Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Environmental shaping of tolerance failure in autoimmune liver diseases: a phenotype-specific framework with primary biliary cholangitis as the strongest model.
Autoimmune liver diseases (primary biliary cholangitis, PBC; primary sclerosing cholangitis, PSC; autoimmune hepatitis, AIH) are three distinct, organ-specific autoimmune disorders that share loss of tolerance as the central pathophysiological mechanism but differ in target tissue, age of onset, gen…
Short, not skinny: The distinct sarcopenia phenotype of pediatric primary sclerosing cholangitis-inflammatory bowel disease.
Sarcopenia is prevalent in pediatric liver disease and inflammatory bowel disease (IBD) and predicts adverse outcomes. We aimed to compare sarcopenia prevalence in pediatric primary sclerosing cholangitis (PSC)-colitis versus non-PSC colitis, characterize longitudinal anthropometric trajectories, an…
Intermediate risk factors in ionising radiation cataractogenesis.
Recent reports indicate a new concept of low-dose ionising radiation cataractogenesis. In 2020, a two-stage aetiology of initiation and maturation was proposed by Richardson and colleagues for posterior subcapsular cataract (PSC) and perhaps cortical cataract development. The mechanisms involve vari…
Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.
Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-IBD affecting the colon (PSC-ulcerative colitis or PSC-UC) resembles clinical UC, but is characterised by less severe disease flares, right-colo…
Glucocorticoid Signaling in PSC-Derived Neural Systems to Elucidate Mechanisms of Stress-Induced Psychiatric Vulnerability.
Glucocorticoids are major regulators of human neural development and stress adaptation, yet their transcriptional effects across experimental paradigms remain poorly integrated. This review synthesizes evidence from 13 studies employing human induced pluripotent stem cell (hiPSC)-derived neural mode…
Agreement of Diaphragmatic Excursion Between Anterior Subcostal and Posterior Subcostal Ultrasonography in Premature Neonates.
Diaphragmatic ultrasound (DUS) is a non-invasive technique used to assess diaphragmatic function in neonates. However, the assessment of the diaphragm in the prone position is limited, as DUS traditionally uses the supine position. The agreement between the anterior subcostal approach (ASC), in the…
Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firing.
Chronic pain affects approximately one fifth of people worldwide and displays a huge burden for health care institutions. Some chronic pain conditions have a higher prevalence in women than men. Previous studies related these sex-specific differences to sex-hormone receptor activation and interactio…