Advancing PCOS drug development: multi-omics discovery of key targets and repurposable compounds.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-age women, characterized by limited therapeutic options that address its underlying mechanisms. This study aimed to identify novel druggable protein targets for PCOS using a multi-omics integrative approach. Proteome-…
Relationship between anti-Müllerian hormone concentration in the peripheral blood of women and aneuploid pregnancy.
While diminished ovarian reserve (DOR) is a risk factor for aneuploid pregnancies, its role in women with a history of aneuploid pregnancy remains poorly understood. Anti-Müllerian hormone (AMH) is an effective biomarker for assessing ovarian reserve. This study evaluated ovarian reserve in wom…
Polycystic ovary syndrome and its association with reproductive cancers in women.
To determine whether individuals with PCOS are at an increased risk of female reproductive cancers. A retrospective cohort study was performed using Optum's de-identified Clinformatics® Data Mart Database (2000-2022). Females aged 18-50 with no prior reproductive cancer history. Individuals wit…
Changes in facial emotion processing and depression and anxiety symptoms with polycystic ovary syndrome treatment: a longitudinal, naturalistic study.
Changes in facial emotion processing were examined over the course of anti-androgen treatment in women with PCOS. We also explored whether these changes in emotion processing correlated with changes in mood and anxiety symptoms over treatment. Thirty-three women with PCOS received 12 weeks of natura…
PCOS and breast cancer risk: hormonal modulation and epidemiological trends.
Hormonal signals intricately regulate breast growth and development. Any perturbations due to altered endocrine and metabolic conditions, such as in polycystic ovary syndrome (PCOS), may influence breast cancer risk. This review highlights the susceptibility of women with PCOS to breast cancer, with…
The crosslink between autophagy and ferroptosis in polycystic ovary syndrome: from synergistic pathogenesis to targeted therapy.
Polycystic ovary syndrome (PCOS) is a highly heterogeneous endocrine-metabolic disorder whose core pathological features-follicular atresia and ovulatory dysfunction-are attributed to functional failure of ovarian granulosa cells (GCs). Although autophagy (a cellular quality-control mechanism) and f…
Clinical significance of microRNA-30d-5p and TGF-β/Smad2 pathway expression levels in polycystic ovary syndrome patients.
To investigate the clinical significance of miR-30d-5p and transforming growth factor-β (TGF-β)/Smad2 pathway expression levels in polycystic ovary syndrome (PCOS) patients. A total of 82 PCOS patients undergoing their first in vitro fertilization-embryo transfer (IVF-ET) (PCOS group) an…
Retrospective analysis of the association between anti-Müllerian hormone levels and metabolism and reproductive outcome across different PCOS phenotypes.
The aim of this study is to explore the relationship between the levels of anti-Müllerian hormone (AMH) and metabolic and reproductive outcomes across different polycystic ovary syndrome (PCOS) phenotypes. In this retrospective study, 286 PCOS patients undergoing intrauterine insemination (IUI)…