Low-density granulocyte-driven NET formation is associated with poor prognosis in IgA nephropathy with thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) is a common pathological phenotype of immunoglobulin A nephropathy (IgAN). Low-density granulocytes (LDGs) exhibit potent pro-inflammatory properties and promote neutrophil extracellular trap (NET) formation, playing a pivotal role in thrombus development. This study…
Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects.
Podocyte injury serves as a central pathological driver in chronic kidney diseases (CKD), including diabetic kidney disease (DKD) and IgA nephropathy (IgAN). However, conventional therapies are still limited by poor targeting efficacy and systemic side effects. Nanotechnology provides transformative…
Beyond galactose-deficient IgA1: reconsidering IgA2 as a pathogenic driver in IgA nephropathy.
IgA nephropathy (IgAN) has long been viewed as a disease driven almost exclusively by IgA1, in particular galactose-deficient IgA1. However, emerging evidence challenges this IgA1-centric paradigm. In this issue of Kidney International, Li et al. demonstrate that IgA2 is consistently deposited in Ig…
Living Donor Kidney Transplantation in High-Recurrence Kidney Diseases: Precision Risk Stratification and Management.
Living-donor kidney transplantation (KT) offers the best outcomes for patients with kidney failure (KF). However, recurrence of primary kidney disease in the allograft remains a major concern and represents 1 of the leading causes of graft loss, significantly influencing donor and recipient selectio…
Telitacicept for refractory IgA nephropathy: a case series.
IgA nephropathy (IgAN) is characterized by the mesangial deposition of IgA. Its pathogenesis is driven by increased production of galactose-deficient IgA1 (Gd-IgA1) by activated B cells. Telitacicept offers a therapeutic approach for IgAN by inhibiting B-cell activation. This study aimed to investig…
Anti-glomerular basement membrane disease: variant forms and underlying mechanisms.
Anti-glomerular basement membrane (GBM) disease is the most severe form of autoimmune glomerulonephritis following assaults on kidney and alveolar basement membranes by pathogenic anti-GBM antibodies. Typically, anti-GBM disease is characterized by rapidly progressive glomerulonephritis and an incre…
Therapeutic Efficacy and Antigenicity of a Novel PEGylated IgA Protease in Preclinical Models of IgA Nephropathy.
IgA nephropathy is the most common primary glomerulonephritis worldwide, characterized by IgA deposition and a high risk of progression to kidney failure. While emerging therapies target IgA production or downstream inflammation, strategies to directly clear established IgA deposits from the kidney…
Apoptosis Inhibitor of Macrophage and Acute Inflammation in IgA Nephropathy.
IgA nephropathy is characterized by mesangial deposits of IgA1-containing immune complex with complement 3 (C3). Our previous study demonstrated that apoptosis inhibitor of macrophage (AIM) plays a critical role in in situ IgA-containing immune complex formation and subsequent complement activation…