Regulatory effects of leflunomide on gut microecology during IgA nephropathy treatment.
Growing evidence suggests that the gut-kidney axis may contribute to the pathogenesis of IgA nephropathy (IgAN). However, the effects of immunosuppressants on the intestinal microbiome remain unclear. We investigated how different therapeutic strategies influence gut microbial composition in IgAN pa…
The relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and tubular atrophy/interstitial fibrosis in patients with IgA nephropathy.
Background: The tubular atrophy/interstitial fibrosis (T) lesions of the Oxford Classification is a key prognostic determinant in IgA nephropathy (IgAN). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an emerging lipid marker, but its link with r…
The successful use of rituximab in children with IgA nephropathy and minimal change-like lesions: a case series.
IgA nephropathy with minimal change disease (IgAN-MCD) is a rare glomerulopathy combining features of both entities, typically presenting as steroid-sensitive nephrotic syndrome (NS) with frequent relapses. While rituximab (RTX) is commonly used in pediatric glomerular diseases, its efficacy in IgAN…
Clinical significance of serum complement levels and C3/C4 ratio in IgA nephropathy: histopathological correlates and prognostic implications.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Complement activation plays a central role in its pathogenesis; however, the prognostic significance of serum complement levels remains unclear. In this single-center retrospective study, we evaluated the pr…
Atypical Wiskott-Aldrich syndrome presenting with normal platelet volume and end-stage renal disease: from misdiagnosis as ITP to combined transplantation.
We report a 30-year-old male with a novel WAS mutation (c.252C > A, p.F84L) who was misdiagnosed with immune thrombocytopenia (ITP) for years. Despite persistent thrombocytopenia, his mean platelet volume remained normal, an atypical feature of Wiskott-Aldrich syndrome (WAS). His cours…
Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.
The role of homocysteine (Hcy) in immunoglobulin A nephropathy (IgAN) remains unclear. This study investigates the association between Hcy levels, clinical symptoms, and pathological changes in patients with IgAN to elucidate Hcy's clinical significance. 256 IgAN patients were included and categoriz…
Research on the safety and efficacy of telitacicept in the treatment of IgA nephropathy in children.
This study retrospectively evaluated telitacicept in ten pediatric IgA nephropathy patients with proteinuria (24-hour urinary protein: 23.97 ± 26.63 mg/kg). All patients received steroid therapy, and half received combined immunosuppressants. After a median follow-up of 3.7…
Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects.
Podocyte injury serves as a central pathological driver in chronic kidney diseases (CKD), including diabetic kidney disease (DKD) and IgA nephropathy (IgAN). However, conventional therapies are still limited by poor targeting efficacy and systemic side effects. Nanotechnology provides transformative…