Development and Preliminary Clinical Evaluation of a Multifunctional Operative Support Arm in Reproductive Laparoscopic Surgery: A Randomized Controlled Study.
To evaluate short-term clinical outcomes, surgeon-reported fatigue, and staff user experience associated with a multifunctional operative support arm in reproductive laparoscopic surgery. Single-center, parallel-group randomized controlled trial. Tertiary university-affiliated reproductive medicine…
Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Embolization of spontaneous retroperitoneal bleeding fed by aneurysmal arc of Bühler: Case report and technical considerations.
The arc of Bühler (AOB) is a rare embryonic anastomosis between the celiac artery and the superior mesenteric artery, which may become a crucial collateral pathway in cases of celiac axis stenosis. We report a challenging case of a 70-year-old woman presenting with hemorrhagic shock owing to a…
Thyroid function tests and resting heart rate in Graves` disease: a prospective longitudinal study.
Increased resting heart rate (RHR) is a typical sign of thyrotoxicosis. RHR may therefore serve as a monitoring tool, but longitudinal data on continuous measures of RHR and thyroid hormones are sparse. We evaluated the association between continuously monitored RHR and thyroid function tests in Gra…
Translating B-Cell and Plasma-Cell Targeting from Oncology to Autoimmunity: Modalities, Quantitative Bridging, and a Development Roadmap.
B cells drive B-cell malignancies and diverse autoimmune diseases through autoantibody production, antigen presentation, and cytokine dysregulation, and persistence of pathogenic B-cell or plasma-cell compartments. Across autoimmune diseases, the dominant pathogenic compartment varies, ranging from…
Objective assessment of physical activity using wearable devices in patients with mild-to-moderate Crohn's disease.
Inflammatory bowel disease (IBD) is influenced by genetic and environmental factors, including diet and physical activity (PA). IBD patients who engage in more PA report improvements in quality of life, symptom management, and fatigue levels. This report aims to characterize habitual PA collected us…
Interlayer Decoupling Growth for Atomically Thin Hybrid Perovskite Ferroelectrics with Giant Rashba Splitting Energy.
Ferroelectric materials enable direct spin-to-charge conversion through the electrical switching of ferroelectric polarization, which is crucial for future spintronic devices. Particularly, hybrid perovskite ferroelectrics with atomically thin thickness introduce additional degrees of freedom, there…