CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomization (MR) using expression quantitative trait loci (eQTL) and…
Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.
Vitamin D, an important immunomodulator, has been implicated in the pathogenesis of thyroid disease. Although several studies have reported lower serum vitamin D levels in patients with autoimmune thyroid diseases (AITDS) and thyroid cancer, others have yielded shown inconsistent findings, leaving t…
Ratiometric electrochemical-colorimetric dual-mode biosensor based on Cu-MOF and AuPt@PBA nanomaterials for ultrasensitive and accurate detection of DR1.
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disorder that increasingly threats human health and quality of life. As down-regulator of transcription 1 (DR1) is a key biomarker for HT, developing efficient DR1 detection methods is crucial for monitoring disease progression. Here, a novel ra…
Evaluation of Thyroid Gland Vascularity in Hashimoto's Thyroiditis Using Ultra-Microangiography Vascular Imaging Technique.
In this study, we aimed to investigate possible differences in thyroid parenchymal vascularity between newly diagnosed and untreated patients with Hashimoto's thyroiditis (HT) and healthy participants by applying the subtraction ultra-microangiography (sUMA) vascular imaging technique. This study wa…
Hashimoto's thyroiditis is the most common cause of primary hypothyroidism in iodine-sufficient regions and is characterised by immune-mediated injury to thyroid follicular cells. Its pathophysiology involves an interplay of genetic susceptibility, environmental exposures, and epigenetic modificatio…
Healthcare professionals' experiences of providing care for patients with Graves' disease: a qualitative interview study in Swedish secondary care.
Graves' disease (GD) is an autoimmune thyroid disease, mainly affecting women of working age. The hyperthyroidism in GD is characterised by physical symptoms (tachycardia, weight loss, sweating and tremors) as well as cognitive and psychological problems that have a major impact on the daily lives o…
Levothyroxine adherence in primary hypothyroidism: clinical impact, measurement challenges, and opportunities for personalized care.
Primary hypothyroidism, most commonly caused by Hashimoto's thyroiditis, is a highly prevalent chronic condition typically managed with lifelong levothyroxine therapy. Although treatment is generally straightforward, a substantial proportion of patients do not achieve stable biochemical control or c…
Coordinated TNF-NF-κB and PI3K-Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study.
To predict the polypharmacological mechanism of Yueju pill (YJP) against Hashimoto's thyroiditis (HT), this study integrated network pharmacology and molecular docking to develop a computationally derived "dual-axis core" hypothesis involving the TNF-NF-κB inflammatory axis and the PI3K-Akt su…