Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Lactobacillus johnsonii mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα-SCD1 axis.
Ulcerative colitis (UC) is a systemic disease that can involve multiple organs, and hepatobiliary diseases in UC patients are frequently observed. However, the pathogenesis of UC and its associated hepatobiliary complications remains elusive, and limited therapeutic options are available. This study…
Baicalein solid dispersion prepared by solvent evaporation enhances oral bioavailability and alleviates ulcerative colitis.
Baicalein (BAC) is a flavonoid compound known for its effectiveness in treating ulcerative colitis (UC). However, its clinical application is limited by poor water solubility, low stability, and low oral bioavailability. In this study, a baicalein solid dispersion (BAC-SD) was prepared using Polyvin…
Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.
Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of the intestinal metabolome associated with dysbiosis can trigger chronic inflammation. However, it remains…
Triptolide loaded cerium oxide nanozyme based oral nanoplatform for targeted colitis therapy.
Ulcerative colitis (UC) is a type of colonic inflammation characterized by immune dysregulation and intestinal inflammation. Cerium oxide (CeO₂) nanozyme can effectively downregulate reactive oxygen species (ROS), but it lacks anti-inflammatory and other pharmacological activities. Triptolide…
Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.
Flagellin, the structural protein of bacterial flagella, activates the innate immune receptor Toll-like receptor 5 (TLR5). However, the ability of different flagellins to bind and stimulate TLR5 varies widely, suggesting that the composition of an individual's flagellin repertoire, defined as flagel…
TIME-trend and forecasting of the economic impact of inflammatory bowel disease in Catalonia: a population-based analysis.
Few studies have assessed the distribution and temporal trends of healthcare expenditures related to inflammatory bowel disease (IBD). The aims of the study were to analyze the expenditure trends for IBD patients in Catalonia from 2011 to 2024, to identify key cost drivers, and to forecast future co…
A physiology-informed microRNA framework for urothelial carcinoma in hemodialysis patients.
Urothelial carcinoma (UC) is a major cancer globally and disproportionately frequent among hemodialysis (HD) patients. Currently, there are no reliable blood-based clinical markers to detect or monitor this cancer in HD population. In this research, we investigate the functional roles of these miRNA…