CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomization (MR) using expression quantitative trait loci (eQTL) and…
Hashimoto's thyroiditis influences tumor cell states and intratumoral microbiota in papillary thyroid carcinoma.
Hashimoto's thyroiditis is associated with reduced lymph node metastasis in papillary thyroid carcinoma, suggesting that the autoimmune microenvironment may influence tumor progression. We utilized single-cell RNA sequencing and intratumoral 16S ribosomal RNA gene sequencing to investigate malignant…
Rate of Autoimmune Diseases in the 10 Years Preceding Myasthenia Gravis Diagnosis: A Nationwide Cohort Study in South Korea.
Patients with myasthenia gravis (MG) are frequently associated with other autoimmune diseases. However, the temporal relationship between autoimmune diseases and MG remains unclear. This study aimed to evaluate the rates and temporal patterns of autoimmune diseases during the 10 years preceding MG d…
Incidence, Patterns and Predictors of Alemtuzumab-Induced Thyroid Dysfunction in Patients With Multiple Sclerosis: A Northern Ireland Cohort Study.
Alemtuzumab (Lemtrada) is highly effective for selected relapsing multiple sclerosis (MS) but can cause autoimmune thyroid dysfunction (AITD). Our aim was to retrospectively review patients and the monitoring of their thyroid function tests (TFTs) during and after treatment with alemtuzumab. We want…
Under-recognition of autoimmune polyendocrine syndromes in T1DM: results from an extended screening workup.
Type 1 diabetes mellitus (T1DM) is frequently associated with other autoimmune disorders, particularly autoimmune thyroid disease (AITD) and celiac disease. Guidelines recommend screening for thyroid and celiac disease in T1DM patients. Nevertheless, in case of their positivity, indicating the prese…
Variable intensity interval training improves cardiorespiratory fitness and quality of life across Hashimoto's stages and lowers TSH in subclinical patients: a 12-week supervised study.
This study aimed to evaluate the effects of variable intensity interval training (VIIT) on thyroid function, body composition, cardiorespiratory fitness, and quality of life (QoL) in women with Hashimoto's thyroiditis (HT) at different stages of disease progression. Thirty-one women (aged 18-65) wit…
Vitamin D deficiency is common in Hashimoto's thyroiditis, while VDR FokI shows subtype-specific association with gravis disease in Jordan: a case-control study.
Vitamin D (VD) plays a crucial role in immune regulation via vitamin D receptor (VDR). VD deficiency and VDR gene polymorphism have been linked to autoimmune thyroid disease (AITD). This study investigated serum VD levels and four key VDR gene polymorphism (ApI, BsmI, FokI, TaqI) in the Jordanian po…
Is Hashimoto's Thyroiditis Associated with Insulin Resistance Markers?
Hashimoto's thyroiditis causes cell death, hypothyroidism, and insulin resistance. Cholecystokinin, orexin-A, and cocaine and amphetamine-regulated transcript are essential regulators of various endocrine and autonomic processes, including food intake. We aimed to determine the cocaine and amphetami…