Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
Chishizhi Yuyuliang Decoction Ameliorates Ulcerative Colitis in Mice by Promoting Colonic Epithelial Mucosal Healing via the CAV1/FA Axis.
This study aimed to investigate the therapeutic mechanisms of CY in treating UC using an integrated metabolomics and proteomics approach. A murine UC model was induced using dextran sulfate sodium (DSS). The therapeutic efficacy of CY was evaluated via histological examination (H&E staining) of colo…
The complement system in inflammatory bowel disease: from early observations to emerging frontiers.
The complement system is one of the most evolutionarily conserved arms of innate immunity and has re-emerged as an important regulator of intestinal inflammation in inflammatory bowel disease (IBD). Early observations from the mid-1970 s such as complement deposition in diseased bowel tissue…
Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis.
High‑throughput transcriptomic technologies offer a systems‑level approach to unravel the mechanisms of complex immune disorders. Inflammatory Bowel Disease (IBD), a classic example of such disorders, involves intricate interactions between genetics, microbiota and immune dysfunction.…
Prognostic significance of squamous differentiation in pT2N0 urothelial bladder cancer.
Bladder cancer is the ninth most common malignancy worldwide, with urothelial carcinoma (UC) representing the predominant histopathological subtype. UC may present as pure urothelial carcinoma (PUC), or alongside other variant histologies (VHs), with squamous differentiation in UC (SD) being the mos…
Incorporating Hypofractionated Radiotherapy Improves Management of Canine Urothelial Carcinoma: A Retrospective Study.
This retrospective study evaluated a novel hypofractionated radiation therapy (RT) protocol for canine urothelial carcinoma (UC). Medical records of dogs diagnosed with UC and treated were retrospectively reviewed. Inclusion criteria included diagnosis of UC, treatment with hypofractionated RT, abse…
Benefits and mechanisms of polysaccharides derived from traditional Chinese medicine for ulcerative colitis treatment (Review).
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea and bloody mucopurulent stools. The UC global incidence is rising and conventional therapies remain limited. Therefore, there is an urgent need for novel treatments. Polysaccharides derived from…
FMultifunctional magnetic resonance imaging for the assessment of renal pathological alterations in IgA nephropathy.
We aimed to evaluate the application value of multiparametric diffusion weighted magnetic resonance imaging (MRI) for the assessment and risk stratification of renal histopathological injuries in patients with IgA nephropathy (IgAN), as an exploratory study. 95 patients were prospectively enrolled,…