Evolving role of intestinal ultrasound in the evaluation of Crohn's disease: A clinical- radiological perspective.
This review examines the recent increase in both clinical and radiological interest in ultrasound in inflammatory bowel disease (IBD), with particular emphasis on its role in the assessment of Crohn's disease. Intestinal ultrasound (IUS) has emerged as an attractive imaging modality because of its n…
Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
Clinical and radiologic predictors of one-year surgical outcomes in Crohn's disease-related intra-abdominal abscesses.
To identify clinical and radiological prognostic factors associated with delayed surgery after diagnosis of a Crohn's disease-related intra-abdominal abscess. We conducted a retrospective single-center study including patients with Crohn's disease and confirmed intra-abdominal abscess, managed betwe…
Impact of Crohn's perianal fistulas on healthcare resource utilization: a US chart review study.
Perianal fistulas are a common complication of Crohn's disease. Despite the current treatment options, fistula recurrence/treatment failure rates are high. The aim of this study was to assess healthcare resource utilization (HCRU) among patients with new, persistent, and recurrent Crohn's perianal f…
High thrombin activity associated with crohn's disease induces microbiota pathogenicity contributing to mucosal inflammation.
Thrombin is a serine protease produced by the intestinal epithelium that contributes to mucosal homeostasis by limiting microbial encroachment. In Crohn's disease, mucosal thrombin activity is markedly increased, suggesting a role in disease pathophysiology. We hypothesized that excessive luminal th…
Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.
Flagellin, the structural protein of bacterial flagella, activates the innate immune receptor Toll-like receptor 5 (TLR5). However, the ability of different flagellins to bind and stimulate TLR5 varies widely, suggesting that the composition of an individual's flagellin repertoire, defined as flagel…