Going high-throughput: Dynamic conformations and interactions in vivo.
Proteins are intrinsically dynamic molecules that continuously explore conformational ensembles to execute biological functions. Conventional structural biology methods rely on in vitro reconstitution of purified components and therefore capture predominantly static snapshots, often overlooking the…
Mass Spectrometry-Based Proteomics of Intestinal Organoids.
Proteomics, the large-scale study of proteins, enables the identification, quantification, and functional characterization of proteins, revealing post-translational modifications and protein interactions that are not apparent from transcriptomic data. Human organoids, which recapitulate the structur…
Calcium Isotopic Composition in Reindeer (Rangifer tarandus) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations?
Populations of North American caribou and Eurasian reindeer (Rangifer tarandus sspp.), essential for Arctic ecosystems and human communities, are experiencing unprecedented declines due to climate change and anthropogenic pressures. While understanding their historical resilience and demographic dyn…
Volatile organic compound profiles in oat are shaped by arbuscular mycorrhizal fungi, barley yellow dwarf virus and soil herbicide residues.
Volatile organic compounds (VOCs) are emitted by plants and vary in quantity and composition depending on biotic and abiotic environmental conditions. Plant-emitted VOCs are altered by attacking herbivores and pathogens, and have been increasingly found to be fine-tuned by microbial associates and e…
Subclinical cardiovascular risk among adolescents with HIV in Tanzania: the role of sleep behaviour and antiretroviral regimen on arterial stiffness.
Data on arterial stiffness among adolescents with HIV remain limited, particularly in sub-Saharan Africa, where the HIV burden is high. We aimed to assess arterial stiffness among adolescents with HIV, compare these measures with already published measures, and investigate factors associated with ar…
Human platelet 5-hydroxyindoleacetic acid concentrations are meager and unlikely to be physiologically active or play a role in inflammation.
A crucial role for platelet 5-hydroxyindoleacetic acid (5-HIAA, the principal serotonin metabolite) in human immune response and inflammation has been claimed. We have attempted to assess the likelihood of such a role for platelet 5-HAA. To assess the concentration of 5-HIAA in human platelets, we h…
Herbivore-induced sorghum volatiles mediate attraction of Cotesia flavipes: roles of DMNT and (Z)-3-hexenyl acetate in tritrophic chemical communication.
Herbivore-induced plant volatiles (HIPVs) influence chemical communication among plants, herbivores, and natural enemies and contribute to indirect plant defense. Previous work by our group characterized volatile emissions from sorghum following simulated herbivory and identified DMNT and (Z)-3-hexe…
Infection Risk During Rituximab Therapy in Multiple Sclerosis: Effect of Dosing Interval and Age.
Rituximab is the most frequently used disease-modifying therapy in multiple sclerosis (MS) in Norway. Extended dosing intervals beyond 6 months may offer the same efficacy, but the impact on infection risk is unclear. We examined how dosing frequency and age affect infection risk in rituximab-treate…