Phenotype, Severity, and Therapy of Patients With LRP4 Antibody-Associated Myasthenia Gravis in the German Myasthenia Gravis Registry.
Lipoprotein receptor-related protein 4 antibody-positive myasthenia gravis (LRP4-Ab-positive MG) is a rare serologic subgroup with poorly defined clinical phenotype. This study investigated demographics, clinical features, treatments, and disease burden of LRP4-Ab-positive MG against other antibody-…
Environmental assessment of magnetic and elemental characteristics of coal and combustion ashes collected from the Cuddalore Thermal Power Plant, India.
This study investigates the magnetic properties, elemental composition, and surface morphology of coal, fly ash, and bottom ash samples collected from the Cuddalore Thermal Power Plant area. Magnetic susceptibility measurements reveal that lignite coal exhibits paramagnetic to weak ferrimagnetic beh…
miR-6836-5p Drives Astrocyte Pro-survival Signaling Through DLG2-Hippo-YAP Pathway Under AQP4-IgG + ve NMOSD Stress.
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy mainly driven by serum antibodies against aquaporin-4 (AQP4-IgG). While antibody-mediated injury to astrocytes is well documented, the intrinsic cellular responses that influence astrocyte survival under such stress remai…
Urinary Dysfunction in Myasthenic Syndromes: A Scoping Review of Clinical Features and Treatment-Related Associations.
Urinary dysfunction has been reported in association with myasthenic syndromes, including myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital myasthenic syndromes (CMS), but evidence regarding its prevalence, clinical impact, pathophysiology, and management remains limit…
Direct 1H-qNMR quantification of massoia lactone in endophytic Neocosmospora solani extracts and correlation with antifungal activity.
Quantitative analysis of metabolites in complex fungal extracts remains challenging due to the limited availability of authentic standards. In this work, a 1H quantitative nuclear magnetic resonance (qNMR) method was developed for the direct quantification of massoia lactone in crude extracts of the…
Thymectomy promotes maintained complete stable remission in myasthenia gravis.
This study aimed to evaluate the impact of thymectomy on the long-term prognosis of myasthenia gravis (MG) patients, using maintainable complete stable remission (mCSR) as the primary outcome. We performed a retrospective analysis of prospectively collected data from the MG database at West China Ho…
Real-World vs. Randomized Trial Evidence for Incretin-Based Therapies: A Narrative Review.
Incretin-based therapies have transformed the management of obesity and type 2 diabetes (T2D). Pivotal randomized controlled trials (RCTs) report substantial weight loss and glycemic improvements; the extent to which these translate to clinical populations remains uncertain. Seven 2026-published RCT…
Living-Donor Kidney Transplantation Between Mother and Son With Clinically Confirmed Hereditary Angioedema.
Hereditary angioedema (HAE) is a rare autosomal dominant disorder resulting from SERPING1-related C1-inhibitor deficiency. Surgical stress and airway manipulation may precipitate life-threatening attacks. Experience with kidney transplantation in patients with HAE remains extremely limited. We descr…