Pseudo-Addisonian Crisis With Hyponatremia and Hyperkalaemia in a Late Pregnant Bitch.
A 3-year-old pregnant Golden Retriever bitch was presented 52 days after ovulation for nausea, hyporexia, regurgitation, polyuria, and polydipsia. Reproductive ultrasound demonstrated several viable foetuses, and the bitch was treated conservatively. Two days later, the bitch was hospitalized due to…
Carbamazepine-Induced Drug-Induced Hypersensitivity Syndrome With Primary Adrenal Insufficiency: A Case Report.
Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms, is a severe adverse reaction involving multiple organs. We describe a case of carbamazepine (CBZ)-induced DIHS with rare primary endocrine complications. A 71-year-old Japanese man dev…
A case of immune thrombocytopenia complicated by catastrophic antiphospholipid antibody syndrome and subsequent intramuscular haemorrhage.
Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) are autoimmune disorders that may coexist, creating a challenging clinical scenario characterised by bleeding risk alongside paradoxically increased thrombotic risk. Catastrophic antiphospholipid syndrome (CAPS) is a rare but life-thr…
Approach to thyroid disorders associated with immune checkpoint inhibitors and tyrosine kinase inhibitors.
Immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) have revolutionised the therapeutic landscape for a range of malignancies. However, their use is frequently associated with immune-related adverse events (irAEs), particularly affecting the endocrine system. Thyroid dysfunctio…
Impact of Alert Systems on Glucocorticoid Administration for Adrenal Insufficiency in the Emergency Department.
Inappropriate glucocorticoid management in adrenal insufficiency (AI) can lead to adrenal crises, particularly in an emergency setting. Clinical decision support (CDS) can be helpful, but its impact on AI management in emergency departments (EDs) remains limited. To evaluate the efficacy of CDS on g…
Addison's disease in Italy: mortality and survival by etiology.
Data on survival and mortality in Addison's disease (AD) are contradictory: some studies suggest a mortality rate two times higher than in the general population, but this is not consistently reported in other studies. We evaluated survival and mortality in 1,826 Italian adult patients with AD of di…
Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK.
With an increasing trend in the prevalence of maternal autoimmune diseases in pregnancy, there is need for evidence on the association between autoimmune diseases and pregnancy outcomes. This population-based cohort study used data on pregnancies from primary care practices that contributed to the U…
Primary Malignant Melanoma of the Mandible: A Diagnostic Dilemma and Surgical Management of a Rare Entity.
Oral malignant melanoma (OMM) is a rare but highly aggressive malignancy that develops in the mucosal lining of the oral cavity. Of all primary melanoma cases, those arising from the oral cavity are extremely uncommon, and among these, involvement of the mandible as the primary site is even rarer. A…