Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Development and Preliminary Clinical Evaluation of a Multifunctional Operative Support Arm in Reproductive Laparoscopic Surgery: A Randomized Controlled Study.
To evaluate short-term clinical outcomes, surgeon-reported fatigue, and staff user experience associated with a multifunctional operative support arm in reproductive laparoscopic surgery. Single-center, parallel-group randomized controlled trial. Tertiary university-affiliated reproductive medicine…
Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.
Medical devices have revolutionized patient care; however, their abiotic surfaces remain highly susceptible to bacterial biofilm formation, enabling immune evasion and antibiotic resistance. Although antibacterial coatings can mitigate bacterial colonization, many rely on antimicrobial agents that m…
Maternal and fetal outcomes of spinal cord stimulation in pregnancy: systematic review with descriptive meta-analysis.
Spinal cord stimulation (SCS) is an established therapy for refractory neuropathic pain and is increasingly used in women of reproductive age. However, evidence regarding the safety of SCS during pregnancy remains limited, and consolidated outcome data are lacking. Our objective was to systematicall…
A hypothesis on the aetiology of adenomyosis: is there an association between cumulative number of menstruations and severity of adenomyosis on ultrasound?
Adenomyosis is a common uterine disorder, yet its aetiology remains debated. The tissue injury and repair (TIAR) hypothesis suggests that repeated microtrauma from menstrual contractions damages the endometrial-myometrial interface, thereby contributing to development and progression of adenomyosis.…
Challenges and management of iliac-to-femoral artery injuries in endovascular aneurysm repair.
Iatrogenic injuries to iliac-to-femoral arteries during complex endovascular procedures remain serious and potentially life-threatening. These events are influenced by adverse anatomy, procedural difficulties, and prolonged device manipulation. This report assesses the occurrence and risk factors as…
Embolization of spontaneous retroperitoneal bleeding fed by aneurysmal arc of Bühler: Case report and technical considerations.
The arc of Bühler (AOB) is a rare embryonic anastomosis between the celiac artery and the superior mesenteric artery, which may become a crucial collateral pathway in cases of celiac axis stenosis. We report a challenging case of a 70-year-old woman presenting with hemorrhagic shock owing to a…