Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation remains incompletely understood, particularly in South Indian populations. This study aimed to ev…
A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based food supplement before IVF improves fertility in women with PCOS: a pilot observational retrospective cohort study.
PCOS is frequently associated with metabolic disturbances, including a high prevalence of insulin resistance and compensatory hyperinsulinemia, which can impair reproductive outcomes. Previous evidence indicates that combining myo-inositol and D-chiro-inositol in a specific 3.6:1 ratio may support o…
Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions.
The present study investigated the role of melatonin (MT) in regulating mitochondrial function via sirtuin 3 (SIRT3) in granulosa cells (GCs) from patients with polycystic ovary syndrome (PCOS), with a focus on mitochondrial protection. Notably, GCs isolated from patients with PCOS exhibited mitocho…
Therapeutic potential of natural products in polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder in women of reproductive age. Its multifactorial pathogenesis involves complex interactions among genetic patterns, environmental factors, insulin resistance (IR), chronic inflammation, and persistent oxidative s…
Construction and validation of a machine learning model for predicting early pregnancy in patients with polycystic ovary syndrome: a retrospective cohort study.
Polycystic ovary syndrome (PCOS) is a leading cause of female infertility, and early pregnancy outcomes in affected women are affected by multiple interactive factors; however, no well-established predictive tools are available. This study aimed to develop and validate machine learning (ML) models f…
Exosomal lncRNA-miRNA-mRNA regulatory axis may drive inflammation in polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in reproductive-aged women and is associated with reproductive dysfunction, metabolic abnormalities, and chronic low-grade inflammation. Emerging evidence highlights the role of circulating exosomal inflammatory cytoki…
Consensus statement of dienogest as a progestin in contraception and non-contraceptive clinical entities (heavy menstrual bleeding, acne and hirsutism). Narrative review of the literature and recent developments.
Combined oral contraceptives (COC)s, besides offering a reliable and safe contraception, offer a variety of non-contraceptive health benefits and therapeutic positive aspects. While contraceptive use is the primary indication for COC use, a variety of medical conditions have been added in the summar…