Effects of caffeine gum on same-day and subsequent neuromuscular performance under a standardized resistance-priming condition in male basketball players.
This study examined whether 3 mg·kg-1 (CAF3) and 6 mg·kg-1 (CAF6) caffeine gum, administered before a standardized resistance-priming (RP) protocol, produced additional neuromuscular performance advantages over placebo (PLA) at 1 h, 24 h, and 48 h in male basketball pl…
Relation of nailfold capillaries and autoantibodies to mortality in patients with Raynaud's phenomenon: a retrospective analysis.
The presence of abnormal nailfold capillaries and antinuclear antibodies (ANA) is associated with increased all-cause mortality in patients presenting with incipient Raynaud's phenomenon (RP). We conducted a retrospective analysis aiming to assess the association between abnormal nailfold capillarie…
Vitamin B3 (Nicotinamide) Supplementation in Primary and Scleroderma-Related Raynaud Phenomenon.
The aim of this study was to explore if vitamin B3 (nicotinamide) supplementation is a safe and effective adjunctive therapy for patients with primary Raynaud phenomenon (RP) and scleroderma-related RP. The effect of nicotinamide supplementation in human patients with RP has not been studied before.…
A natural pectic polysaccharide from rhubarb reprograms dysbiotic gut microbiota and resolves mucosal inflammation in ulcerative colitis.
Ulcerative colitis (UC) remains a major therapeutic challenge. Although natural polysaccharides exhibit therapeutic potential, their structure-activity relationships are still unclear, which limits their clinical application. This study aimed to investigate the protective effect of a rhubarb-derived…
A systematic review of abatacept and belatacept in immune-mediated diseases.
Abatacept (ABA) and belatacept (BEL) are immunomodulatory fusion proteins in which the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is linked to the Fc fragment of human IgG1. Functionally, they bind to cell surface antigens CD80 and CD86 on antigen-presenting cells,…
Stepwise Diagnostic Evaluation of Chinese Large Language Models: Comparative Study of Common and Rare Diseases.
Large language models (LLMs) are increasingly applied in clinical decision support, yet their diagnostic performance in Chinese-language settings and under realistic clinical workflows remains unclear. In particular, how LLMs perform across diseases with different prevalence and under stepwise diagn…
Raynaud's phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy.
Raynaud's phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed co…
Clinical characteristics and concordance of anti-MDA5 autoantibodies: A multicentre Australian study.
In Australia, anti-MDA5 antibodies are exclusively tested by line immunoblot assay (LIA). The clinical concordance of a LIA-positive anti-MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti-MDA5 antibodies. Electronic record…