Next-generation immunoassays for autoantibody detection in celiac disease: emerging technologies and diagnostic advances.
The appearance of disease‑specific autoantibodies (Aab) is a hallmark of celiac disease (CeD). The recent adaption of a no‑biopsy approach places greater reliance on Aab testing. Despite their widespread use, conventional assay formats such as enzyme-linked immunosorbent assays (ELISA)…
The clinical utility of exome sequencing for risk stratification in celiac disease.
The potential utility of genetic testing among individuals with a positive celiac disease (CeD) family history remains limited. We performed whole-exome sequencing in a cohort of 107 cases with CeD and 117 unaffected relatives from 66 families. We assessed fourteen HLA-DQ genotypes, based on combina…
Temperature and raw material impact on gluten digestibility and immunoreactive peptides in wheat, rye, and barley.
Peptides released from gluten proteins during gastrointestinal digestion can trigger various wheat-related disorders, including celiac disease (CeD), wheat allergy, and wheat allergy dependent on augmentation factors (WALDA). Our study aimed to identify and quantify these immunoreactive peptides (IP…
Characterization of visceral branch geometry in a four-branch off-the-shelf device for endovascular repair of paravisceral and thoracoabdominal aortic aneurysms.
This study aims to evaluate visceral branch geometry, including angulation, tortuosity, and diameter, of the GORE EXCLUDER thoracoabdominal branch endoprosthesis (TAMBE) in real-world utilization. All patients were identified and treated with TAMBE from June 2024 to June 2025 at a single institution…
Complete false lumen exclusion by superior mesenteric artery revascularization with balloon angioplasty and bridging stent grafting followed by thoracic endovascular aortic repair in a patient with complex chronic type B aortic dissection.
Endovascular exclusion of the false lumen (FL) in chronic type B aortic dissection is challenging when visceral branches depend on FL perfusion. We report a case of chronic type B aortic dissection in which the superior mesenteric artery (SMA) originated from the FL with concomitant celiac artery oc…
Gangrenous cholecystitis as a sentinel manifestation of chronic mesenteric ischemia in a hepatomesenteric trunk.
Chronic mesenteric ischemia is an uncommon and often underdiagnosed atherosclerotic condition due to nonspecific symptoms. The hepatomesenteric trunk is a rare anatomical variant with important clinical implications when its common origin is involved. We report the case of a 43-year-old heavy smoker…
Stepwise management of median arcuate ligament syndrome with visceral artery aneurysm: Surgical ligament release followed by percutaneous transluminal angioplasty.
A woman in her 20s presented with an 8-year history of postprandial abdominal pain. Contrast-enhanced computed tomography revealed severe stenosis at the origin of the celiac artery, collateral circulation from the superior mesenteric artery, and an associated inferior pancreaticoduodenal artery ane…
Inherited Predisposition to Increased Systemic Inflammation Predicts a Broad Class of Disease Phenotypes.
Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the…