Effects of caffeine gum on same-day and subsequent neuromuscular performance under a standardized resistance-priming condition in male basketball players.
This study examined whether 3 mg·kg-1 (CAF3) and 6 mg·kg-1 (CAF6) caffeine gum, administered before a standardized resistance-priming (RP) protocol, produced additional neuromuscular performance advantages over placebo (PLA) at 1 h, 24 h, and 48 h in male basketball pl…
Genetic contributions to systemic autoimmunity are often considered more significant in children than in adults. As such, genetic evaluation may be more frequently pursued in pediatric rheumatology patients. Motivated by the discovery of a STING-associated vasculopathy with onset in infancy (SAVI) m…
Deep immunological resetting in refractory systemic lupus erythematosus post-kidney transplantation: A longitudinal immunophenotypic analysis.
BackgroundA 66-year-old female with a 15-year history of refractory lupus nephritis, complicated by severe hypersplenism requiring splenectomy and 8 years of hemodialysis, successfully underwent deceased-donor kidney transplantation. Post-transplantation, she achieved an unprecedented, durable…
Assessment of the Vestibulo-Ocular reflex in polycystic Ovary Syndrome: a Case-Control study using video head impulse testing.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect multiple organ systems. While cochlear and otolith involvement has been investigated, the impact on semicircular canal-mediated vestibulo-ocular reflex (VOR) function remains unclear. To evaluate canal-specific, high-fre…
An observational cohort study evaluating adalimumab concentrations for predicting non-recapture of biochemical response after dose escalation in patients with Crohn's disease experiencing secondary loss of response.
There is limited evidence to support optimal concentrations for therapeutic drug monitoring in patients with Crohn's disease (CD) who experience a loss of response (LOR) to tumour necrosis factor antagonists. This study aimed to determine the threshold trough adalimumab concentration beyond which pa…
Real-world effectiveness and safety of apremilast in psoriatic arthritis: results from the multicenter Italian MAPSI II study.
To assess the effectiveness and safety of apremilast in the treatment of psoriatic arthritis (PsA) in a real-world setting across multiple rheumatology centers in Italy. MAPSI II is a multicenter, observational real-world study including adult patients with active PsA treated with apremilast. Patien…
High-altitude headache: Insights into pathophysiology and potential treatment implications.
High-altitude headache (HAH) is the most common neurological manifestation triggered by hypoxia during rapid ascent above 2500 m, often presenting as an isolated symptom or as part of acute mountain sickness (AMS). HAH shares clinical features with migraine, cluster headache and other primary h…
Involvement of the External Ear by inflammatory Skin Diseases.
Chronic inflammatory skin disorders cover both frequent and rare dermatoses. The etiopathology of these diseases is broad and ranges from genetic factors to environmental and life-style issues. In this review, we focus on affections of the auricle by the eczema group, psoriasis, and pityriasis rubra…