Type III interferons attenuates Th1/Th17 cell pathogenicity and regulates retinal pigment epithelium cells via NLRP1/NLRP3 signaling axis in autoimmune uveitis.
Accumulating data implicate Type III interferons (IFN-λs) in autoimmune disorders, prompting our exploration of their role in uveitis pathogenesis. Serum and peripheral blood mononuclear cells (PBMCs) from patients with active Vogt-Koyanagi-Harada (VKH) and active Behçet's disease (BD) we…
Ustekinumab for Intestinal Behçet's Disease: The First Cohort with a Novel Therapy.
Evidence-based treatments for intestinal Behçet's disease (BD) remain limited. There is an unmet need for the development of effective therapies for refractory cases. We aimed to evaluate the safety and efficacy of ustekinumab, an anti-interleukin (IL)-12/23 monoclonal antibody, for intestinal…
Unraveling the psychological burden of Behçet disease: the impact of anxiety and depression on health-related quality of life outcomes.
Behçet's disease (BD) is a chronic, inflammatory multisystem disease that has impact both physical health and mental well-being. However, the psychological impact of BD remains underexplored, particularly in Arabic-speaking populations. The aim of this study was to assess the prevalence of anxi…
Extension of cytokines' role in Behcet's disease associated peripheral neuropathy.
Behçet's disease (BD) is a chronic multisystem inflammatory disorder with diverse neurological manifestations. While central nervous system involvement is well recognized, peripheral neuropathy remains an underdiagnosed and poorly understood complication. Chemokines, particularly C-C motif chem…
Progressive Epiglottic Deformity and Acute Supraglottic Edema: A Fatal Combination in Behçet's Disease.
We report the case of a 36-year-old male patient with an 18-year history of Behçet's disease who was referred to our department in October 2025 for dyspnea and dysphagia. Flexible laryngoscopy revealed a partial epiglottic defect with supraglottic mucosal hyperplasia and edema. Microlaryngoscop…
Mucocutaneous-Predominant Pediatric Behçet's Disease With Recurrent Oral and Genital Ulceration: A Case Report.
A 12-year-old boy presented with recurrent oral and scrotal ulcers, papulopustular lesions, arthralgia, and a positive pathergy test. Autoimmune tests were negative; ophthalmologic and gastrointestinal assessments were reassuring. Topical therapy and colchicine produced sustained improvement. This c…
Serum DNASE1L3 level as a potential exploratory biomarker for Behçet's disease: a preliminary study.
Behçet's disease is a chronic, inflammatory vasculitis affecting multiple systems. In addition to existing laboratory parameters used for the diagnosis and monitoring of Behçet's disease, new biomarkers are needed to improve diagnostic accuracy. The levels and activity of DNASE1L3, an enzy…
Safety and Efficacy of Adalimumab in the Treatment of Refractory Behçet's Uveitis: A Prospective Cohort Study.
Behçet's disease (BD) is a systemic vasculitis characterized by recurrent oral and genital ulcers, skin lesions, and ocular involvement. Uveitis is a major cause of disability and visual loss in BD. This study aimed to evaluate the safety and efficacy of adalimumab in refractory Behçet's u…