Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.
Studies have reported inconsistent findings regarding the potential effects of polycystic ovary syndrome (PCOS) on neurocognitive function. This study aimed to investigate whether cognitive function, particularly spatial learning and memory, and hippocampal tissue are impaired in middle-aged rats wi…
Integrated multi-omics analyses identify an RAS-SLC11A2-associated molecular framework linking iron metabolism with PCOS-related cardiometabolic risk.
PCOS is a common endocrine disorder with elevated cardiometabolic risk, yet the role of the renin-angiotensin system (RAS)-iron metabolism axis in this comorbidity remains unclear. We explored its underlying mechanisms and evaluated the therapeutic potential of gentiopicroside. Integrated multi-omic…
Autophagy activation in granulosa cells as a mechanism of astaxanthin action: evidence from a pilot randomised trial in PMOS-associated infertility.
Astaxanthin (AST) has been reported to influence oxidative stress, endoplasmic reticulum stress, and apoptosis in women with polyendocrine metabolic ovarian syndrome (PMOS), formerly referred to as polycystic ovary syndrome (PCOS), but its effects on granulosa-cell (GC) autophagy remain unclear. Giv…
Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation remains incompletely understood, particularly in South Indian populations. This study aimed to ev…
Diagnostic value of serum miR-101-3p combined with Doppler ultrasound in polycystic ovarian syndrome: a retrospective study.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder with limited diagnostic biomarkers. miR-101-3p is implicated in endocrine regulation and ovarian function, with emerging evidence suggesting its potential as a biomarker for reproductive disorders. This study aimed to explore the diag…
Hotspots and research trends of exercise in polycystic ovary syndrome: a bibliometric analysis from 2005 to 2025.
Polycystic Ovary Syndrome (PCOS) imposes substantial metabolic and reproductive burdens. Exercise has emerged as a crucial lifestyle intervention, and corresponding scientific interest has expanded. This study provides a comprehensive bibliometric analysis of global research on the intersecting PCOS…
A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based food supplement before IVF improves fertility in women with PCOS: a pilot observational retrospective cohort study.
PCOS is frequently associated with metabolic disturbances, including a high prevalence of insulin resistance and compensatory hyperinsulinemia, which can impair reproductive outcomes. Previous evidence indicates that combining myo-inositol and D-chiro-inositol in a specific 3.6:1 ratio may support o…