Addison's disease in Italy: mortality and survival by etiology.
Data on survival and mortality in Addison's disease (AD) are contradictory: some studies suggest a mortality rate two times higher than in the general population, but this is not consistently reported in other studies. We evaluated survival and mortality in 1,826 Italian adult patients with AD of di…
Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK.
With an increasing trend in the prevalence of maternal autoimmune diseases in pregnancy, there is need for evidence on the association between autoimmune diseases and pregnancy outcomes. This population-based cohort study used data on pregnancies from primary care practices that contributed to the U…
Disseminated histoplasmosis presenting as primary adrenal insufficiency in an immunocompetent host in the United States: a case report.
Histoplasma capsulatum is a dimorphic fungus that is mostly seen in immunocompromised individuals. Its presentation ranges from acute pulmonary infections to disseminated disease that can affect multiple organ systems, including the adrenal glands. Dissemination is uncommon in immunocompetent hosts,…
Primary adrenal insufficiency is a rare disease characterized by deficient production of glucocorticoids with or without a deficiency of mineralocorticoids and adrenal androgens.1 This disease can present as a range of symptoms provoking a visit to the emergency department (ED). In this case, we pre…
Frequency of abnormal C-reactive protein concentrations in blood of dogs with hypoadrenocorticism.
C-reactive protein (CRP) concentration in serum or plasma is high in humans during adrenal crisis due to multiple mechanisms, however, the frequency and clinical relevance of high CRP concentrations in dogs with hypoadrenocorticism are unknown. To determine the frequency of high CRP concentrations i…
Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial.
Adrenal insufficiency is conventionally treated with daily multiple-dose hydrocortisone, and once-daily low-dose prednisolone is an alternative for glucocorticoid replacement. Clinical trials comparing once-daily low-dose prednisolone with thrice-daily hydrocortisone are lacking. To examine the diff…
Hypophosphatasia with Coexisting Endocrinopathies: A Diagnostic Dilemma.
Adult-onset hypophosphatasia presents a diagnostic challenge due to confounding clinical and analytical factors. Although rare, the consequence of missed diagnosis is significant, as it can potentiate skeletal mineralization defects. Despite the recent development of diagnostic criteria, integration…
Beyond Malignancy: Clinical Insights from Three Cases of Severe Hypercalcemia.
Severe hypercalcemia is a life-threatening condition requiring immediate treatment alongside a systematic evaluation to identify the underlying cause. Although malignancy is a common etiology among hospitalized patients, alternative causes must be considered to guide targeted therapy, as illustrated…