Effects of caffeine gum on same-day and subsequent neuromuscular performance under a standardized resistance-priming condition in male basketball players.
This study examined whether 3 mg·kg-1 (CAF3) and 6 mg·kg-1 (CAF6) caffeine gum, administered before a standardized resistance-priming (RP) protocol, produced additional neuromuscular performance advantages over placebo (PLA) at 1 h, 24 h, and 48 h in male basketball pl…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
Circulating Antinephrin Antibodies in Adult Chinese Patients With IgAN and Nephrotic-Range Proteinuria.
Antinephrin autoantibodies are detectable in podocytopathies such as minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS); however, their prevalence and clinical relevance in IgA nephropathy (IgAN) with nephrotic-range proteinuria (NRP) and nephrotic syndrome (NS) are u…
Early and clinically meaningful functional improvement following CGRP monoclonal antibodies in adolescents with migraine: A real-world retrospective study.
BackgroundEvidence supporting calcitonin gene-related peptide monoclonal antibody (CGRP mAb) use in adolescents with migraine is limited. Rapid recovery for daily school functioning is particularly important during this stage of life. We aimed to evaluate early functional outcomes in daily and schoo…
Clinical presentation of chronic abacterial prostatitis shows no association with TAS2R38 taster status.
Chronic prostatitis/chronic pelvic pain syndrome CP/CPPS is a relatively common disease and shows an association with urogenital infections. Tuft cells in general have been identified at various entry points into the body (respiratory tract, gastrointestinal tract, and urogenital tract) and are seen…
Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).
BackgroundRimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist approved for both acute and preventive treatment of episodic migraine. Real-world data on its preventive use remain limited, particularly in patients with multiple prior preventive failures. This study evaluated the…
Serum REG3α as a biomarker for clinical and endoscopic activity in ulcerative colitis.
Current biomarkers, including serum C-reactive protein (CRP) and fecal calprotectin, have limitations in monitoring disease activity of ulcerative colitis (UC). Regenerating islet-derived protein 3α (REG3α), which is constitutively produced by Paneth cells, is a bactericidal C-type prote…
Validation of EEG mental workload markers using integrated statistical and machine learning analyses.
Attentional and working-memory processes can be monitored noninvasively using electroencephalography (EEG), which provides physiological indices of mental workload. Prior studies consistently report increased frontal-midline theta and beta power together with suppression of posterior alpha activity…