an interventional, randomised, crossover, self-controlled study, inclu…
Performance assessment of a novel fully automated ELISA for anti-IA2 autoantibody detection in type 1 diabetes.
Autoantibodies to insulinoma-associated antigen 2 (IA2) are well-established biomarkers of islet autoimmunity, supporting the diagnosis and risk stratification of type 1 diabetes (T1D). This study presents the analytical and clinical evaluation of a newly developed bridge-type Anti-IA2 ELISA (Euroim…
Cytotoxic Lesions of the Corpus Callosum Associated With Addison's Disease: A Case Report.
Cytotoxic Lesions of the Corpus Callosum (CLOCCs) are transient splenial lesions typically triggered by infections, trauma, or metabolic disturbances. This report documents a unique case of a 13-year-old girl with CLOCCs secondary to Addison's disease, an association not previously reported. The pat…
Beyond glycaemic control: autoimmune polyglandular syndrome type 3 as an emerging distinct entity rather than a mere comorbidity in paediatric type 1 diabetes.
Autoimmune polyglandular syndrome type 3 (APS-3) is the coexistence of autoimmune thyroid disease (AITD) with type 1 diabetes (T1D) or other autoimmune diseases, after exclusion of adrenal insufficiency. We aimed to evaluate the prevalence, timeline and features of APS-3 in children and adolescents…
Emergencies in rheumatology can present with a wide range of symptoms and findings, often requiring rapid diagnostics and treatment to prevent permanent damage or avert life-threatening conditions. This article aims to provide an overview of important differential diagnoses that should be consi…
[Association of vitiligo with endocrine autoimmune diseases: literature review].
Vitiligo is a dermatological disease characterized by focal disappearance of the melanin pigment on the skin and mucous membranes of a person. Despite the variety of proposed hypotheses for the development of this pathology, the central role belongs to the autoimmune mechanism of melanocyte damage.A…
IFN-γ-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison's disease.
Autoimmune Addison's disease (AD) is a rare but life-threatening disorder caused by immune-mediated destruction of the adrenal cortex, and progress in therapy has been limited by insufficient mechanistic insight. Here, we establish a model of experimental autoimmune adrenalitis that recapitulates ke…
Iron Deficiency in Endocrine Diseases and the Therapeutic Role of Liposomal Iron: A Comprehensive Review.
Iron deficiency (ID) represents one of the most prevalent nutritional disorders worldwide, affecting approximately 1.2 billion individuals. Beyond its well-established hematological consequences, emerging evidence demonstrates that ID profoundly impacts endocrine function across multiple organ syste…