Analytical evaluation and method comparison of an orexin-A radioimmunoassay in cerebrospinal fluid: establishing a cut-off value for type 1 narcolepsy and exploring genetic and clinical characteristics.
This study aimed to evaluate an in-house radioimmunoassay (RIA) for cerebrospinal fluid (CSF) orexin-A measurement, establish a diagnostic cut-off for narcolepsy type 1 (NT1), explore associations with HLA genotype, assess the significance of intermediate orexin-A levels, and compare post-H1N1 Pande…
A multidisciplinary biopsychosocial approach reveals behavioural phenotypes in idiopathic hypersomnia: a prospective single-arm study.
Idiopathic hypersomnia (IH) is clinically heterogeneous yet defined almost entirely in electrophysiological terms, and pharmacotherapy frequently fails to restore daytime functioning. We asked whether IH heterogeneity extends to stable behavioural phenotypes and whether an individualised, multidisci…
Sleep-disordered breathing and psychiatric comorbidities in narcolepsy: A 10-year retrospective study from Saudi Arabia.
Narcolepsy is a chronic disorder of central hypersomnia that is frequently under-recognized. Diagnostic delay, comorbid sleep-disordered breathing (SDB), and psychiatric comorbidities are well described internationally but remain poorly characterized in Saudi Arabia. We retrospectively reviewed all…
The German version of the Sleep Inertia Questionnaire in central disorders of hypersomnolence: a validation study.
Sleep inertia, or sleep drunkenness, is a transitional state between sleep and wakefulness characterized by cognitive and physical impairment. It is particularly relevant in central disorders of hypersomnolence (CDH), but validated instruments to assess sleep inertia in German-speaking populations a…
Preceding night sleep time and multiple sleep latency test outcomes.
Evidence supporting how much sleep the night before a multiple sleep latency test (MSLT) is required to generate valid results is lacking. We evaluated the association between preceding night total sleep time (TST) and next-day MSLT outcomes. We retrospectively analyzed MSLT and preceding overnight…
Post-Nap Sleep Inertia in Narcolepsy Type 1 and Idiopathic Hypersomnia.
To compare post-nap sleep inertia between patients with idiopathic hypersomnia (IH) and narcolepsy type 1 (NT1) by assessing changes in subjective sleepiness and objective performance. In 128 drug-free patients (50 IH, 78 NT1), standardized overnight polysomnography and Multiple Sleep Latency Testin…
Narcolepsy and Idiopathic Hypersomnia Real-World Treatment Patterns and Changes in Alerting Agent Use After Low-Sodium Oxybate Initiation: A Retrospective Claims Analysis.
Various medications are prescribed to treat narcolepsy and idiopathic hypersomnia (IH), including low-sodium oxybate (LXB) and alerting agents (AAs; i.e., stimulants and wake-promoting agents). This study assessed treatment patterns in individuals with narcolepsy/IH, as well as changes in AA utiliza…
Socioeconomic impact of central disorders of hypersomnolence: A national register-based case-control study.
Several studies have examined the disease burden of narcolepsy type 1 (NT1). However, comprehensive comparisons of disease impact across NT1, narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH) are lacking. In this single-center retrospective matched case-control study, 433 patients with a cent…