miR-148a-3p Is Elevated in Serum of PCOS Women and Modulates ALDH1A3-Retinoic Acid Signaling to Reduce Estrogen Synthesis in Granulosa-Like Cells.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with substantial reproductive and metabolic consequences, yet its molecular mechanisms remain incompletely understood. This study investigated circulating microRNAs (miRNAs) as potential regulators of ovarian steroidogenesis cont…
This prose poem explores a nonbinary and transmasculine experience with total hysterectomy salpingectomy/ooporectomy as a gender-affirming procedure as well as treatment for stage four endometriosis, polycystic ovarian syndrome, and multiple fibroids. In addition, it discusses ancestral lines, namel…
Where are we in the diagnosis and treatment of hirsutism? A narrative review.
Hirsutism is a prevalent androgen-dependent condition that significantly affects women's physical and psychological health. Despite decades of study, major gaps persist in understanding local androgen metabolism, the role of insulin resistance, and individualized treatment responses. This review aim…
The effect of high intensity interval training on free androgen index in patients with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is a multifactorial disorder characterized by hyperandrogenism, ovulatory dysfunction, and metabolic disturbances. Physical exercise is known to improve metabolic and hormonal profiles, yet the optimal type and intensity remain unclear. To compare the effects of high…
NOVEL POLYCYSTIC OVARY SYNDROME CLUSTERS IDENTIFIED BY ENDOCRINE-METABOLIC CLUSTERING: IMPACT ON REPRODUCTIVE OUTCOMES AFTER FERTILITY TREATMENT.
To identify novel polycystic ovary syndrome (PCOS) clusters utilizing endocrine and metabolic clustering and to investigate the impact of these clusters on reproductive and pregnancy outcomes following fertility treatment. Prospective study. IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam, between…
Safety and efficacy of laparoscopic sleeve gastrectomy in adolescents with Grade V obesity (BMI ≥ 50 kg/m2).
To investigate the effects of Laparoscopic Sleeve Gastrectomy (LSG) on the safety profile and metabolic parameter improvement in adolescents (10‒17 years-old) with grade IV obesity (BMI ≥ 50 kg/m2). From May 2023 to September 2024, a total of 60 adolescent patients with grade IV obesit…
Untargeted microLC-HRMS/MS for Measuring Endogenous Steroids in Mouse Plasma and Human Serum Samples Applied to Studying Polycystic Ovary Syndrome.
Steroids play essential roles in regulating metabolism, response to stress, electrolyte balance, and reproductive function; however, their analysis in complex biological matrices remains challenging. Low endogenous concentrations, structural similarities, and poor ionization efficiencies can limit t…