Long-term outcomes of splanchnic radiofrequency ablation for control of chronic abdominal visceral, non-malignant pain.
Splanchnic radiofrequency ablation (RFA) is an effective therapy for the treatment of severe abdominal pain. Although it was first described almost 25 years ago, long-term data on longevity and effectiveness are still lacking. Here, we describe the long-term outcomes of a larger retrospective cohort…
Novel treatment of celiac trunk and proximal splenic artery aneurysms in vascular Ehlers-Danlos patient with combined Onyx and coil embolization.
Vascular Ehlers-Danlos syndrome is associated with severe arterial fragility and life-threatening visceral complications. We report a 30-year-old woman with genetically confirmed vascular Ehlers-Danlos syndrome who presented with abdominal pain, nausea, and emesis. Persistent symptoms prompted seria…
Primary pancreatic squamous cell carcinoma with duodenal invasion: Literature review and a case report.
Pancreatic squamous cell carcinoma (PSCC) is a rare pancreatic exocrine tumor. Pancreas does not contain squamous cells, which further makes it a rare tumor. However, several theories have explained histogenesis and mechanism of carcinogenesis. PSCC is very rare, has a poor prognosis and an aggressi…
A bilobed syphilitic thoracoabdominal aortic aneurysm with vertebral erosion and multibranch visceral occlusion.
A 55-year-old man with serologically confirmed tertiary syphilis had an asymptomatic 70 mm bilobed thoracoabdominal aortic aneurysm with two contiguous saccular components, severe T11 to T12 vertebral body erosion, complete celiac artery occlusion, and critical ostial stenosis of the superior mesent…
Staged surgical management of multiple arterial aneurysms in aneurysms osteoarthritis syndrome with a novel SMAD3 mutation.
We report the case of a 33-year-old man diagnosed with aneurysms-osteoarthritis syndrome due to a novel SMAD3 mutation (c.864_870dup). The patient exhibited epigastric pain, severe pectus excavatum, and multiple arterial aneurysms. Genetic testing and vascular imaging supported the diagnosis. Surgic…
Molecular histomorphometry and the emerging role of transcriptomics in celiac disease diagnosis and therapeutic trials.
Celiac disease (CeD) is an autoimmune enteropathy in which diagnosis and disease monitoring rely on serology and small-intestinal histology. However, conventional histological assessment is semi-quantitative, subject to interobserver variability, and relatively insensitive to subtle mucosal changes,…
Next-generation immunoassays for autoantibody detection in celiac disease: emerging technologies and diagnostic advances.
The appearance of disease‑specific autoantibodies (Aab) is a hallmark of celiac disease (CeD). The recent adaption of a no‑biopsy approach places greater reliance on Aab testing. Despite their widespread use, conventional assay formats such as enzyme-linked immunosorbent assays (ELISA)…
Linkage between HLA-B8 and HLA-DQ2.5 contributes to ancestry-dependent risk for celiac disease.
Limited genetic studies on celiac disease (CeD) are available for the Hispanic and black populations. We identified 3,481 individuals with CeD from the All of Us Research Program. Of these, 2,899 carried one of the four well-established risk haplotypes, including 262 of admixed American (89% Hispani…