Primary Sclerosing Cholangitis Recurrence After Liver Transplantation: A Systematic Review and Updated Meta-Analysis.
Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease. Liver transplantation (LT) remains the only definitive treatment for patients with advanced disease. However, recurrence of PSC (rPSC) after LT is still a significant clinical challenge. The aim of this study was t…
Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) guidelines on the use of autoantibody tests in the diagnosis of autoimmune liver diseases.
Autoimmune liver diseases (AILDs) are considered rare conditions, though the frequency of their diagnosis is increasing thanks to the introduction of new diagnostic tests and improvements in analytical technologies. In clinical practice, in patients with liver disease of unknown etiology, after a di…
Psychometric properties of the second version of the hospital survey on patient safety culture across a regional hospital system of Brazil.
The World Health Organization emphasizes regular patient safety culture (PSC) measurement for safer healthcare. While global interest grows, PSC awareness and measurement lags in Latin America. This study tackles the need for a validated PSC tool in Brazil. It aims to evaluate the psychometric prope…
Hypermucinous Dysplasia in Inflammatory Bowel Disease (IBD): Morphology, Molecular Features, and Its Place in the IBD-Associated Neoplastic Spectrum.
Long-standing inflammatory bowel disease (IBD) increases the risk of dysplasia and colorectal cancer (CRC), particularly in patients with extensive disease or coexisting primary sclerosing cholangitis (PSC). Several non-conventional dysplasia subtypes have been identified. Hypermucinous dysplasia wa…
Ti3C2Tx (MXene)-Polystyrene Based Passivation for Perovskite Solar Cells With Enhanced Stability.
Perovskite solar cells are the fastest advancing photovoltaic technology, but their long-term durability remains a major barrier to commercialization. Surface passivation is a promising and straightforward approach to improve the stability of PSCs while enhancing their performance through surface de…
The Interleukin-17-T helper 17 axis in primary sclerosing cholangitis: A narrative review of an emerging pathogenic frontier.
Interleukin-17 (IL-17) and IL-17+ secretory cells, including T helper 17 (Th17) cells play pivotal roles in autoimmune diseases such as psoriasis. Emerging evidence implicates the IL-17 pathway in primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease lacking approved pharmacologi…
Lactobacillus murinus improves liver fibrosis in primary sclerosing cholangitis mice by decreasing taurocholic acid and regulating M2 macrophage polarization.
Hepatic accumulation of bile acids (BAs) contributes to cholestasis-induced liver injury and fibrosis. Our previous studies have shown that Lactobacillus murinus ( L. murinus) alleviates liver fibrosis in primary sclerosing cholangitis (PSC) by modulating bile acid metabolism. In this study, we foun…
Machine learning prediction of dual absorber lead-free perovskite solar cells for boosting PCE.
Curtailing the toxicity level of perovskites is a considerable obstacle resisting the wide-scale commercialization of perovskite solar cells (PSCs). This study investigates the impact of implementing several charge transport layers (CTLs) on the performance of the proposed lead-free Cs2TiCl6/ Cs2AgB…