Occupational category, job type, and sarcoidosis: Findings from a French multicenter study.
Evidence supporting an occupational hypothesis for sarcoidosis remains limited. The hypothesis of the present study was that some occupational exposures might be more prevalent among sarcoidosis patients than in the French population. A cross-sectional observational study design was used to collect…
Monitoring the safety of the adjuvanted human papillomavirus vaccine HPV-16/18-AS04 in association with pregnancy and potential immune-related diseases in China: A retrospective observational cohort study.
Human papillomavirus (HPV) infection causes cervical cancer. The objective of the study is to monitor AS04-adjuvanted HPV-16/18 vaccine (Cervarix, GSK) safety in a real-world setting in China, using electronic health records from the Yinzhou Regional Health Information Platform (YRHIP). This retrosp…
Sarcoidosis is a systemic granulomatous disorder of unclear origin, most commonly impacting the lungs and mediastinal lymph nodes. Respiratory manifestations occur in most patients and are the main contributors to disease-related morbidity and mortality. Despite decades of clinical experience, the e…
Nonsteroid treatment options in (pulmonary) sarcoidosis. When to consider and why?
Sarcoidosis requires treatment in 30-50% of cases. According to current guidelines, corticosteroids (CS) are the initial drugs of choice, particularly for patients with major organ involvement or when rapid symptom relief is required. However, CS use is associated with substantial toxicity even at l…
Risk factors for adverse events or use of high-potency corticosteroids in non-infectious uveitis: a Japan claims database study (J-CAT2).
The J-CAT2 study (#jRCT1030240195) aimed to evaluate treatment and patient factors associated with risk of complications/adverse events (AEs) or high corticosteroid exposure in patients with non-infectious uveitis (NIU) using advanced quantitative and visual analytical approaches. The study included…
Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?
Cardiac sarcoidosis (CS) is associated with significant morbidity and mortality, yet its diagnosis remains challenging due to heterogeneous clinical presentations and patchy myocardial involvement. Although endomyocardial biopsy has historically been regarded as the diagnostic gold standard, its lim…
A Six Year Old Boy with Lepromatous Leprosy: A Case Report Revealing an Unsolved Mystery.
Leprosy is a chronic granulomatous disease resulting from infection with the unculturable pathogen Mycobacterium leprae. Lepromatous leprosy is the most severe form, typically seen in adults with poor immune response to the bacillus. It is exceptionally rare in young children, specially under 10 yea…
Carotid Artery Dissection as Initial Manifestation of Overlapping Sarcoidosis and Antiphospholipid Syndrome in a Young Woman.
In young-onset stroke with inflammatory features, consider systemic causes alongside vascular imaging. This case links cervical internal carotid artery dissection with coexisting sarcoidosis and antiphospholipid syndrome, highlighting the value of targeted work-up and appropriate long-term anticoagu…