Functional neurological disorder: characterization, diagnosis, and outcome predictors in a Brazilian cohort.
Functional neurological disorder (FND) is a prevalent, disabling neuropsychiatric condition recognized as a distinct clinical entity characterized by positive neurological signs. Despite growing international research, Brazilian data on this disoder remain scarce and predictors of clinical outcomes…
Astrocytic 4R-tau pathology drives aquaporin-4 (AQP4) mislocalization, glymphatic dysfunction, and neurotransmitter dysregulation in mice.
Progressive supranuclear palsy (PSP) is a severe neurodegenerative tauopathy defined by astrocytic tau inclusions and parkinsonism. The link between astrogliopathy and compromised cerebral fluid dynamics remains unclear. We generated a glial fibrillary acidic protein (GFAP)-e (2A-mMAPT(4R) cDNA) tra…
Positive Clinical Signs of Functional Neurological Disorders Are Found in Patients With Functional Cognitive Disorders.
The proposition of diagnostic criteria of functional cognitive impairment (FCD) is relatively recent, includes different subtypes of heterogenous aetiologies, and likely involves underlying mechanisms similar to those found in functional neurological disorders (FNDs). The present study aims at descr…
Repetitive transcranial magnetic stimulation in functional motor disorders: A systematic review of effects and targets.
To evaluate the effectiveness, safety, and potential mechanistic implications of repetitive transcranial magnetic stimulation (rTMS) in adults with functional motor disorders (FMD), focusing on possible phenotype-specific responses and stimulation protocols. Seven databases were searched from incept…
Functional neurological disorder is associated with postoperative complications after ACDF: a retrospective propensity-matched analysis.
Psychiatric comorbidities are associated with worse postoperative outcomes after cervical spine surgery, yet the impact of Functional Neurological Disorder (FND), a neuropsychiatric condition characterized by involuntary neurologic symptoms, has not been investigated. The objective of this study was…
Association between Corticosteroids and In-Hospital Mortality After Cardiac Arrest: A Multicenter Study Using the eICU Collaborative Research Database.
Clinical outcomes following cardiac arrest remain poor, and the therapeutic value of corticosteroids is controversial. We investigated the association between corticosteroid administration and in-hospital mortality across clinical phenotypes. Using the eICU Collaborative Research Database, we includ…
Treatment engagement and 12-month outcomes after diagnostic communication and individualized treatment planning in patients with functional neurological disorder.
To evaluate treatment engagement and 12-month outcomes following structured diagnostic communication and individualized treatment planning in inpatients with the most common functional neurological disorder (FND) presentations encountered in epilepsy services and to explore the relationship between…
Targeting BCAA/PPAR-γ Axis with Pioglitazone Reverses Insulin Resistance and Mitigates Post-Cardiac Arrest Injury.
Metabolic dysfunction contributes to poor outcomes after cardiac arrest (CA). Conventional intensive glucose control fails to improve neurological recovery, and the underlying mechanism remains unclear. We aimed to explore whether insulin resistance (IR) induced by dysregulated branched-chain amino…