Impact of Alert Systems on Glucocorticoid Administration for Adrenal Insufficiency in the Emergency Department.
Inappropriate glucocorticoid management in adrenal insufficiency (AI) can lead to adrenal crises, particularly in an emergency setting. Clinical decision support (CDS) can be helpful, but its impact on AI management in emergency departments (EDs) remains limited. To evaluate the efficacy of CDS on g…
Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK.
With an increasing trend in the prevalence of maternal autoimmune diseases in pregnancy, there is need for evidence on the association between autoimmune diseases and pregnancy outcomes. This population-based cohort study used data on pregnancies from primary care practices that contributed to the U…
Addison's disease in Italy: mortality and survival by etiology.
Data on survival and mortality in Addison's disease (AD) are contradictory: some studies suggest a mortality rate two times higher than in the general population, but this is not consistently reported in other studies. We evaluated survival and mortality in 1,826 Italian adult patients with AD of di…
Successful Therapeutic Approach to Facial Hyperpigmentation Secondary to Addison's Disease: A Case Report and Literature Review.
Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder characterized by deficient glucocorticoid and mineralocorticoid production, frequently associated with cutaneous hyperpigmentation due to chronic elevation of adrenocorticotropic hormone. Facial hyperpigmentation may p…
Primary adrenal insufficiency is a rare disease characterized by deficient production of glucocorticoids with or without a deficiency of mineralocorticoids and adrenal androgens.1 This disease can present as a range of symptoms provoking a visit to the emergency department (ED). In this case, we pre…
Disseminated histoplasmosis presenting as primary adrenal insufficiency in an immunocompetent host in the United States: a case report.
Histoplasma capsulatum is a dimorphic fungus that is mostly seen in immunocompromised individuals. Its presentation ranges from acute pulmonary infections to disseminated disease that can affect multiple organ systems, including the adrenal glands. Dissemination is uncommon in immunocompetent hosts,…
Beyond Malignancy: Clinical Insights from Three Cases of Severe Hypercalcemia.
Severe hypercalcemia is a life-threatening condition requiring immediate treatment alongside a systematic evaluation to identify the underlying cause. Although malignancy is a common etiology among hospitalized patients, alternative causes must be considered to guide targeted therapy, as illustrated…
Frequency of abnormal C-reactive protein concentrations in blood of dogs with hypoadrenocorticism.
C-reactive protein (CRP) concentration in serum or plasma is high in humans during adrenal crisis due to multiple mechanisms, however, the frequency and clinical relevance of high CRP concentrations in dogs with hypoadrenocorticism are unknown. To determine the frequency of high CRP concentrations i…