Low-density granulocyte-driven NET formation is associated with poor prognosis in IgA nephropathy with thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) is a common pathological phenotype of immunoglobulin A nephropathy (IgAN). Low-density granulocytes (LDGs) exhibit potent pro-inflammatory properties and promote neutrophil extracellular trap (NET) formation, playing a pivotal role in thrombus development. This study…
Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects.
Podocyte injury serves as a central pathological driver in chronic kidney diseases (CKD), including diabetic kidney disease (DKD) and IgA nephropathy (IgAN). However, conventional therapies are still limited by poor targeting efficacy and systemic side effects. Nanotechnology provides transformative…
Clinical Features and Outcomes of Recurrent IgA Nephropathy After Transplantation: A Case Series and Comparison to Native Disease.
Recurrent IgA nephropathy (rIgAN) after kidney transplantation threatens long-term graft survival, yet contemporary clinicopathological descriptions are limited. We describe clinical, histological, and outcome features of rIgAN and compare them with native IgAN (nIgAN) in a single-center retrospecti…
Large vessel vasculopathy: An underrecognized complication in Wiskott-Aldrich syndrome.
Autoimmune manifestations occur in 25-75% of patients with Wiskott-Aldrich syndrome (WAS), commonly including autoimmune hemolytic anemia, skin vasculitis, IgA nephropathy, arthritis, and inflammatory bowel disease. Large vessel vasculopathy is rarely reported in WAS. We present a review of children…
Gut Virome Characteristics and Network Alterations in IgA Nephropathy.
Emerging evidence implicates gut microbiota dysbiosis in the pathogenesis of IgA nephropathy (IgAN), yet the contribution of the gut virome remains unexplored. This study aimed to characterize virome signatures and virus-microbiota interactions in IgAN. We performed a rigorously matched case-control…
JAK Inhibitor-Induced Improvement of IgA Nephropathy in a Patient With Polycythemia Vera: A Case Report.
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by the clonal expansion of hematopoietic stem cells, commonly caused by pathogenic variants in Janus kinase 2 (JAK2). Although PV primarily affects the hematologic system, various renal manifestations have been reported, including…
FMultifunctional magnetic resonance imaging for the assessment of renal pathological alterations in IgA nephropathy.
We aimed to evaluate the application value of multiparametric diffusion weighted magnetic resonance imaging (MRI) for the assessment and risk stratification of renal histopathological injuries in patients with IgA nephropathy (IgAN), as an exploratory study. 95 patients were prospectively enrolled,…