Thyroid function tests and resting heart rate in Graves` disease: a prospective longitudinal study.
Increased resting heart rate (RHR) is a typical sign of thyrotoxicosis. RHR may therefore serve as a monitoring tool, but longitudinal data on continuous measures of RHR and thyroid hormones are sparse. We evaluated the association between continuously monitored RHR and thyroid function tests in Gra…
Thyroid storm triggered by immune checkpoint inhibitor therapy.
While immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, they can cause immune-related adverse events, including thyroid dysfunction and rarely, thyroid storm. Here, we present a rare case of thyroid storm occurring during ICI therapy, in which clinical and immunological findi…
Cobblestoned ankles in Graves disease: koebnerized elephantiasic pretibial myxoedema.
A 61-year-old man with Graves disease presented with bilateral perimalleolar cobblestoned plaques, elephantiasic pretibial myxoedema, with a linear koebnerized tract. Biopsy confirmed thyroid dermopathy (compact orthokeratosis, acanthosis, abundant interstitial dermal mucin on Alcian blue-PAS). This…
The clinical significance of SIGLEC1 mRNA levels derived from peripheral leukocytes in autoimmune thyroid diseases and type 1 diabetes.
Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), may coexist with Type 1 diabetes mellitus (T1DM) as autoimmune polyglandular syndrome type 3 (APS3). Sialic acid-binding immunoglobulin-like lectin (SIGLEC) 1 is an interferon-inducible molecule impl…
Increased Risk of Venous Thromboembolism in Patients with Thyroid Eye Disease Compared to Graves' Disease Without Orbitopathy.
Autoimmune inflammatory disorders have been found to be associated with increased venous thromboembolism (VTE) risk. However, the association between Thyroid eye disease (TED) and systemic thrombotic events has not been characterized. This study evaluated whether TED is associated with increased VTE…
Time to euthyroidism and its predictors among thyrotoxicosis patients on antithyroid drugs at tertiary hospitals, Western Oromia, Ethiopia: a retrospective cohort study.
Thyrotoxicosis is characterized by excessive action of thyroid hormones in tissues, leading to significant morbidity and mortality. Anti-thyroid drugs are the primary treatment for thyrotoxicosis; however, the time required to achieve euthyroid status varies among patients. The aim of this study was…
American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum.
Thyroid disease in pregnancy, preconception, and postpartum is a common and clinically relevant problem. Since the publication of the American Thyroid Association (ATA) guidelines in 2017, substantial new clinical and scientific evidence has become available. The aim of these guidelines is to provid…