Innovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs.
The potential of senescent cell clearance to extend healthspan and delay the onset of age-related diseases has driven the development of innovative senotherapeutics. Thus, niosome-based gene therapy has emerged as a promising strategy to overcome the off-target limitations of first-generation senoly…
Creation of a quality assurance and Regulatory Specialist role: A pilot study.
Quality assurance activities and research compliance activities are paramount to a healthy and successful research program to ensure participant safety and data integrity are upheld. The UC Davis Infectious Diseases Research Unit (IDRU) supports both interventional and observational research, and ab…
Effects of protein, muscle rehabilitation and trunk neuromuscular electrostimulation in patients with prolonged mechanical ventilation: a prospective, randomized controlled pilot study.
Attenuating diaphragmatic dysfunction is important in patients with prolonged mechanical ventilation (PMV). The clinical impact of protein supplementation, core muscle rehabilitation and neuromuscular electrostimulation (NMES) in patients with PMV remains unknown. We conducted a single center, prosp…
Dna aneuploidy and urothelial carcinoma: A meta-analysis.
Urothelial carcinoma (UC) is regarded as the third most common cancer in adults, with a high incidence and mortality rate, and lacks specific tumor markers. With the advancement of technology, DNA ploidy analysis technology has become more convenient and efficient. Through meta-analysis of the corre…
Brief report: Effectiveness and safety of recombinant zoster vaccine in inflammatory bowel disease patients aged 18 years and older: A matched cohort and self-controlled case series study.
Individuals with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ). Using a matched cohort design, we evaluated the vaccine effectiveness (VE) of recombinant zoster vaccine (RZV) against HZ among IBD patients aged ≥18 years. Within the Kaiser Permanente South…
Water-triggered in-situ gelling phospholipid oil enema for enhanced budesonide delivery and mucosal healing in ulcerative colitis.
Budesonide (BUD) enema therapy for ulcerative colitis (UC) is limited by poor solubility, inadequate bio-adhesion, and rapid clearance due to intestinal peristalsis. To address the limitations of conventional budesonide enemas, we designed a water-triggered in situ phase-transition phospholipid form…
Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that primarily affects the colon. Among its extraintestinal complications, cerebral venous sinus thrombosis (CVST) is a rare yet potentially life-threatening emergency that can manifest as headaches, seizures, and/or neurological…