Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.
Medical devices have revolutionized patient care; however, their abiotic surfaces remain highly susceptible to bacterial biofilm formation, enabling immune evasion and antibiotic resistance. Although antibacterial coatings can mitigate bacterial colonization, many rely on antimicrobial agents that m…
Improving capability, opportunity and motivation to support hereditary angioedema patients experiencing life threatening attacks: Pilot evaluation of a video-based training tool for healthcare professionals.
Hereditary angioedema (HAE) is a rare inherited illness which causes swelling and can be life-threatening without urgent treatment. Patients who experience life-threatening throat swellings report poor emergency care experiences and long-term psychological distress from these encounters. A >&#x…
Diagnostic efficacy of pan-immune inflammation value for ulcerative colitis activity: a study based on multi-indicator comparison and diagnostic grey zone validation.
Faecal calprotectin (FC) has limitations including inconvenient sampling and limited accessibility, while several blood markers derived from complete blood counts demonstrate suboptimal diagnostic performance in monitoring ulcerative colitis (UC) disease activity. There is an urgent need for superio…
Pseudo-Addisonian Crisis With Hyponatremia and Hyperkalaemia in a Late Pregnant Bitch.
A 3-year-old pregnant Golden Retriever bitch was presented 52 days after ovulation for nausea, hyporexia, regurgitation, polyuria, and polydipsia. Reproductive ultrasound demonstrated several viable foetuses, and the bitch was treated conservatively. Two days later, the bitch was hospitalized due to…
Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.
Cholangiocarcinoma (CCA) is a common and highly refractory malignancy; however, biomarkers and therapeutic targets associated with its progression remain incompletely understood. Crotonylation is an emerging lysine acylation modification that has been implicated in multiple diseases. In this study,…
A case of immune thrombocytopenia complicated by catastrophic antiphospholipid antibody syndrome and subsequent intramuscular haemorrhage.
Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) are autoimmune disorders that may coexist, creating a challenging clinical scenario characterised by bleeding risk alongside paradoxically increased thrombotic risk. Catastrophic antiphospholipid syndrome (CAPS) is a rare but life-thr…
Living-Donor Kidney Transplantation Between Mother and Son With Clinically Confirmed Hereditary Angioedema.
Hereditary angioedema (HAE) is a rare autosomal dominant disorder resulting from SERPING1-related C1-inhibitor deficiency. Surgical stress and airway manipulation may precipitate life-threatening attacks. Experience with kidney transplantation in patients with HAE remains extremely limited. We descr…
Ex vivo bradykinin as a functional biomarker for angioedema with normal C1-inhibitor.
Bradykinin-mediated angioedema (AE-BK) remains diagnostically challenging particularly in patients with normal C1-inhibitor, where diagnosis primarily relies on clinical criteria. Routine laboratory tests can identify complement deficiency in hereditary angioedema due to C1-inhibitor deficiency (HAE…