Hereditary Angioedema

Response to reader comments on "clinical features of Hereditary Angioedema involving the gastrointestinal tract: A retrospective analysis".

Limited access to on-demand treatment in hereditary angioedema is linked to delayed treatment and impaired patient-reported outcomes: A multinational real-world study.

Hereditary angioedema (HAE) is a rare inherited disorder characterized by recurrent episodes of soft tissue swelling. Disparities in HAE care have been described in Asia, Africa, and South America. Less is known about how patients in these regions experience and respond to these limitations. Our aim…

Dengue haemorrhagic fever complicated with intravascular haemolysis, coagulopathy and haemophagocytic lymphohistiocytosis: a case report.

Dengue haemorrhagic fever (DHF) may occasionally manifest with atypical or severe complications under the umbrella of expanded dengue syndrome (EDS). Haemophagocytic lymphohistiocytosis (HLH) and intravascular haemolysis are rare but potentially fatal complications that require a high index of suspi…

Analysis of adverse events following COVID-19 vaccination and infection: A retrospective, comparative cohort study using a claims database from Discovery Health, a managed care organisation in South Africa.

Adverse events following COVID-19 vaccination have been studied extensively in recent years. However, there remains a paucity of data directly comparing adverse events among COVID-19 vaccinees and individuals with SARS-CoV-2 infection within the insured population in South Africa (SA). Moreover, the…

Population Pharmacokinetics of Oral Gecacitinib in Healthy Subjects and Patients with Autoimmune and Inflammatory Diseases.

Gecacitinib is a novel, broad-spectrum Janus kinase (JAK) inhibitor being developed for the treatment of myelofibrosis, severe alopecia areata, ankylosing spondylitis, and atopic dermatitis. This study aimed to develop population pharmacokinetic (PopPK) models for gecacitinib and its metabolites ZG0…

Concurrent hereditary angioedema type I and common variable immunodeficiency presenting as suspected antibiotic hypersensitivity: Case report and literature discussion.

Hereditary angioedema (HAE) and common variable immunodeficiency (CVID) are rare disorders with heterogeneous clinical presentations that pose significant diagnostic challenges. HAE is characterized by recurrent episodes of subcutaneous or submucosal edema affecting the skin, gastrointestinal tract,…

FXII Frameshift Variant Does Not Cause Hereditary Angioedema with Normal C1 Inhibitor.

Diagnostic challenge in primary angiitis of the central nervous system: altered consciousness with multifocal infarcts and haemorrhages.

We present the case of a man in his late 50s who was admitted with an acute ischaemic stroke and subsequently developed rapidly progressive encephalopathy, multiple bilateral infarcts and intracranial haemorrhages. Despite initial suspicion of reversible cerebral vasoconstriction syndrome or posteri…