What helps? Patient-reported strategies for managing functional/dissociative seizures: a cross-sectional survey.
The value of incorporating lived experience into research is increasingly recognised, however, traditional functional/dissociative seizure (FDS) treatment studies assess treatment efficacy prior to ascertaining real-world effectiveness. This study aimed to gather firsthand accounts from individuals…
Surgical Management of Spinal Chondrosarcoma: Retrospective Case Series and Systematic Review of the Literature.
Spinal chondrosarcomas are locally aggressive primary malignant tumors that are often resistant to chemotherapy and radiation. Wide surgical resection with negative margins remains the cornerstone of treatment. We present our institutional experience and review the literature regarding outcomes afte…
Challenges in the diagnosis and management of functional movement disorders in a developing nation: insights from the Philippines.
Functional movement disorders (FMDs) are common but often misdiagnosed among functional neurological disorders. Key findings from this study include frequent diagnostic delays, a predominance of women (70% of cases), and frequent comorbidity with anxiety and mood disorders. Tremor and dystonia were…
Functional neurological disorder (FND) is characterised by disabling motor, sensory and/or seizure symptoms. Contemporary models highlight the possible involvement of altered affective and autonomic regulation and interoceptive processing in FND. However, accessible, mechanism-informed interventions…
[Stiff-person syndrome; the diagnostic challenges of a treatable condition].
Stiff-person syndrome (SPS) is a rare immune-mediated neurological condition, characterized by ambulatory problems and falls, muscle hypertonia and spasms, and debilitating task-specific phobias. The diagnostic delay is often significant due to physicians not recognizing SPS and due to misdiagnoses…
Hierarchical piezoelectric conduit coordinates bioelectric cues and microRNA regulation for functional neurological regeneration.
Current clinical interventions for critical-sized nerve defects face dual challenges of inadequate microenvironmental guidance and passive regenerative response in synthetic neural interfaces. We present an electrotopographic nerve guidance conduit with triaxial architectural hierarchy that actively…
Pain in Functional Motor Disorders: Clinical Correlates From the Italian Registry.
Pain is a frequent and disabling symptom in patients with Functional Motor Disorders (FMD), yet its clinical correlates and impact have not been characterized in large, representative cohorts. The aims of this study were to identify clinical predictors and correlates of pain intensity and interferen…
Disability, distress and delayed access to care in functional neurological disorder: cross-sectional study from an Australian tertiary clinic.
Functional neurological disorder (FND) is a common condition, but there remain substantial gaps in our understanding of its effects, particularly on severity of disability and health status. To characterise disability, quality of life and psychological and somatic symptom comorbidity in individuals…