Psychotic depression associated with Graves' disease: A case report on treatment prioritization.
Graves' disease can be accompanied by psychiatric symptoms, including affective and psychotic manifestations. When a well-defined psychiatric syndrome occurs concurrently with a medical illness, determining whether it is directly attributable to the medical condition or represents an independent psy…
Causal association and shared mechanisms between Graves' disease and prostate cancer: insights from Mendelian randomization, machine learning, and comprehensive bioinformatics.
Observational studies link hyperthyroidism to increased prostate cancer (PCa) risk, but causality and mechanisms remain unclear. Graves' disease (GD), the primary cause of hyperthyroidism, involves chronic immune dysregulation that may influence PCa through shared immune pathways. We performed bidir…
Early vascular lesion tracking in moyamoya disease: A case report with serial findings.
Moyamoya disease (MMD) is characterized by progressive stenosis of the internal carotid arteries and the presence of abnormal collateral vessels. However, knowledge of the early stages of MMD is limited. This case report discusses a woman in her 30s who experienced unusual symptoms, such as hand dys…
Ectopic thyroid tissue in the breast mimicking a breast lesion: A rare case report.
Ectopic thyroid tissue is an uncommon developmental anomaly characterized by the presence of thyroid tissue outside its normal pre-tracheal site. This report describes a rare case of benign ectopic thyroid tissue in the breast of a 47-year-old woman after a history of Graves' disease and benign left…
Mitral valve regurgitation and emotional dysregulation secondary to long-standing Graves' thyrotoxicosis.
Graves' disease is common, with an estimated prevalence of 0.2-2% and multiple associated complications. We present a case of severe mitral regurgitation secondary to poorly controlled Graves' disease for 11 years, highlighting the need for definitive treatment. A 30-year-old female attended hospita…
Post Hoc MRI Analysis of Orbital Soft Tissue Volumes Pre- and Post-Teprotumumab in Patients with Chronic, Low-Activity Thyroid Eye Disease.
A previous phase 4 trial (Chronic) evaluated teprotumumab treatment in patients with chronic, low-activity thyroid eye disease (TED). In the current study, volumetric changes in the orbital soft tissues, lacrimal glands, and full facial fat were evaluated following teprotumumab in a subset of p…
Radioiodine or thyroidectomy in children and adolescents with Graves' disease: a structured literature review of efficacy and safety.
Graves' disease (GD) is the most common cause of hyperthyroidism in children and adolescents. When remission is not achieved with antithyroid drugs, definitive treatment with radioiodine therapy (RAI) or thyroidectomy is recommended. We conducted a structured literature review of studies indexed in…
Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.
Vitamin D, an important immunomodulator, has been implicated in the pathogenesis of thyroid disease. Although several studies have reported lower serum vitamin D levels in patients with autoimmune thyroid diseases (AITDS) and thyroid cancer, others have yielded shown inconsistent findings, leaving t…