Neonatal vitamin D levels and autoimmune disorders: a Danish population-based cohort study.
To examine the associations of neonatal 25-hydroxyvitamin D (25(OH)D) and vitamin D-binding protein (DBP), and their corresponding genetic predictors, with the risk of nine autoimmune disorders. We conducted a population-based cohort study of a random sample of individuals born in Denmark between 19…
Hyperthyroidism Is Genetically Associated With Reduced Risk of Parkinson's Disease: A Mendelian Randomization Analysis.
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose aetiology involves an intricate interplay of genetic, immune, metabolic and environmental factors. Endocrine dysfunction-particularly disturbances of thyroid hormone signalling-has been proposed as a contributor to neurodegen…
I saw the "thyroid inferno" sign: A fiery Doppler signature of Graves' disease.
Color Doppler ultrasonography was first used in 1988 by Ralls et al. to evaluate blood flow to the thyroid gland in patients with Graves' disease [1]. The "thyroid inferno" is the imaging demonstration of markedly increased vascularity and arteriovenous shunting seen with Graves' Disease (Fig. 2 and…
Emerging Links Between PFAS Exposure and Autoimmune Thyroid Disease: A Narrative Review of Epidemiologic Evidence, Mechanistic Insights, and Research Gaps.
Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely distributed in the environment and human tissues. Known as endocrine-disrupting chemicals, PFAS are increasingly investigated for their potential role in the rising global prevalence of autoimmune thyroid diseases (…
A Diagnostic Pitfall: Acute Myeloid Leukemia Mimicking Methimazole-induced Agranulocytosis.
Methimazole is widely used for treating Graves' disease and it is a well-recognized cause of agranulocytosis. However, this assumption may delay the diagnosis of underlying hematologic disorders. A woman in her early 50s with Graves' disease had been treated with methimazole for 24 years. Routine la…
Graves' Disease Presenting as Refractory Panic Attacks: Diagnostic Clarification Through Thyroid Scintigraphy.
Graves' disease may rarely present with predominant neuropsychiatric symptoms, such as severe, treatment-resistant panic attacks, leading to misdiagnosis as a primary psychiatric disorder. We describe a 30-year-old woman with refractory panic attacks and night terrors who was initially treated with…
Teprotumumab-associated persistent unilateral hearing loss in dysthyroid optic neuropathy: a case report with review of the literature.
We report a case of severe thyroid eye disease (TED) complicated by dysthyroid optic neuropathy (DON) in a 55-year-old woman with Graves' disease. Despite insufficient response to high-dose intravenous steroid therapy, teprotumumab led to marked improvement in proptosis, orbital inflammation, and vi…
Passive Smoking and Thyroid Diseases: Association by Mendelian Randomization Study.
Existing literature has primarily focused on the associations between active smoking and thyroid diseases, while the causal mechanisms linking passive smoking to thyroid diseases remain insufficiently investigated. Therefore, we conducted a Mendelian randomization (MR) study to evaluate the potentia…