White matter microstructural abnormalities in neurological poste-acute sequelae of coronavirus disease: Imaging signatures consistent with persistent neuroinflammation.
Essential workers, many of whom were infected with coronavirus disease (COVID-19) at work before vaccination, developed Neurological Post-Acute Sequelae of COVID-19 (N-PASC) at high rates. To characterize white matter abnormalities associated with N-PASC and to examine correlates of symptomatology,…
Development of the long COVID - 6 dimensions quality of life (LC-6D-QoL) scale: a Delphi study.
Long COVID significantly impairs quality of life through multi-systemic complexity, including fatigue, cognitive dysfunction, and dysautonomia. Existing generic tools fail to capture these manifestations, limiting patient-centered assessment. To address this gap, this study proposed a patient-focuse…
Chronic fatigue syndrome in nursing practice: a concept analysis.
Nurses are essential in chronic fatigue syndrome (CFS) management, serving as care coordinators and patient advocates, but currently lack a unified guiding framework. CFS affects about 0.89% of the global population based on CDC-1994 criteria, with higher prevalence in women. Since its initial defin…
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has sparked a global pandemic with extensive spread, posing a severe threat to public health due to its high mortality rate in severe cases. The continuous emergence of variants with enhanced immune evasion capabilities, coupled with the p…
A mixed-methods study comparing clinical and patient-reported perspectives on long COVID: insights from electronic health records and narrative journal entries.
Many studies of Long COVID have used a variety of clinical and self-reported data to characterize this condition. Previous research has shown the many ways in which these two types of data sources can differ. Our study aims to expand on previous research by exploring descriptions of Long COVID using…
7 Tesla MRI links poorer cognitive function to higher perivascular space burden in neuroPASC.
Post-acute sequalae of SARS-CoV-2 (PASC) are associated with persistent neurological symptoms (neuroPASC). Perivascular spaces (PVS) in the brain may enlarge in the context of inflammation and vascular dysfunction, reflecting impaired glymphatic clearance, and have been linked to cognitive decline.…
[What is the Role of "the Psyche"? Long COVID and ME/CFS as Test Cases for Evidence-Based and Patient-Centered Psychiatry and Psychotherapy].
The role of psychological factors in the development and course of Long Covid (LC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remains a subject of controversial debate. We argue that psychologizing LC and ME/CFS carries significant risks: it leads to potentially harmful therapie…
Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.
Infection-associated chronic illnesses (IACIs) encompass a spectrum of poorly understood syndromes often marked by significant neurologic and multisystem symptoms following an infectious event. This review focuses on several diseases representative of the IACI spectrum. These are post-treatment Lyme…