Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
Occupational category, job type, and sarcoidosis: Findings from a French multicenter study.
Evidence supporting an occupational hypothesis for sarcoidosis remains limited. The hypothesis of the present study was that some occupational exposures might be more prevalent among sarcoidosis patients than in the French population. A cross-sectional observational study design was used to collect…
Monitoring the safety of the adjuvanted human papillomavirus vaccine HPV-16/18-AS04 in association with pregnancy and potential immune-related diseases in China: A retrospective observational cohort study.
Human papillomavirus (HPV) infection causes cervical cancer. The objective of the study is to monitor AS04-adjuvanted HPV-16/18 vaccine (Cervarix, GSK) safety in a real-world setting in China, using electronic health records from the Yinzhou Regional Health Information Platform (YRHIP). This retrosp…
Sustained monomorphic ventricular tachycardia as the first manifestation of probable cardiac sarcoidosis: A case report.
Cardiac sarcoidosis is an inflammatory heart disease that can cause conduction block, ventricular arrhythmias, and cardiomyopathy. Sustained monomorphic ventricular tachycardia is a high-risk presentation and may be the first sign of disease. A 69-year-old man with paroxysmal atrial fibrillation and…
Tumefactive parenchymal lesion of neurosarcoidosis responsive to infliximab.
Neurosarcoidosis is an uncommon manifestation of systemic sarcoidosis and can involve any part of the nervous system. Intraparenchymal tumefactive lesions are particularly rare and pose a diagnostic challenge due to their radiographic resemblance to high-grade gliomas or metastatic disease. Optimal…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
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Cirrhosis Risk in Sarcoidosis Without Documented Hepatic Involvement-A Large Nationwide Population-Based Cohort Study.
Given the likely underestimation of hepatic sarcoidosis, the aims were to evaluate long-term cirrhosis risk in patients with sarcoidosis without documented hepatic involvement at baseline and to assess the impact of multi-organ disease and immunomodulatory therapies on cirrhosis risk. A retrospectiv…