Artificial intelligence-powered renal pathology for glomerular disease classification: a systematic review and meta-analysis.
Diagnostic performance varies across glomerular disease (GD) subtypes, and whether artificial intelligence (AI) outperforms pathologists with different experience levels remains uncertain. To evaluate pathology-based AI models for GD classification and compare their performance with pathologists. Pu…
Microplastics and IgA nephropathy: a novel environmental hypothesis of immune dysregulation.
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by a 4-hit pathogenesis primarily driven by mucosal immune dysregulation in the gut-associated lymphoid tissue (GALT). However, the specific environmental triggers initiating this cascade remain elusive. We propose…
Kidney biopsy in patients with small kidneys: diagnostic yield and treatment modification in a retrospective cohort study.
Reduced renal size has traditionally been considered a relative contraindication to kidney biopsy because of the perception that advanced chronic damage provides limited diagnostic or therapeutic benefit. However, the actual clinical value of renal biopsy in patients with small kidneys remains insuf…
Smoking exposure and long-term progression of IgA nephropathy: a retrospective cohort study of 9,560 patients.
Although cigarette smoking is an exposure associated with chronic kidney disease, its role in the progression of IgA nephropathy (IgAN) remains not well defined. We investigated the association between smoking exposure and adverse kidney outcomes in a large Chinese cohort of patients with IgAN. This…
Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease.
This study characterized clinical features, pathology, treatment, and prognosis of biopsy-confirmed coexisting IgA nephropathy (IgAN) and diabetic kidney disease (DKD). This single-centre retrospective study included 80 patients with biopsy-proven IgAN + DKD (2010-2023). Propensity score m…
Efficacy and safety of finerenone in adults with IgA nephropathy: a 12-month real-world study.
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a leading cause of end-stage renal disease. Finerenone reduces proteinuria in diabetic kidney disease, but evidence in IgAN remains limited. This single-center retrospective study included adults with biopsy-proven Ig…
Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen.
The long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases. Genetic variants associated with four surgery-related phenotypes-…
Clinical and pathological factors associated with eGFR slope in IgA nephropathy: a single-center retrospective cohort study.
IgA nephropathy (IgAN) has a heterogeneous clinical course. We retrospectively studied 180 patients with biopsy-proven IgAN and at least 3 years of clinical follow-up. Patient-specific eGFR slopes were estimated from available measurements at biopsy and the 6-, 12-, 18-, 24-, 30-, and 36-mont…