Systematic identification of bacterial neuraminidase inhibitors from Psoralea corylifolia using ultrafiltration-UPLC-Q-Orbitrap-MS and molecular dynamics.
Bacterial neuraminidase (BNA) is a potential target for discovering anti-infective agents. Here, the BNA inhibitory activity of the ethanolic extract of Psoralea corylifolia (EEPC) was investigated using integrated experimental and computational approaches. Affinity ultrafiltration-UPLC-Q-Orbitrap-M…
Low-density granulocyte-driven NET formation is associated with poor prognosis in IgA nephropathy with thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) is a common pathological phenotype of immunoglobulin A nephropathy (IgAN). Low-density granulocytes (LDGs) exhibit potent pro-inflammatory properties and promote neutrophil extracellular trap (NET) formation, playing a pivotal role in thrombus development. This study…
Factors predicting health-enhancing physical activity in patients with chronic widespread pain following a person-centred health plan.
Regular physical activity improves symptoms and overall health in people with chronic widespread pain. However, many struggle to stay active over time, highlighting the need for strategies that support long-term physical activity. To investigate if person-centred health plans that include physical a…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Effects of caffeine gum on same-day and subsequent neuromuscular performance under a standardized resistance-priming condition in male basketball players.
This study examined whether 3 mg·kg-1 (CAF3) and 6 mg·kg-1 (CAF6) caffeine gum, administered before a standardized resistance-priming (RP) protocol, produced additional neuromuscular performance advantages over placebo (PLA) at 1 h, 24 h, and 48 h in male basketball pl…
Pharmacological targeting of the TLR8/AP-1 axis ameliorates scleroderma skin inflammation and fibrosis by suppressing monocyte-mediated endothelial injury.
Toll-like receptor 8 (TLR8) is implicated in systemic sclerosis (SSc) pathogenesis, but its precise cellular mechanisms remain elusive. This study elucidates TLR8's role in monocyte-endothelial crosstalk and evaluates the therapeutic potential of targeting the TLR8/AP-1 axis in SSc. TLR expression i…
Chishizhi Yuyuliang Decoction Ameliorates Ulcerative Colitis in Mice by Promoting Colonic Epithelial Mucosal Healing via the CAV1/FA Axis.
This study aimed to investigate the therapeutic mechanisms of CY in treating UC using an integrated metabolomics and proteomics approach. A murine UC model was induced using dextran sulfate sodium (DSS). The therapeutic efficacy of CY was evaluated via histological examination (H&E staining) of colo…
Prevalence and incidence of fibromyalgia and associated severity in the United States using MarketScan.
Fibromyalgia is characterized by a range of symptoms, the most prominent being chronic widespread pain, fatigue, and unrefreshing sleep. This study estimated the diagnosed annual prevalence, incidence, and severity of fibromyalgia among adults (≥18 years) and the pediatric population (<18 yea…