White matter microstructural abnormalities in neurological poste-acute sequelae of coronavirus disease: Imaging signatures consistent with persistent neuroinflammation.
Essential workers, many of whom were infected with coronavirus disease (COVID-19) at work before vaccination, developed Neurological Post-Acute Sequelae of COVID-19 (N-PASC) at high rates. To characterize white matter abnormalities associated with N-PASC and to examine correlates of symptomatology,…
A narrative review of COVID-19 epidemiology and mRNA vaccine impact in children < 12 years during the omicron era (November 2021 - December 2025).
COVID-19 continues to pose a burden in children under 12 years of age during the Omicron era (November 2021 - December 2025). Following Omicron's emergence, SARS-CoV-2 seroprevalence increased rapidly, with most children infected by ages 2-4 years. Pediatric hospitalization rates decli…
Metformin on the Presence of COVID-19 Symptoms 6 Months after Infection: The ACTIV-6 Randomized Clinical Trial.
We conducted a quadruple-blinded, randomized, placebo-controlled trial of metformin for treating acute SARS-CoV-2 infection to prevent long COVID symptoms in low-risk adults. The ACTIV-6 platform evaluated repurposed medications for mild to moderate COVID-19. Between September 19, 2023 and May 1, 20…
Clinician perspectives on Long-COVID physical rehabilitation: challenges, uncertainty, and semantics.
To understand the perspectives of clinicians who provided rehabilitation services to people with Long-COVID or referred people to such services. Clinicians involved with Long-COVID rehabilitation were recruited via email and interviewed. Recruitment continued until thematic saturation on physical re…
Impact of long COVID on health-related quality-of-life among Japanese adults: findings of CARE Japan study.
This study aimed to comprehensively assess the implications of long COVID on the health-related quality-of-life (HRQoL) among Japanese adults and to identify its associated factors. This study used prospective cohort data from the CARE Japan Study between January 2022 and January 2023. The outcome o…
Inflammatory biomarkers in the assessment of kidney function decline in Long Covid syndrome.
Long Covid (LC) is an inflammatory condition, affecting multiple organs, including kidneys. This study aims to identify a signature of inflammatory biomarkers that can predict, describe, and monitor kidney function decline in LC patients. A single-center observational study was carried out at the CO…
Exploring the implementation of a long COVID rehabilitation intervention: a mixed-methods process evaluation.
Long COVID is recognised as a global public health concern, creating demand for rehabilitation. Despite a growing evidence base on long COVID rehabilitation interventions, knowledge of the implementation of these interventions remains limited, constraining adaptation and transfer across health care…
Assessing income heterogeneity of female sex as risk factor for long COVID: a meta-analytic investigation.
Women have a higher risk of Long COVID, defined as symptoms persisting for three or more months after SARS-CoV-2 infection. This study examines whether the elevated risk of Long COVID among women varies across income subgroups in a nationally representative sample of the U.S. population. Using data…