Analytical evaluation and method comparison of an orexin-A radioimmunoassay in cerebrospinal fluid: establishing a cut-off value for type 1 narcolepsy and exploring genetic and clinical characteristics.
This study aimed to evaluate an in-house radioimmunoassay (RIA) for cerebrospinal fluid (CSF) orexin-A measurement, establish a diagnostic cut-off for narcolepsy type 1 (NT1), explore associations with HLA genotype, assess the significance of intermediate orexin-A levels, and compare post-H1N1 Pande…
Sleep-disordered breathing and psychiatric comorbidities in narcolepsy: A 10-year retrospective study from Saudi Arabia.
Narcolepsy is a chronic disorder of central hypersomnia that is frequently under-recognized. Diagnostic delay, comorbid sleep-disordered breathing (SDB), and psychiatric comorbidities are well described internationally but remain poorly characterized in Saudi Arabia. We retrospectively reviewed all…
The German version of the Sleep Inertia Questionnaire in central disorders of hypersomnolence: a validation study.
Sleep inertia, or sleep drunkenness, is a transitional state between sleep and wakefulness characterized by cognitive and physical impairment. It is particularly relevant in central disorders of hypersomnolence (CDH), but validated instruments to assess sleep inertia in German-speaking populations a…
Preceding night sleep time and multiple sleep latency test outcomes.
Evidence supporting how much sleep the night before a multiple sleep latency test (MSLT) is required to generate valid results is lacking. We evaluated the association between preceding night total sleep time (TST) and next-day MSLT outcomes. We retrospectively analyzed MSLT and preceding overnight…
Sodium oxybate for excessive daytime sleepiness in narcolepsy: a systematic review and meta-analysis of randomized placebo-controlled trials.
Excessive daytime sleepiness (EDS) is a debilitating symptom in narcolepsy. Sodium oxybate (SO) is approved for narcolepsy and has shown consistent efficacy across multiple formulations. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of SO compared to placebo in r…
Post-Nap Sleep Inertia in Narcolepsy Type 1 and Idiopathic Hypersomnia.
To compare post-nap sleep inertia between patients with idiopathic hypersomnia (IH) and narcolepsy type 1 (NT1) by assessing changes in subjective sleepiness and objective performance. In 128 drug-free patients (50 IH, 78 NT1), standardized overnight polysomnography and Multiple Sleep Latency Testin…
The sleep EEG spectral profile of narcolepsy with comorbid obstructive sleep apnea more closely resembles narcolepsy than obstructive sleep apnea.
Narcolepsy (NT) and obstructive sleep apnea (OSA) frequently coexist, yet the sleep electroencephalographic (EEG) spectral profile of narcolepsy with comorbid OSA (NT-OSA) remains unclear. We compared spectral power among NT-OSA, NT, and OSA across polysomnography (PSG) and Multiple Sleep Latency Te…
A retrospective exploratory study of sleep spindles as an adjunctive diagnostic marker for narcolepsy type 1: a comparison with insufficient sleep syndrome.
Narcolepsy type 1 (NT1) and insufficient sleep syndrome (ISS) both present with excessive daytime sleepiness (EDS) and may fulfill the diagnostic criteria on the multiple sleep latency test (MSLT); therefore, differential diagnosis is often difficult. This study examined whether sleep spindle (SS) i…