Causal association and shared mechanisms between Graves' disease and prostate cancer: insights from Mendelian randomization, machine learning, and comprehensive bioinformatics.
Observational studies link hyperthyroidism to increased prostate cancer (PCa) risk, but causality and mechanisms remain unclear. Graves' disease (GD), the primary cause of hyperthyroidism, involves chronic immune dysregulation that may influence PCa through shared immune pathways. We performed bidir…
Propylthiouracil (PTU), an antithyroid medication used in managing Graves disease, can rarely cause antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a potentially serious complication. We report a case of a 54-year-old woman with Graves disease on long-term PTU therapy who dev…
Vitamin D deficiency is common in Hashimoto's thyroiditis, while VDR FokI shows subtype-specific association with gravis disease in Jordan: a case-control study.
Vitamin D (VD) plays a crucial role in immune regulation via vitamin D receptor (VDR). VD deficiency and VDR gene polymorphism have been linked to autoimmune thyroid disease (AITD). This study investigated serum VD levels and four key VDR gene polymorphism (ApI, BsmI, FokI, TaqI) in the Jordanian po…
North American Society for Interventional Thyroidology (NASIT) Statement on the use of Embolization for the Management of Thyroid Disease.
To review the current evidence regarding thyroid artery embolization (TAE) for the management of benign and select malignant thyroid diseases and to present expert consensus recommendations from the North American Society for Interventional Thyroidology (NASIT) on patient selection, indications, tec…
Outcomes of radioactive iodine therapy with fixed-activity regimen in pediatric Graves' disease.
To evaluate the success rates of radioactive iodine therapy (RAIT) with fixed activity of 10mCi and 15mCi in pediatric patients with Graves' disease (GD). This retrospective study included patients aged ≤18 years diagnosed with GD who received 1st dose of RAIT by fixed activity regimen, eithe…
Incidence, Patterns and Predictors of Alemtuzumab-Induced Thyroid Dysfunction in Patients With Multiple Sclerosis: A Northern Ireland Cohort Study.
Alemtuzumab (Lemtrada) is highly effective for selected relapsing multiple sclerosis (MS) but can cause autoimmune thyroid dysfunction (AITD). Our aim was to retrospectively review patients and the monitoring of their thyroid function tests (TFTs) during and after treatment with alemtuzumab. We want…
Life-threatening fetal goiter: diagnosis and outcomes in four consecutive cases with critical appraisal-why this diagnosis is not obviously trivial.
The diagnosis of a fetal goiter constitutes a potentially life-threatening in utero condition for the fetus. Even with early diagnosis and close therapy with highly specialized interdisciplinary management, the prognosis remains poor. We discuss diagnostic and therapeutic challenges regarding the pr…
Predictive factors for remission in pediatric Graves' disease treated with antithyroid drugs: a retrospective study.
Pediatric Graves' disease (PGD) is a rare autoimmune disorder. Predictors of remission after antithyroid drug (ATD) therapy have been described, but their applicability in pediatric populations remains inconsistent. This study aimed to identify clinical and biochemical factors associated with remiss…